From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations
Veit, Gudio, Avramescu, Radu G, Chiang, Annette N, Houck, Scott A, Cai, Zhiwei, Peters, Kathryn W, Hong, Jeong S, Pollard, Harvey B, Guggino, William B, Balch, William E, Skach, William R, Cutting, Garry R, Frizzell, Raymond A, Sheppard, David N, Cyr, Douglas M, Sorscher, Eric J, Brodsky, Jeffrey L, Lukacs, Gergely L
Published in Molecular biology of the cell (01.02.2016)
Published in Molecular biology of the cell (01.02.2016)
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Mutation accumulation in H. sapiens F508del CFTR countermands dN/dS type genomic analysis
Hong, Jeong S, Tindall, Janice M, Tindall, Samuel R, Sorscher, Eric J
Published in PloS one (18.07.2024)
Published in PloS one (18.07.2024)
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A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease
Sloane, Peter A, Shastry, Suresh, Wilhelm, Andrew, Courville, Clifford, Tang, Li Ping, Backer, Kyle, Levin, Elina, Raju, S Vamsee, Li, Yao, Mazur, Marina, Byan-Parker, Suzanne, Grizzle, William, Sorscher, Eric J, Dransfield, Mark T, Rowe, Steven M
Published in PloS one (29.06.2012)
Published in PloS one (29.06.2012)
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Method for quantitative study of airway functional microanatomy using micro-optical coherence tomography
Liu, Linbo, Chu, Kengyeh K, Houser, Grace H, Diephuis, Bradford J, Li, Yao, Wilsterman, Eric J, Shastry, Suresh, Dierksen, Gregory, Birket, Susan E, Mazur, Marina, Byan-Parker, Suzanne, Grizzle, William E, Sorscher, Eric J, Rowe, Steven M, Tearney, Guillermo J
Published in PloS one (23.01.2013)
Published in PloS one (23.01.2013)
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A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Sharma, Jyoti, Du, Ming, Wong, Eric, Mutyam, Venkateshwar, Li, Yao, Chen, Jianguo, Wangen, Jamie, Thrasher, Kari, Fu, Lianwu, Peng, Ning, Tang, Liping, Liu, Kaimao, Mathew, Bini, Bostwick, Robert J, Augelli-Szafran, Corinne E, Bihler, Hermann, Liang, Feng, Mahiou, Jerome, Saltz, Josef, Rab, Andras, Hong, Jeong, Sorscher, Eric J, Mendenhall, Eric M, Coppola, Candice J, Keeling, Kim M, Green, Rachel, Mense, Martin, Suto, Mark J, Rowe, Steven M, Bedwell, David M
Published in Nature communications (16.07.2021)
Published in Nature communications (16.07.2021)
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Translation velocity determines the efficacy of engineered suppressor tRNAs on pathogenic nonsense mutations
Bharti, Nikhil, Santos, Leonardo, Davyt, Marcos, Behrmann, Stine, Eichholtz, Marie, Jimenez-Sanchez, Alejandro, Hong, Jeong S, Rab, Andras, Sorscher, Eric J, Albers, Suki, Ignatova, Zoya
Published in Nature communications (05.04.2024)
Published in Nature communications (05.04.2024)
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Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats
Tuggle, Katherine L, Birket, Susan E, Cui, Xiaoxia, Hong, Jeong, Warren, Joe, Reid, Lara, Chambers, Andre, Ji, Diana, Gamber, Kevin, Chu, Kengyeh K, Tearney, Guillermo, Tang, Li Ping, Fortenberry, James A, Du, Ming, Cadillac, Joan M, Bedwell, David M, Rowe, Steven M, Sorscher, Eric J, Fanucchi, Michelle V
Published in PloS one (07.03.2014)
Published in PloS one (07.03.2014)
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Relationships between genomic dissipation and de novo SNP evolution
Plyler, Zackery E, McAtee, Christopher W, Hill, Aubrey E, Crowley, Michael R, Tindall, Janice M, Tindall, Samuel R, Joshi, Disha, Sorscher, Eric J
Published in PloS one (16.05.2024)
Published in PloS one (16.05.2024)
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Journal Article
Ivacaftor Reverses Airway Mucus Abnormalities in a Rat Model Harboring a Humanized G551D-CFTR
Birket, Susan E, Davis, Joy M, Fernandez-Petty, Courtney M, Henderson, Alexander G, Oden, Ashley M, Tang, LiPing, Wen, Hui, Hong, Jeong, Fu, Lianwu, Chambers, Andre, Fields, Alvin, Zhao, Gojun, Tearney, Guillermo J, Sorscher, Eric J, Rowe, Steven M
Published in American journal of respiratory and critical care medicine (01.11.2020)
Published in American journal of respiratory and critical care medicine (01.11.2020)
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Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells
Crane, Ana M, Kramer, Philipp, Bui, Jacquelin H, Chung, Wook Joon, Li, Xuan Shirley, Gonzalez-Garay, Manuel L, Hawkins, Finn, Liao, Wei, Mora, Daniela, Choi, Sangbum, Wang, Jianbin, Sun, Helena C, Paschon, David E, Guschin, Dmitry Y, Gregory, Philip D, Kotton, Darrell N, Holmes, Michael C, Sorscher, Eric J, Davis, Brian R
Published in Stem cell reports (14.04.2015)
Published in Stem cell reports (14.04.2015)
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Myofibroblast differentiation and enhanced TGF-B signaling in cystic fibrosis lung disease
Harris, William T, Kelly, David R, Zhou, Yong, Wang, Dezhi, MacEwen, Mark, Macewen, Mark, Hagood, James S, Clancy, J P, Ambalavanan, Namasivayam, Sorscher, Eric J
Published in PloS one (12.08.2013)
Published in PloS one (12.08.2013)
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Journal Article
Trafficking and function of the cystic fibrosis transmembrane conductance regulator: a complex network of posttranslational modifications
McClure, Michelle L, Barnes, Stephen, Brodsky, Jeffrey L, Sorscher, Eric J
Published in American journal of physiology. Lung cellular and molecular physiology (01.10.2016)
Published in American journal of physiology. Lung cellular and molecular physiology (01.10.2016)
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Journal Article
Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators
Wang, Wei, Hong, Jeong S, Rab, Andras, Sorscher, Eric J, Kirk, Kevin L
Published in PloS one (23.03.2016)
Published in PloS one (23.03.2016)
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Reduced bone length, growth plate thickness, bone content, and IGF-I as a model for poor growth in the CFTR-deficient rat
Stalvey, Michael S, Havasi, Viktoria, Tuggle, Katherine L, Wang, Dezhi, Birket, Susan, Rowe, Steve M, Sorscher, Eric J
Published in PloS one (30.11.2017)
Published in PloS one (30.11.2017)
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A medium composition containing normal resting glucose that supports differentiation of primary human airway cells
Morgan, Rachel, Manfredi, Candela, Easley, Kristen F, Watkins, Lionel D, Hunt, William R, Goudy, Steven L, Sorscher, Eric J, Koval, Michael, Molina, Samuel A
Published in Scientific reports (27.01.2022)
Published in Scientific reports (27.01.2022)
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Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance
Zhang, Shaoyan, Skinner, Daniel, Hicks, Stephen Bradley, Bevensee, Mark O, Sorscher, Eric J, Lazrak, Ahmed, Matalon, Sadis, McNicholas, Carmel M, Woodworth, Bradford A
Published in PloS one (12.08.2014)
Published in PloS one (12.08.2014)
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Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis
Balch, William E, Hutt, Darren M, Herman, David, Rodrigues, Ana P C, Noel, Sabrina, Pilewski, Joseph M, Matteson, Jeanne, Hoch, Ben, Kellner, Wendy, Kelly, Jeffery W, Schmidt, Andre, Thomas, Philip J, Matsumura, Yoshihiro, Skach, William R, Gentzsch, Martina, Riordan, John R, Sorscher, Eric J, Okiyoneda, Tsukasa, Yates, John R, Lukacs, Gergely L, Frizzell, Raymond A, Manning, Gerard, Gottesfeld, Joel M
Published in Nature chemical biology (01.01.2010)
Published in Nature chemical biology (01.01.2010)
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Assessing cell-specific effects of genetic variations using tRNA microarrays
Polte, Christine, Wedemeyer, Daniel, Oliver, Kathryn E, Wagner, Johannes, Bijvelds, Marcel J C, Mahoney, John, de Jonge, Hugo R, Sorscher, Eric J, Ignatova, Zoya
Published in BMC genomics (16.07.2019)
Published in BMC genomics (16.07.2019)
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Journal Article
Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect
Veit, Guido, Oliver, Kathryn, Apaja, Pirjo M, Perdomo, Doranda, Bidaud-Meynard, Aurélien, Lin, Sheng-Ting, Guo, Jingyu, Icyuz, Mert, Sorscher, Eric J, Hartman, IV, John L, Lukacs, Gergely L
Published in PLoS biology (01.05.2016)
Published in PLoS biology (01.05.2016)
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