Calpain research for drug discovery: challenges and potential
Ono, Yasuko, Saido, Takaomi C, Sorimachi, Hiroyuki
Published in Nature reviews. Drug discovery (01.12.2016)
Published in Nature reviews. Drug discovery (01.12.2016)
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Journal Article
Impact of genetic insights into calpain biology
Sorimachi, Hiroyuki, Hata, Shoji, Ono, Yasuko
Published in Journal of biochemistry (Tokyo) (01.07.2011)
Published in Journal of biochemistry (Tokyo) (01.07.2011)
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Journal Article
The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3
Ishimura, Ryosuke, El-Gowily, Afnan H, Noshiro, Daisuke, Komatsu-Hirota, Satoko, Ono, Yasuko, Shindo, Mayumi, Hatta, Tomohisa, Abe, Manabu, Uemura, Takefumi, Lee-Okada, Hyeon-Cheol, Mohamed, Tarek M, Yokomizo, Takehiko, Ueno, Takashi, Sakimura, Kenji, Natsume, Tohru, Sorimachi, Hiroyuki, Inada, Toshifumi, Waguri, Satoshi, Noda, Nobuo N, Komatsu, Masaaki
Published in Nature communications (21.12.2022)
Published in Nature communications (21.12.2022)
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Journal Article
Calpain cleavage prediction using multiple kernel learning
DuVerle, David A, Ono, Yasuko, Sorimachi, Hiroyuki, Mamitsuka, Hiroshi
Published in PloS one (03.05.2011)
Published in PloS one (03.05.2011)
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Journal Article
Structure, Activation, and Biology of Calpain
SUZUKI, Koichi, HATA, Shoji, KAWABATA, Yukiko, SORIMACHI, Hiroyuki
Published in Diabetes (New York, N.Y.) (01.02.2004)
Published in Diabetes (New York, N.Y.) (01.02.2004)
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Journal Article
Conference Proceeding
A Gastrointestinal Calpain Complex, G-calpain, Is a Heterodimer of CAPN8 and CAPN9 Calpain Isoforms, Which Play Catalytic and Regulatory Roles, Respectively
Hata, Shoji, Kitamura, Fujiko, Yamaguchi, Midori, Shitara, Hiroshi, Murakami, Makoto, Sorimachi, Hiroyuki
Published in The Journal of biological chemistry (30.12.2016)
Published in The Journal of biological chemistry (30.12.2016)
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Journal Article
Collaboration between a cis-interacting natural killer cell receptor and membrane sphingolipid is critical for the phagocyte function
Karyu, Hitomi, Niki, Takahiro, Sorimachi, Yuriko, Hata, Shoji, Shimabukuro-Demoto, Shiho, Hirabayashi, Tetsuya, Mukai, Kojiro, Kasahara, Kohji, Takubo, Keiyo, Goda, Nobuhito, Honke, Koichi, Taguchi, Tomohiko, Sorimachi, Hiroyuki, Toyama-Sorimachi, Noriko
Published in Frontiers in immunology (24.04.2024)
Published in Frontiers in immunology (24.04.2024)
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Journal Article
Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing
Miyazaki, Takuro, Tonami, Kazuo, Hata, Shoji, Aiuchi, Toshihiro, Ohnishi, Koji, Lei, Xiao-Feng, Kim-Kaneyama, Joo-Ri, Takeya, Motohiro, Itabe, Hiroyuki, Sorimachi, Hiroyuki, Kurihara, Hiroki, Miyazaki, Akira
Published in The Journal of clinical investigation (01.09.2016)
Published in The Journal of clinical investigation (01.09.2016)
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Journal Article
Predictions of Cleavability of Calpain Proteolysis by Quantitative Structure-Activity Relationship Analysis Using Newly Determined Cleavage Sites and Catalytic Efficiencies of an Oligopeptide Array
Shinkai-Ouchi, Fumiko, Koyama, Suguru, Ono, Yasuko, Hata, Shoji, Ojima, Koichi, Shindo, Mayumi, duVerle, David, Ueno, Mika, Kitamura, Fujiko, Doi, Naoko, Takigawa, Ichigaku, Mamitsuka, Hiroshi, Sorimachi, Hiroyuki
Published in Molecular & cellular proteomics (01.04.2016)
Published in Molecular & cellular proteomics (01.04.2016)
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Journal Article
The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation
Ono, Yasuko, Shindo, Mayumi, Doi, Naoko, Kitamura, Fujiko, Gregorio, Carol C., Sorimachi, Hiroyuki
Published in Proceedings of the National Academy of Sciences - PNAS (23.12.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (23.12.2014)
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Journal Article
Calpain-6 deficiency promotes skeletal muscle development and regeneration
Tonami, Kazuo, Hata, Shoji, Ojima, Koichi, Ono, Yasuko, Kurihara, Yukiko, Amano, Tomokazu, Sato, Takahiro, Kawamura, Yumiko, Kurihara, Hiroki, Sorimachi, Hiroyuki
Published in PLoS genetics (01.08.2013)
Published in PLoS genetics (01.08.2013)
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Journal Article
Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense
Hata, Shoji, Abe, Manabu, Suzuki, Hidenori, Kitamura, Fujiko, Toyama-Sorimachi, Noriko, Abe, Keiko, Sakimura, Kenji, Sorimachi, Hiroyuki
Published in PLoS genetics (01.07.2010)
Published in PLoS genetics (01.07.2010)
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Journal Article
Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy
Ojima, Koichi, Kawabata, Yukiko, Nakao, Harumi, Nakao, Kazuki, Doi, Naoko, Kitamura, Fujiko, Ono, Yasuko, Hata, Shoji, Suzuki, Hidenori, Kawahara, Hiroyuki, Bogomolovas, Julius, Witt, Christian, Ottenheijm, Coen, Labeit, Siegfried, Granzier, Henk, Toyama-Sorimachi, Noriko, Sorimachi, Michiko, Suzuki, Koichi, Maeda, Tatsuya, Abe, Keiko, Aiba, Atsu, Sorimachi, Hiroyuki
Published in The Journal of clinical investigation (01.08.2010)
Published in The Journal of clinical investigation (01.08.2010)
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Journal Article
Multiple Molecular Interactions Implicate the Connectin/Titin N2A Region as a Modulating Scaffold for p94/Calpain 3 Activity in Skeletal Muscle
Hayashi, Chikako, Ono, Yasuko, Doi, Naoko, Kitamura, Fujiko, Tagami, Mai, Mineki, Reiko, Arai, Takao, Taguchi, Hayao, Yanagida, Mitsuaki, Hirner, Stephanie, Labeit, Dietmar, Labeit, Siegfried, Sorimachi, Hiroyuki
Published in The Journal of biological chemistry (23.05.2008)
Published in The Journal of biological chemistry (23.05.2008)
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Journal Article