The open access malaria box: a drug discovery catalyst for neglected diseases
Spangenberg, Thomas, Burrows, Jeremy N, Kowalczyk, Paul, McDonald, Simon, Wells, Timothy N C, Willis, Paul
Published in PloS one (17.06.2013)
Published in PloS one (17.06.2013)
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Journal Article
Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model
Abla, Nada, Keiser, Jennifer, Vargas, Mireille, Reimers, Natalie, Haas, Helmut, Spangenberg, Thomas
Published in PLoS neglected tropical diseases (21.09.2017)
Published in PLoS neglected tropical diseases (21.09.2017)
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Journal Article
Repurposing of the Open Access Malaria Box for Kinetoplastid Diseases Identifies Novel Active Scaffolds against Trypanosomatids
Kaiser, Marcel, Maes, Louis, Tadoori, Leela Pavan, Spangenberg, Thomas, Ioset, Jean-Robert
Published in Journal of biomolecular screening (01.06.2015)
Published in Journal of biomolecular screening (01.06.2015)
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Journal Article
Genetic profiles of Schistosoma haematobium parasites from Malian transmission hotspot areas
Agniwo, Privat, Boissier, Jérôme, Sidibé, Bakary, Dembélé, Laurent, Diakité, Assitan, Niaré, Doumbo Safiatou, Akplogan, Ahristode, Guindo, Hassim, Blin, Manon, Dametto, Sarah, Ibikounlé, Moudachirou, Spangenberg, Thomas, Dabo, Abdoulaye
Published in Parasites & vectors (04.08.2023)
Published in Parasites & vectors (04.08.2023)
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Journal Article
Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice
Ajiboye, Jubilee, Teixeira, José E., Gasonoo, Makafui, Mattice, Ethan B., Korwin-Mihavics, Bethany, Miller, Peter, Cameron, Alexandra C., Stebbins, Erin, Campbell, Scott D., Griggs, David W., Spangenberg, Thomas, Meyers, Marvin J., Huston, Christopher D.
Published in Nature communications (27.09.2024)
Published in Nature communications (27.09.2024)
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Journal Article
Towards clinically relevant dose ratios for Cabamiquine and Pyronaridine combination using P. falciparum field isolate data
Maiga, Mohamed, Dembele, Laurent, Courlet, Perrine, Khandelwal, Akash, Dara, Antoine, Sogore, Fanta, Diakité, Ousmaila, Maiga, Fatoumata O., Dao, François, Sissoko, Sekou, Barre, Yacouba, Goita, Siaka, Diakite, Mahamadou, Diakite, Seidina A. S., Djimde, Abdoulaye A., Oeuvray, Claude, Spangenberg, Thomas, Wicha, Sebastian G., Demarta-Gatsi, Claudia
Published in Nature communications (03.09.2024)
Published in Nature communications (03.09.2024)
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Journal Article
Propensity of selecting mutant parasites for the antimalarial drug cabamiquine
Stadler, Eva, Maiga, Mohamed, Friedrich, Lukas, Thathy, Vandana, Demarta-Gatsi, Claudia, Dara, Antoine, Sogore, Fanta, Striepen, Josefine, Oeuvray, Claude, Djimdé, Abdoulaye A., Lee, Marcus C. S., Dembélé, Laurent, Fidock, David A., Khoury, David S., Spangenberg, Thomas
Published in Nature communications (25.08.2023)
Published in Nature communications (25.08.2023)
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Journal Article
Identification of Cryptosporidium parvum Active Chemical Series by Repurposing the Open Access Malaria Box
BESSOFF, Kovi, SPANGENBERG, Thomas, FODERARO, Jenna E, JUMANI, Rajiv S, WARD, Gary E, HUSTON, Christopher D
Published in Antimicrobial agents and chemotherapy (01.05.2014)
Published in Antimicrobial agents and chemotherapy (01.05.2014)
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Journal Article
Author Correction: Propensity of selecting mutant parasites for the antimalarial drug cabamiquine
Stadler, Eva, Maiga, Mohamed, Friedrich, Lukas, Thathy, Vandana, Demarta-Gatsi, Claudia, Dara, Antoine, Sogore, Fanta, Striepen, Josefine, Oeuvray, Claude, Djimdé, Abdoulaye A., Lee, Marcus C. S., Dembélé, Laurent, Fidock, David A., Khoury, David S., Spangenberg, Thomas
Published in Nature communications (06.09.2023)
Published in Nature communications (06.09.2023)
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Journal Article
Praziquantel Treatment of Schistosoma mansoni Infected Mice Renders Them Less Susceptible to Reinfection
Nono, Justin Komguep, Mpotje, Thabo, Mosala, Paballo, Aziz, Nada Abdel, Musaigwa, Fungai, Hlaka, Lerato, Spangenberg, Thomas, Brombacher, Frank
Published in Frontiers in immunology (10.12.2021)
Published in Frontiers in immunology (10.12.2021)
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Journal Article
Praziquantel Reduces Maternal Mortality and Offspring Morbidity by Enhancing Anti-Helminthic Immune Responses
Lacorcia, Matthew, Kugyelka, Réka, Spechtenhauser, Lorenz, Prodjinotho, Ulrich Fabien, Hamway, Youssef, Spangenberg, Thomas, da Costa, Clarissa Prazeres
Published in Frontiers in immunology (27.06.2022)
Published in Frontiers in immunology (27.06.2022)
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Journal Article
Publisher Correction: Genetic profiles of Schistosoma haematobium parasites from Malian transmission hotspot areas
Agniwo, Privat, Boissier, Jérôme, Sidibé, Bakary, Dembélé, Laurent, Diakité, Assitan, Niaré, Doumbo Safiatou, Akplogan, Ahristode, Guindo, Hassim, Blin, Manon, Dametto, Sarah, Ibikounlé, Moudachirou, Spangenberg, Thomas, Dabo, Abdoulaye
Published in Parasites & vectors (15.12.2023)
Published in Parasites & vectors (15.12.2023)
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Journal Article
Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside
Khandelwal, Akash, Arez, Francisca, Alves, Paula M., Badolo, Lassina, Brito, Catarina, Fischli, Christoph, Fontinha, Diana, Oeuvray, Claude, Prudêncio, Miguel, Rottmann, Matthias, Wilkins, Justin, Yalkinoglu, Özkan, Bagchus, Wilhelmina M., Spangenberg, Thomas
Published in Malaria journal (15.05.2022)
Published in Malaria journal (15.05.2022)
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Journal Article
Short Access to (+)-Lupinine and (+)-Epiquinamide via Double Hydroformylation
Airiau, Etienne, Spangenberg, Thomas, Girard, Nicolas, Breit, Bernhard, Mann, André
Published in Organic letters (05.02.2010)
Published in Organic letters (05.02.2010)
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Journal Article
Orally active antischistosomal early leads identified from the open access malaria box
Ingram-Sieber, Katrin, Cowan, Noemi, Panic, Gordana, Vargas, Mireille, Mansour, Nuha R, Bickle, Quentin D, Wells, Timothy N C, Spangenberg, Thomas, Keiser, Jennifer
Published in PLoS neglected tropical diseases (01.01.2014)
Published in PLoS neglected tropical diseases (01.01.2014)
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Journal Article
Identification of hit compounds with anti-schistosomal activity on in vitro generated juvenile worms in cell-free medium
Vejzagic, Nermina, Prodjinotho, Ulrich Fabien, El-Khafif, Nagwa, Huang, Ruili, Simeonov, Anton, Spangenberg, Thomas, Prazeres da Costa, Clarissa
Published in PLoS neglected tropical diseases (25.05.2021)
Published in PLoS neglected tropical diseases (25.05.2021)
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Journal Article
A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments
Huston, Christopher D, Spangenberg, Thomas, Burrows, Jeremy, Willis, Paul, Wells, Timothy N C, van Voorhis, Wesley
Published in PLoS neglected tropical diseases (01.10.2015)
Published in PLoS neglected tropical diseases (01.10.2015)
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Journal Article
Repurposing the open access malaria box to discover potent inhibitors of Toxoplasma gondii and Entamoeba histolytica
Boyom, Fabrice F, Fokou, Patrick V T, Tchokouaha, Lauve R Y, Spangenberg, Thomas, Mfopa, Alvine N, Kouipou, Ruffin M T, Mbouna, Cedric J, Donfack, Valerie F Donkeng, Zollo, Paul H A
Published in Antimicrobial agents and chemotherapy (01.10.2014)
Published in Antimicrobial agents and chemotherapy (01.10.2014)
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Journal Article
Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum
Avery, Vicky M, Bashyam, Sridevi, Burrows, Jeremy N, Duffy, Sandra, Papadatos, George, Puthukkuti, Shyni, Sambandan, Yuvaraj, Singh, Shivendra, Spangenberg, Thomas, Waterson, David, Willis, Paul
Published in Malaria journal (27.05.2014)
Published in Malaria journal (27.05.2014)
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Journal Article