Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation
Wang, Wuyang, Gao, Qiong, Yang, Meimei, Zhang, Xiaoli, Yu, Lu, Lawas, Maria, Li, Xinran, Bryant-Genevier, Marthe, Southall, Noel T., Marugan, Juan, Ferrer, Marc, Xu, Haoxing
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2015)
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High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer
Datta, Amrita, Kim, Hogyoung, McGee, Lauren, Johnson, Adedoyin E., Talwar, Sudha, Marugan, Juan, Southall, Noel, Hu, Xin, Lal, Madhu, Mondal, Debasis, Ferrer, Marc, Abdel-Mageed, Asim B.
Published in Scientific reports (25.05.2018)
Published in Scientific reports (25.05.2018)
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The NCATS BioPlanet - An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics
Huang, Ruili, Grishagin, Ivan, Wang, Yuhong, Zhao, Tongan, Greene, Jon, Obenauer, John C, Ngan, Deborah, Nguyen, Dac-Trung, Guha, Rajarshi, Jadhav, Ajit, Southall, Noel, Simeonov, Anton, Austin, Christopher P
Published in Frontiers in pharmacology (26.04.2019)
Published in Frontiers in pharmacology (26.04.2019)
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Journal Article
Critical Assessment of Artificial Intelligence Methods for Prediction of hERG Channel Inhibition in the “Big Data” Era
Siramshetty, Vishal B, Nguyen, Dac-Trung, Martinez, Natalia J, Southall, Noel T, Simeonov, Anton, Zakharov, Alexey V
Published in Journal of chemical information and modeling (28.12.2020)
Published in Journal of chemical information and modeling (28.12.2020)
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Journal Article
Pharos: Collating protein information to shed light on the druggable genome
Nguyen, Dac-Trung, Mathias, Stephen, Bologa, Cristian, Brunak, Soren, Fernandez, Nicolas, Gaulton, Anna, Hersey, Anne, Holmes, Jayme, Jensen, Lars Juhl, Karlsson, Anneli, Liu, Guixia, Ma'ayan, Avi, Mandava, Geetha, Mani, Subramani, Mehta, Saurabh, Overington, John, Patel, Juhee, Rouillard, Andrew D, Schürer, Stephan, Sheils, Timothy, Simeonov, Anton, Sklar, Larry A, Southall, Noel, Ursu, Oleg, Vidovic, Dusica, Waller, Anna, Yang, Jeremy, Jadhav, Ajit, Oprea, Tudor I, Guha, Rajarshi
Published in Nucleic acids research (04.01.2017)
Published in Nucleic acids research (04.01.2017)
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Journal Article
Clinical development times for innovative drugs
Brown, Dean G., Wobst, Heike J., Kapoor, Abhijeet, Kenna, Leslie A., Southall, Noel
Published in Nature reviews. Drug discovery (01.11.2022)
Published in Nature reviews. Drug discovery (01.11.2022)
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Journal Article
The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics
Huang, Ruili, Southall, Noel, Wang, Yuhong, Yasgar, Adam, Shinn, Paul, Jadhav, Ajit, Nguyen, Dac-Trung, Austin, Christopher P
Published in Science translational medicine (27.04.2011)
Published in Science translational medicine (27.04.2011)
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Journal Article
NCATS Inxight Drugs: a comprehensive and curated portal for translational research
Siramshetty, Vishal B, Grishagin, Ivan, Nguyễn, Ðắc-Trung, Peryea, Tyler, Skovpen, Yulia, Stroganov, Oleg, Katzel, Daniel, Sheils, Timothy, Jadhav, Ajit, Mathé, Ewy A, Southall, Noel T
Published in Nucleic acids research (07.01.2022)
Published in Nucleic acids research (07.01.2022)
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Journal Article
COPI complex is a regulator of lipid homeostasis
Beller, Mathias, Sztalryd, Carole, Southall, Noel, Bell, Ming, Jäckle, Herbert, Auld, Douglas S, Oliver, Brian
Published in PLoS biology (01.11.2008)
Published in PLoS biology (01.11.2008)
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Journal Article
Evaluating kratom alkaloids using PHASE
Ellis, Christopher R, Racz, Rebecca, Kruhlak, Naomi L, Kim, Marlene T, Zakharov, Alexey V, Southall, Noel, Hawkins, Edward G, Burkhart, Keith, Strauss, David G, Stavitskaya, Lidiya
Published in PloS one (03.03.2020)
Published in PloS one (03.03.2020)
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Journal Article
A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis
Samie, Mohammad, Wang, Xiang, Zhang, Xiaoli, Goschka, Andrew, Li, Xinran, Cheng, Xiping, Gregg, Evan, Azar, Marlene, Zhuo, Yue, Garrity, Abigail G., Gao, Qiong, Slaugenhaupt, Susan, Pickel, Jim, Zolov, Sergey N., Weisman, Lois S., Lenk, Guy M., Titus, Steve, Bryant-Genevier, Marthe, Southall, Noel, Juan, Marugan, Ferrer, Marc, Xu, Haoxing
Published in Developmental cell (16.09.2013)
Published in Developmental cell (16.09.2013)
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Journal Article
The use or generation of biomedical data and existing medicines to discover and establish new treatments for patients with rare diseases - recommendations of the IRDiRC Data Mining and Repurposing Task Force
Southall, Noel T, Natarajan, Madhusudan, Lau, Lilian Pek Lian, Jonker, Anneliene Hechtelt, Deprez, Benoît, Guilliams, Tim, Hunter, Lawrence, Rademaker, Carin Ma, Hivert, Virginie, Ardigò, Diego
Published in Orphanet journal of rare diseases (15.10.2019)
Published in Orphanet journal of rare diseases (15.10.2019)
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Journal Article
A patient safety knowledge graph supporting vaccine product development
Simms, Andrew M, Kanakia, Anshul, Sipra, Muhammad, Dutta, Bhaskar, Southall, Noel
Published in BMC medical informatics and decision making (04.01.2024)
Published in BMC medical informatics and decision making (04.01.2024)
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Journal Article
Fluorescence Spectroscopic Profiling of Compound Libraries
Simeonov, Anton, Jadhav, Ajit, Thomas, Craig J, Wang, Yuhong, Huang, Ruili, Southall, Noel T, Shinn, Paul, Smith, Jeremy, Austin, Christopher P, Auld, Douglas S, Inglese, James
Published in Journal of medicinal chemistry (24.04.2008)
Published in Journal of medicinal chemistry (24.04.2008)
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Journal Article
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection
He, Shanshan, Lin, Billy, Chu, Virginia, Hu, Zongyi, Hu, Xin, Xiao, Jingbo, Wang, Amy Q, Schweitzer, Cameron J, Li, Qisheng, Imamura, Michio, Hiraga, Nobuhiko, Southall, Noel, Ferrer, Marc, Zheng, Wei, Chayama, Kazuaki, Marugan, Juan J, Liang, T Jake
Published in Science translational medicine (08.04.2015)
Published in Science translational medicine (08.04.2015)
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Journal Article
How Ions Affect the Structure of Water
Hribar, Barbara, Southall, Noel T, Vlachy, Vojko, Dill, Ken A
Published in Journal of the American Chemical Society (16.10.2002)
Published in Journal of the American Chemical Society (16.10.2002)
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Journal Article
Macrophage models of Gaucher disease for evaluating disease pathogenesis and candidate drugs
Aflaki, Elma, Stubblefield, Barbara K, Maniwang, Emerson, Lopez, Grisel, Moaven, Nima, Goldin, Ehud, Marugan, Juan, Patnaik, Samarjit, Dutra, Amalia, Southall, Noel, Zheng, Wei, Tayebi, Nahid, Sidransky, Ellen
Published in Science translational medicine (11.06.2014)
Published in Science translational medicine (11.06.2014)
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Journal Article
Characterization of Chemical Libraries for Luciferase Inhibitory Activity
Auld, Douglas S, Southall, Noel T, Jadhav, Ajit, Johnson, Ronald L, Diller, David J, Simeonov, Anton, Austin, Christopher P, Inglese, James
Published in Journal of medicinal chemistry (24.04.2008)
Published in Journal of medicinal chemistry (24.04.2008)
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Journal Article
Discovery, Structure–Activity Relationship, and Biological Evaluation of Noninhibitory Small Molecule Chaperones of Glucocerebrosidase
Patnaik, Samarjit, Zheng, Wei, Choi, Jae H, Motabar, Omid, Southall, Noel, Westbroek, Wendy, Lea, Wendy A, Velayati, Arash, Goldin, Ehud, Sidransky, Ellen, Leister, William, Marugan, Juan J
Published in Journal of medicinal chemistry (28.06.2012)
Published in Journal of medicinal chemistry (28.06.2012)
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