Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression
Lochmann, Timothy L, Floros, Konstantinos V, Naseri, Mitra, Powell, Krista M, Cook, Wade, March, Ryan J, Stein, Giovanna T, Greninger, Patricia, Maves, Yuki Kato, Saunders, Laura R, Dylla, Scott J, Costa, Carlotta, Boikos, Sosipatros A, Leverson, Joel D, Souers, Andrew J, Krystal, Geoffrey W, Harada, Hisashi, Benes, Cyril H, Faber, Anthony C
Published in Clinical cancer research (15.01.2018)
Published in Clinical cancer research (15.01.2018)
Get full text
Journal Article
Senolytic-Mediated Elimination of Head and Neck Tumor Cells Induced Into Senescence by Cisplatin
Ahmadinejad, Fereshteh, Bos, Tasia, Hu, Bin, Britt, Erin, Koblinski, Jennifer, Souers, Andrew J, Leverson, Joel D, Faber, Anthony C, Gewirtz, David A, Harada, Hisashi
Published in Molecular pharmacology (01.03.2022)
Published in Molecular pharmacology (01.03.2022)
Get full text
Journal Article
Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
Li, Wei, Sano, Renata, Apatira, Mutiah, DeAnda, Felix, Gururaja, Tarikere, Yang, Muhua, Lundgaard, Greta, Pan, Chin, Liu, Jing, Zhai, Yongjiao, Yoon, Woo Hyun, Wang, Longcheng, Tse, Chris, Souers, Andrew J, Lee, Chih-Hung
Published in Molecular cancer therapeutics (03.01.2024)
Published in Molecular cancer therapeutics (03.01.2024)
Get full text
Journal Article
A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies
Phillips, Darren C., Jin, Sha, Gregory, Gareth P., Zhang, Qi, Xue, John, Zhao, Xiaoxian, Chen, Jun, Tong, Yunsong, Zhang, Haichao, Smith, Morey, Tahir, Stephen K., Clark, Rick F., Penning, Thomas D., Devlin, Jennifer R., Shortt, Jake, Hsi, Eric D., Albert, Daniel H., Konopleva, Marina, Johnstone, Ricky W., Leverson, Joel D., Souers, Andrew J.
Published in Leukemia (01.06.2020)
Published in Leukemia (01.06.2020)
Get full text
Journal Article
Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity
Bruncko, Milan, Wang, Le, Sheppard, George S, Phillips, Darren C, Tahir, Stephen K, Xue, John, Erickson, Scott, Fidanze, Steve, Fry, Elizabeth, Hasvold, Lisa, Jenkins, Gary J, Jin, Sha, Judge, Russell A, Kovar, Peter J, Madar, David, Nimmer, Paul, Park, Chang, Petros, Andrew M, Rosenberg, Saul H, Smith, Morey L, Song, Xiaohong, Sun, Chaohong, Tao, Zhi-Fu, Wang, Xilu, Xiao, Yu, Zhang, Haichao, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J
Published in Journal of medicinal chemistry (12.03.2015)
Published in Journal of medicinal chemistry (12.03.2015)
Get full text
Journal Article
Discovery and Characterization of Aminopiperidinecoumarin Melanin Concentrating Hormone Receptor 1 Antagonists
Kym, Philip R, Iyengar, Rajesh, Souers, Andrew J, Lynch, John K, Judd, Andrew S, Gao, Ju, Freeman, Jennifer, Mulhern, Mathew, Zhao, Gang, Vasudevan, Anil, Wodka, Dariusz, Blackburn, Christopher, Brown, Jim, Che, Jennifer Lee, Cullis, Courtney, Lai, Su Jen, LaMarche, Matthew J, Marsilje, Tom, Roses, Jon, Sells, Todd, Geddes, Brad, Govek, Elizabeth, Patane, Michael, Fry, Dennis, Dayton, Brian D, Brodjian, Sevan, Falls, Doug, Brune, Michael, Bush, Eugene, Shapiro, Robin, Knourek-Segel, Victoria, Fey, Thomas, McDowell, Cathleen, Reinhart, Glenn A, Preusser, Lee C, Marsh, Kennan, Hernandez, Lisa, Sham, Hing L, Collins, Christine A
Published in Journal of medicinal chemistry (22.09.2005)
Published in Journal of medicinal chemistry (22.09.2005)
Get full text
Journal Article
Pharmaceutical Development Challenges in a Beyond Rule of Five Prodrug: Case Study of ABBV-167, Phosphate Prodrug of Venetoclax
Hong, Richard, Nie, Haichen, Henry, Rodger F., Garner, Sean M., Catron, Nathaniel D., Hertzler, Russell L., Souers, Andrew J., Sheikh, Ahmad Y., Chen, Shuang
Published in Molecular pharmaceutics (06.11.2023)
Published in Molecular pharmaceutics (06.11.2023)
Get full text
Journal Article
Acquired resistance to venetoclax (ABT-199) in t(14;18) positive lymphoma cells
Bodo, Juraj, Zhao, Xiaoxian, Durkin, Lisa, Souers, Andrew J, Phillips, Darren C, Smith, Mitchell R, Hsi, Eric D
Published in Oncotarget (25.10.2016)
Published in Oncotarget (25.10.2016)
Get full text
Journal Article
A cascade reaction sequence en route to 7-substituted 2-aminopyrrolo[1,2- a]pyrimidine-4,6-diones and the corresponding acrylic acid derivatives
Gao, Ju, Henry, Rodger F., Pagano, Thomas G., Duerst, Richard W., Souers, Andrew J.
Published in Tetrahedron letters (01.10.2007)
Published in Tetrahedron letters (01.10.2007)
Get full text
Journal Article
Enabling, Decagram-Scale Synthesis of Macrocyclic MCL‑1 Inhibitor ABBV-467
Brady, Patrick B., Sorensen, Bryan K., Risi, Roberto M., Curtin, Michael L., Mantei, Robert A., Florjancic, Alan S., Mastracchio, Anthony, Ji, Cheng, Kunzer, Aaron R., Lai, Chunqiu, Storer, Gregory E., Chan, Vincent S., Henry, Rodger F., Souers, Andrew J., Michaelides, Michael R., Judd, Andrew S., Hansen, T. Matthew
Published in Journal of organic chemistry (17.11.2023)
Published in Journal of organic chemistry (17.11.2023)
Get full text
Journal Article
Identification of recurrent genomic alterations in the apoptotic machinery in chronic lymphocytic leukemia patients treated with venetoclax monotherapy
Popovic, Relja, Dunbar, Fengjiao, Lu, Charles, Robinson, Kenneth, Quarless, Danjuma, Warder, Scott E., Mukherjee, Nabanita, Pesko, John, Souers, Andrew J., Waring, Jeffrey F., Davids, Matthew S., Tausch, Eugen, Stilgenbauer, Stephan, Ross, Jeremy A., Leverson, Joel D., Kim, Su Young, Chyla, Brenda J.
Published in American journal of hematology (01.02.2022)
Published in American journal of hematology (01.02.2022)
Get full text
Journal Article
Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity
Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M, Park, Chang H, Boghaert, Erwin R, Catron, Nathaniel D, Chen, Jun, Colman, Peter M, Czabotar, Peter E, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Hymowitz, Sarah G, Jin, Sha, Judge, Russell A, Koehler, Michael F. T, Kovar, Peter J, Lessene, Guillaume, Mitten, Michael J, Ndubaku, Chudi O, Nimmer, Paul, Purkey, Hans E, Oleksijew, Anatol, Phillips, Darren C, Sleebs, Brad E, Smith, Brian J, Smith, Morey L, Tahir, Stephen K, Watson, Keith G, Xiao, Yu, Xue, John, Zhang, Haichao, Zobel, Kerry, Rosenberg, Saul H, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J
Published in ACS medicinal chemistry letters (09.10.2014)
Published in ACS medicinal chemistry letters (09.10.2014)
Get full text
Journal Article
Venetoclax-based Rational Combinations are Effective in Models of MYCN -amplified Neuroblastoma
Dalton, Krista M, Krytska, Kateryna, Lochmann, Timothy L, Sano, Renata, Casey, Colleen, D'Aulerio, Alessia, Khan, Qasim A, Crowther, Giovanna Stein, Coon, Colin, Cai, Jinyang, Jacob, Sheeba, Kurupi, Richard, Hu, Bin, Dozmorov, Mikhail, Greninger, Patricia, Souers, Andrew J, Benes, Cyril H, Mossé, Yael P, Faber, Anthony C
Published in Molecular cancer therapeutics (01.08.2021)
Published in Molecular cancer therapeutics (01.08.2021)
Get full text
Journal Article
The role of lymphatic transport on the systemic bioavailability of the Bcl-2 protein family inhibitors navitoclax (ABT-263) and ABT-199
Choo, Edna F, Boggs, Jason, Zhu, Chunqiang, Lubach, Joseph W, Catron, Nathaniel D, Jenkins, Gary, Souers, Andrew J, Voorman, Richard
Published in Drug metabolism and disposition (01.02.2014)
Published in Drug metabolism and disposition (01.02.2014)
Get full text
Journal Article
Genomic analysis and selective small molecule inhibition identifies BCL-XL as a critical survival factor in a subset of colorectal cancer
Zhang, Haichao, Xue, John, Hessler, Paul, Tahir, Stephen K, Chen, Jun, Jin, Sha, Souers, Andrew J, Leverson, Joel D, Lam, Lloyd T
Published in Molecular cancer (02.07.2015)
Published in Molecular cancer (02.07.2015)
Get full text
Journal Article
The Ewing Family of Tumors Relies on BCL-2 and BCL-X L to Escape PARP Inhibitor Toxicity
Heisey, Daniel A R, Lochmann, Timothy L, Floros, Konstantinos V, Coon, Colin M, Powell, Krista M, Jacob, Sheeba, Calbert, Marissa L, Ghotra, Maninderjit S, Stein, Giovanna T, Maves, Yuki Kato, Smith, Steven C, Benes, Cyril H, Leverson, Joel D, Souers, Andrew J, Boikos, Sosipatros A, Faber, Anthony C
Published in Clinical cancer research (01.03.2019)
Published in Clinical cancer research (01.03.2019)
Get full text
Journal Article
Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy
Floros, Konstantinos V., Lochmann, Timothy L., Hu, Bin, Monterrubio, Carles, Hughes, Mark T., Wells, Jason D., Morales, Cristina Bernadó, Ghotra, Maninderjit S., Costa, Carlotta, Souers, Andrew J., Boikos, Sosipatros A., Leverson, Joel D., Tan, Ming, Serra, Violeta, Koblinski, Jennifer E., Arribas, Joaquin, Prat, Aleix, Paré, Laia, Miller, Todd W., Dozmorov, Mikhail G., Harada, Hisashi, Windle, Brad E., Scaltriti, Maurizio, Faber, Anthony C.
Published in Proceedings of the National Academy of Sciences - PNAS (13.03.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (13.03.2018)
Get full text
Journal Article
Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers
Salem, Ahmed Hamed, Tao, Zhi-Fu, Bueno, Orlando F, Chen, Jie, Chen, Shuang, Edalji, Rohinton, Elmore, Steven W, Fournier, Keith M, Harper, Kaid C, Hong, Richard, Jenkins, Gary J, Ji, Jianguo, Judge, Russell A, Kalvass, John C, Klix, Russell C, Ku, Yi-Yin, Leverson, Joel D, Marks, Richard A, Marsh, Kennan C, Menon, Rajeev M, Park, Chang H, Phillips, Darren C, Pu, Yu-Ming, Rosenberg, Saul H, Sanzgiri, Yeshwant D, Sheikh, Ahmad Y, Shi, Yi, Stolarik, Deanne, Suleiman, Ahmed A, Wang, Xilu, Zhang, Geoff G Z, Catron, Nathaniel D, Souers, Andrew J
Published in Molecular cancer therapeutics (01.06.2021)
Published in Molecular cancer therapeutics (01.06.2021)
Get full text
Journal Article
Structure-Based Design of A-1293102, a Potent and Selective BCL-X-L Inhibitor
Tao, Zhi-Fu, Wang, Xilu, Chen, Jun, Ingram, Justin P., Jin, Sha, Judge, Russell A., Kovar, Peter J., Park, Chang, Sun, Chaohong, Wakefield, Brian D., Zhou, Li, Zhang, Haichao, Elmore, Steven W., Phillips, Darren C., Judd, Andrew S., Leverson, Joel D., Souers, Andrew J.
Published in ACS medicinal chemistry letters (10.06.2021)
Published in ACS medicinal chemistry letters (10.06.2021)
Get full text
Journal Article
Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3
Souers, Andrew J., Wodka, Dariusz, Gao, Ju, Lewis, Jared C., Vasudevan, Anil, Brodjian, Sevan, Dayton, Brian, Ogiela, Christopher A., Fry, Dennis, Hernandez, Lisa E., Marsh, Kennan C., Collins, Christine A., Kym, Philip R.
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
Get full text
Journal Article