Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation
Terry-Lorenzo, Ryan T, Chun, Lawrence E, Brown, Scott P, Heffernan, Michele L R, Fang, Q Kevin, Orsini, Michael A, Pollegioni, Loredano, Hardy, Larry W, Spear, Kerry L, Large, Thomas H
Published in Bioscience reports (11.08.2014)
Published in Bioscience reports (11.08.2014)
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Structural, Kinetic, and Pharmacodynamic Mechanisms of d‑Amino Acid Oxidase Inhibition by Small Molecules
Hopkins, Seth C, Heffernan, Michele L. R, Saraswat, Lakshmi D, Bowen, Carrie A, Melnick, Laurence, Hardy, Larry W, Orsini, Michael A, Allen, Michael S, Koch, Patrick, Spear, Kerry L, Foglesong, Robert J, Soukri, Mustapha, Chytil, Milan, Fang, Q. Kevin, Jones, Steven W, Varney, Mark A, Panatier, Aude, Oliet, Stephane H. R, Pollegioni, Loredano, Piubelli, Luciano, Molla, Gianluca, Nardini, Marco, Large, Thomas H
Published in Journal of medicinal chemistry (09.05.2013)
Published in Journal of medicinal chemistry (09.05.2013)
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Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain
Hopkins, Seth C, Zhao, Fei-Yue, Bowen, Carrie A, Fang, Xin, Wei, Haifeng, Heffernan, Michele L R, Spear, Kerry L, Spanswick, David C, Varney, Mark A, Large, Thomas H
Published in The Journal of pharmacology and experimental therapeutics (01.06.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2013)
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SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D2 Receptor Mechanism of Action
Dedic, Nina, Jones, Philip G, Hopkins, Seth C, Lew, Robert, Shao, Liming, Campbell, John E, Spear, Kerry L, Large, Thomas H, Campbell, Una C, Hanania, Taleen, Leahy, Emer, Koblan, Kenneth S
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
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Journal Article
SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D 2 Receptor Mechanism of Action
Dedic, Nina, Jones, Philip G, Hopkins, Seth C, Lew, Robert, Shao, Liming, Campbell, John E, Spear, Kerry L, Large, Thomas H, Campbell, Una C, Hanania, Taleen, Leahy, Emer, Koblan, Kenneth S
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
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Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors
Shao, Liming, Wang, Fengjiang, Malcolm, Scott C., Ma, Jianguo, Hewitt, Michael C., Campbell, Una C., Bush, Larry R., Spicer, Nancy A., Engel, Sharon R., Saraswat, Lakshmi D., Hardy, Larry W., Koch, Patrick, Schreiber, Rudy, Spear, Kerry L., Varney, Mark A.
Published in Bioorganic & medicinal chemistry (01.01.2011)
Published in Bioorganic & medicinal chemistry (01.01.2011)
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Effects of D‐amino acid oxidase inhibition on memory performance and long‐term potentiation in vivo
Hopkins, Seth C., Campbell, Una C., Heffernan, Michele L. R., Spear, Kerry L., Jeggo, Ross D., Spanswick, David C., Varney, Mark A., Large, Thomas H.
Published in Pharmacology research & perspectives (01.10.2013)
Published in Pharmacology research & perspectives (01.10.2013)
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Synthesis and Pharmacological Characterization of Bicyclic Triple Reuptake Inhibitor 3-Aryl Octahydrocyclopenta[c]pyrrole Analogues
Shao, Liming, Hewitt, Michael C, Malcolm, Scott C, Wang, Fengjiang, Ma, Jianguo, Campbell, Una C, Spicer, Nancy A, Engel, Sharon R, Hardy, Larry W, Jiang, Zhi-Dong, Schreiber, Rudy, Spear, Kerry L, Varney, Mark A
Published in Journal of medicinal chemistry (11.08.2011)
Published in Journal of medicinal chemistry (11.08.2011)
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Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor
Shao, Liming, Hewitt, Michael C., Wang, Fengjiang, Malcolm, Scott C., Ma, Jianguo, Campbell, John E., Campbell, Una C., Engel, Sharon R., Spicer, Nancy A., Hardy, Larry W., Schreiber, Rudy, Spear, Kerry L., Varney, Mark A.
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor
Shao, Liming, Ma, Jianguo, Wang, Fengjiang, Malcolm, Scott C., Hewitt, Michael C., Campbell, Una C., Spicer, Nancy A., Hardy, Larry W., Schreiber, Rudy, Spear, Kerry L., Varney, Mark A.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel
Gross, Michael F., Castle, Neil A., Zou, Anruo, Wickenden, Alan D., Yu, Weifeng, Spear, Kerry L.
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
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Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor
Shao, Liming, Hewitt, Michael C., Wang, Fengjiang, Malcolm, Scott C., Ma, Jianguo, Campbell, John E., Campbell, Una C., Engel, Sharon R., Spicer, Nancy A., Hardy, Larry W., Schreiber, Rudy, Spear, Kerry L., Varney, Mark A.
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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중추 신경계 장애를 치료하기 위한 1-헤테로사이클릴 이소크로만일 화합물 및 유사체
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Year of Publication 27.11.2017
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Year of Publication 27.11.2017
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DORSEY JAMES M, OGBU CYPRIAN O, SOUKRI MUSTAPHA, FANG QUN KEVIN, HOPKINS SETH C, SPEAR KERRY L, FOGLESONG ROBERT J, HEFFERNAN MICHELE L.R
Year of Publication 07.05.2010
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Year of Publication 07.05.2010
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