From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors
Ashkenazi, Avi, Fairbrother, Wayne J., Leverson, Joel D., Souers, Andrew J.
Published in Nature reviews. Drug discovery (01.04.2017)
Published in Nature reviews. Drug discovery (01.04.2017)
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Journal Article
Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models
Punnoose, Elizabeth A, Leverson, Joel D, Peale, Franklin, Boghaert, Erwin R, Belmont, Lisa D, Tan, Nguyen, Young, Amy, Mitten, Michael, Ingalla, Ellen, Darbonne, Walter C, Oleksijew, Anatol, Tapang, Paul, Yue, Peng, Oeh, Jason, Lee, Leslie, Maiga, Sophie, Fairbrother, Wayne J, Amiot, Martine, Souers, Andrew J, Sampath, Deepak
Published in Molecular cancer therapeutics (01.05.2016)
Published in Molecular cancer therapeutics (01.05.2016)
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Journal Article
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Souers, Andrew J, Leverson, Joel D, Boghaert, Erwin R, Ackler, Scott L, Catron, Nathaniel D, Chen, Jun, Dayton, Brian D, Ding, Hong, Enschede, Sari H, Fairbrother, Wayne J, Huang, David C S, Hymowitz, Sarah G, Jin, Sha, Khaw, Seong Lin, Kovar, Peter J, Lam, Lloyd T, Lee, Jackie, Maecker, Heather L, Marsh, Kennan C, Mason, Kylie D, Mitten, Michael J, Nimmer, Paul M, Oleksijew, Anatol, Park, Chang H, Park, Cheol-Min, Phillips, Darren C, Roberts, Andrew W, Sampath, Deepak, Seymour, John F, Smith, Morey L, Sullivan, Gerard M, Tahir, Stephen K, Tse, Chris, Wendt, Michael D, Xiao, Yu, Xue, John C, Zhang, Haichao, Humerickhouse, Rod A, Rosenberg, Saul H, Elmore, Steven W
Published in Nature medicine (01.02.2013)
Published in Nature medicine (01.02.2013)
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Journal Article
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
Leverson, Joel D, Phillips, Darren C, Mitten, Michael J, Boghaert, Erwin R, Diaz, Dolores, Tahir, Stephen K, Belmont, Lisa D, Nimmer, Paul, Xiao, Yu, Ma, Xiaoju Max, Lowes, Kym N, Kovar, Peter, Chen, Jun, Jin, Sha, Smith, Morey, Xue, John, Zhang, Haichao, Oleksijew, Anatol, Magoc, Terrance J, Vaidya, Kedar S, Albert, Daniel H, Tarrant, Jacqueline M, La, Nghi, Wang, Le, Tao, Zhi-Fu, Wendt, Michael D, Sampath, Deepak, Rosenberg, Saul H, Tse, Chris, Huang, David C S, Fairbrother, Wayne J, Elmore, Steven W, Souers, Andrew J
Published in Science translational medicine (18.03.2015)
Published in Science translational medicine (18.03.2015)
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Journal Article
Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐XL–BAX interaction
Saleh, Tareq, Carpenter, Valerie J., Tyutyunyk‐Massey, Liliya, Murray, Graeme, Leverson, Joel D., Souers, Andrew J., Alotaibi, Moureq R., Faber, Anthony C., Reed, Jason, Harada, Hisashi, Gewirtz, David A.
Published in Molecular oncology (01.10.2020)
Published in Molecular oncology (01.10.2020)
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Journal Article
MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor
Xiao, Yu, Nimmer, Paul, Sheppard, George S, Bruncko, Milan, Hessler, Paul, Lu, Xin, Roberts-Rapp, Lisa, Pappano, William N, Elmore, Steven W, Souers, Andrew J, Leverson, Joel D, Phillips, Darren C
Published in Molecular cancer therapeutics (01.08.2015)
Published in Molecular cancer therapeutics (01.08.2015)
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Journal Article
Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma
Lochmann, Timothy L, Powell, Krista M, Ham, Jungoh, Floros, Konstantinos V, Heisey, Daniel A R, Kurupi, Richard I J, Calbert, Marissa L, Ghotra, Maninderjit S, Greninger, Patricia, Dozmorov, Mikhail, Gowda, Madhu, Souers, Andrew J, Reynolds, C Patrick, Benes, Cyril H, Faber, Anthony C
Published in Science translational medicine (16.05.2018)
Published in Science translational medicine (16.05.2018)
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Journal Article
Increased Synthesis of MCL-1 Protein Underlies Initial Survival of EGFR -Mutant Lung Cancer to EGFR Inhibitors and Provides a Novel Drug Target
Song, Kyung-A, Hosono, Yasuyuki, Turner, Crystal, Jacob, Sheeba, Lochmann, Timothy L, Murakami, Yoshiko, Patel, Neha U, Ham, Jungoh, Hu, Bin, Powell, Krista M, Coon, Colin M, Windle, Brad E, Oya, Yuko, Koblinski, Jennifer E, Harada, Hisashi, Leverson, Joel D, Souers, Andrew J, Hata, Aaron N, Boikos, Sosipatros, Yatabe, Yasushi, Ebi, Hiromichi, Faber, Anthony C
Published in Clinical cancer research (15.11.2018)
Published in Clinical cancer research (15.11.2018)
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Journal Article
Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein
Petros, Andrew M., Swann, Steven L., Song, Danying, Swinger, Kerren, Park, Chang, Zhang, Haichao, Wendt, Michael D., Kunzer, Aaron R., Souers, Andrew J., Sun, Chaohong
Published in Bioorganic & medicinal chemistry letters (15.03.2014)
Published in Bioorganic & medicinal chemistry letters (15.03.2014)
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Journal Article
MCL1 nuclear translocation induces chemoresistance in colorectal carcinoma
Fu, Dechen, Pfannenstiel, Luke, Demelash, Abeba, Phoon, Yee Peng, Mayell, Cameron, Cabrera, Claudia, Liu, Caini, Zhao, Junjie, Dermawan, Josephine, Patil, Deepa, DeVecchio, Jennifer, Kalady, Matthew, Souers, Andrew J., Phillips, Darren C., Li, Xiaoxia, Gastman, Brian
Published in Cell death & disease (18.01.2022)
Published in Cell death & disease (18.01.2022)
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Journal Article
Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients
Yuda, Junichiro, Will, Christine, Phillips, Darren C., Abraham, Linu, Alvey, Cory, Avigdor, Abraham, Buck, Wayne, Besenhofer, Lauren, Boghaert, Erwin, Cheng, Dong, Cojocari, Dan, Doyle, Kelly, Hansen, T. Matthew, Huang, Kevin, Johnson, Eric F., Judd, Andrew S., Judge, Russell A., Kalvass, John C., Kunzer, Aaron, Lam, Lloyd T., Li, Rachel, Martin, Ruth L., Mastracchio, Anthony, Mitten, Mike, Petrich, Adam, Wang, Jin, Ward, James E., Zhang, Haichao, Wang, Xilu, Wolff, Johannes E., Bell-McGuinn, Katherine M., Souers, Andrew J.
Published in Communications medicine (25.10.2023)
Published in Communications medicine (25.10.2023)
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Journal Article
Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA
Fairchild, Carter K., Floros, Konstantinos V., Jacob, Sheeba, Coon, Colin M., Puchalapalli, Madhavi, Hu, Bin, Harada, Hisashi, Dozmorov, Mikhail G., Koblinski, Jennifer E., Smith, Steven C., Domson, Gregory, Leverson, Joel D., Souers, Andrew J., Takebe, Naoko, Ebi, Hiromichi, Faber, Anthony C., Boikos, Sosipatros A.
Published in Cancers (12.05.2021)
Published in Cancers (12.05.2021)
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Journal Article
Diacylglycerol Acyltransferase 1 Inhibition Lowers Serum Triglycerides in the Zucker Fatty Rat and the Hyperlipidemic Hamster
King, Andrew J, Segreti, Jason A, Larson, Kelly J, Souers, Andrew J, Kym, Philip R, Reilly, Regina M, Zhao, Gang, Mittelstadt, Scott W, Cox, Bryan F
Published in The Journal of pharmacology and experimental therapeutics (01.08.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2009)
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Journal Article
Identification and Preliminary Characterization of a Potent, Safe, and Orally Efficacious Inhibitor of Acyl-CoA:Diacylglycerol Acyltransferase 1
Yeh, Vince S. C, Beno, David W. A, Brodjian, Sevan, Brune, Michael E, Cullen, Steven C, Dayton, Brian D, Dhaon, Madhup K, Falls, Hugh D, Gao, Ju, Grihalde, Nelson, Hajduk, Philip, Hansen, T. Matthew, Judd, Andrew S, King, Andrew J, Klix, Russel C, Larson, Kelly J, Lau, Yau Y, Marsh, Kennan C, Mittelstadt, Scott W, Plata, Dan, Rozema, Michael J, Segreti, Jason A, Stoner, Eric J, Voorbach, Martin J, Wang, Xiaojun, Xin, Xili, Zhao, Gang, Collins, Christine A, Cox, Bryan F, Reilly, Regina M, Kym, Philip R, Souers, Andrew J
Published in Journal of medicinal chemistry (23.02.2012)
Published in Journal of medicinal chemistry (23.02.2012)
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Journal Article
The Use of Three-Dimensional Shape and Electrostatic Similarity Searching in the Identification of a Melanin-Concentrating Hormone Receptor 1 Antagonist
Muchmore, Steven W., Souers, Andrew J., Akritopoulou-Zanze, Irini
Published in Chemical biology & drug design (01.02.2006)
Published in Chemical biology & drug design (01.02.2006)
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Journal Article
Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax
Leverson, Joel D, Sampath, Deepak, Souers, Andrew J, Rosenberg, Saul H, Fairbrother, Wayne J, Amiot, Martine, Konopleva, Marina, Letai, Anthony
Published in Cancer discovery (01.12.2017)
Published in Cancer discovery (01.12.2017)
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Journal Article
Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X L -BAX interaction
Saleh, Tareq, Carpenter, Valerie J, Tyutyunyk-Massey, Liliya, Murray, Graeme, Leverson, Joel D, Souers, Andrew J, Alotaibi, Moureq R, Faber, Anthony C, Reed, Jason, Harada, Hisashi, Gewirtz, David A
Published in Molecular oncology (01.10.2020)
Published in Molecular oncology (01.10.2020)
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Journal Article
New era for myelofibrosis treatment with novel agents beyond Janus kinase‐inhibitor monotherapy: Focus on clinical development of BCL‐XL/BCL‐2 inhibition with navitoclax
Pemmaraju, Naveen, Garcia, Jacqueline S, Perkins, Andrew, Harb, Jason G, Souers, Andrew J, Werner, Michael E, Brown, Christopher M, Passamonti, Francesco
Published in Cancer (15.11.2023)
Published in Cancer (15.11.2023)
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