Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor
He, Wei, Myers, Michael R., Hanney, Barbara, Spada, Alfred P., Bilder, Glenda, Galzcinski, Helen, Amin, Dilip, Needle, Saul, Page, Ken, Jayyosi, Zaid, Perrone, Mark H.
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Published in Bioorganic & medicinal chemistry letters (15.09.2003)
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Emricasan (IDN‐6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension
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Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-Stage Liver Disease Scores Compared With Placebo
Frenette, Catherine T., Morelli, Giuseppe, Shiffman, Mitchell L., Frederick, R. Todd, Rubin, Raymond A., Fallon, Michael B., Cheng, Jason T., Cave, Matt, Khaderi, Saira A., Massoud, Omar, Pyrsopoulos, Nikolaos, Park, James S., Robinson, James M., Yamashita, Mason, Spada, Alfred P., Chan, Jean L., Hagerty, David T.
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Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo
Kopec, Anna K, Spada, Alfred P, Contreras, Patricia C, Mackman, Nigel, Luyendyk, James P
Published in Toxicological sciences (01.04.2018)
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Structural and Functional Analysis of Caspase Active Sites
Chéreau, David, Kodandapani, Lalitha, Tomaselli, Kevin J, Spada, Alfred P, Wu, Joe C
Published in Biochemistry (Easton) (15.04.2003)
Published in Biochemistry (Easton) (15.04.2003)
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Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR Exploration and Effective Bioisosteric Replacement of a phenyl substituent
Myers, Michael R., He, Wei, Hanney, Barbara, Setzer, Natalie, Maguire, Martin P., Zulli, Allison, Bilder, Glenda, Galzcinski, Helen, Amin, Dilip, Needle, Saul, Spada, Alfred P.
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
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Molecular Structures of Human Factor Xa Complexed with Ketopiperazine Inhibitors: Preference for a Neutral Group in the S1 Pocket
Maignan, Sébastien, Guilloteau, Jean-Pierre, Choi-Sledeski, Yong Mi, Becker, Michael R, Ewing, William R, Pauls, Henry W, Spada, Alfred P, Mikol, Vincent
Published in Journal of medicinal chemistry (27.02.2003)
Published in Journal of medicinal chemistry (27.02.2003)
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In Vitro Characterization of a Novel Factor Xa Inhibitor, RPR 130737
Chu, Valeria, Brown, Karen, Colussi, Dennis, Choi, Yong-Mi, Green, Dan, Pauls, Henry W, Spada, Alfred P, Perrone, Mark H, Leadley, Robert J, Dunwiddie, Christopher T
Published in Thrombosis research (01.07.2000)
Published in Thrombosis research (01.07.2000)
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Crystal Structures of Human Factor Xa Complexed with Potent Inhibitors
Maignan, Sébastien, Guilloteau, Jean-Pierre, Pouzieux, Stéphanie, Choi-Sledeski, Yong Mi, Becker, Michael R, Klein, Scott I, Ewing, William R, Pauls, Henry W, Spada, Alfred P, Mikol, Vincent
Published in Journal of medicinal chemistry (24.08.2000)
Published in Journal of medicinal chemistry (24.08.2000)
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Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity
Guertin, Kevin R, Gardner, Charles J, Klein, Scott I, Zulli, Allison L, Czekaj, Mark, Gong, Yong, Spada, Alfred P, Cheney, Daniel L, Maignan, Sebastian, Guilloteau, Jean-Pierre, Brown, Karen D, Colussi, Dennis J, Chu, Valeria, Heran, Christopher L, Morgan, Suzanne R, Bentley, Ross G, Dunwiddie, Christopher T, Leadley, Robert J, Pauls, Henry W
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
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Conformational restrictions in the active site of unliganded human caspase-3
Ni, Chao-Zhou, Li, Chenglong, Wu, Joe C., Spada, Alfred P., Ely, Kathryn R.
Published in Journal of molecular recognition (01.05.2003)
Published in Journal of molecular recognition (01.05.2003)
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A Nucleotide Binding Site in Caspase-9 Regulates Apoptosome Activation
Chereau, David, Zou, Hua, Spada, Alfred P, Wu, Joe C
Published in Biochemistry (Easton) (05.04.2005)
Published in Biochemistry (Easton) (05.04.2005)
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Optimization of the β-aminoester class of factor Xa inhibitors. Part 1: P4 and side-chain modifications for improved in vitro potency
CZEKAJ, Mark, KLEIN, Scott I, CHU, Valeria, LEADLEY, Robert J, DUNWIDDIE, Christopher T, GUERTIN, Kevin R, GARDNER, Charles J, ZULLI, Allison L, PAULS, Henry W, SPADA, Alfred P, CHENEY, Daniel L, BROWN, Karen D, COLUSSI, Dennis J
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
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The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice
YONEDA, T, LYALL, R. M, ALSINA, M. M, PERSONS, P. E, SPADA, A. P, LEVITZKI, A, ZILBERSTEIN, A, MUNDY, G. R
Published in Cancer research (Chicago, Ill.) (15.08.1991)
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Published in Cancer research (Chicago, Ill.) (15.08.1991)
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Identification and Initial Structure−Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor Xa
Klein, Scott I, Czekaj, Mark, Gardner, Charles J, Guertin, Kevin R, Cheney, Daniel L, Spada, Alfred P, Bolton, Scott A, Brown, Karen, Colussi, Dennis, Heran, Christopher L, Morgan, Suzanne R, Leadley, Robert J, Dunwiddie, Christopher T, Perrone, Mark H, Chu, Valeria
Published in Journal of medicinal chemistry (12.02.1998)
Published in Journal of medicinal chemistry (12.02.1998)
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Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors
WEI HE, HANNEY, Barbara, MYERS, Michael R, CONDON, Stephen, BECKER, Michael R, SPADA, Alfred P, BURNS, Christopher, BROWN, Karen, COLUSSI, Dennis, CHU, Valeria
Published in Bioorganic & medicinal chemistry letters (25.03.2002)
Published in Bioorganic & medicinal chemistry letters (25.03.2002)
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