Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway
Ding, Chunyong, Song, Zilan, Shen, Ancheng, Chen, Tingting, Zhang, Ao
Published in Acta pharmaceutica Sinica. B (01.12.2020)
Published in Acta pharmaceutica Sinica. B (01.12.2020)
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Small-Molecule Immuno-Oncology Therapy: Advances, Challenges and New Directions
Chen, Shulun, Song, Zilan, Zhang, Ao
Published in Current topics in medicinal chemistry (01.01.2019)
Published in Current topics in medicinal chemistry (01.01.2019)
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Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance
Wang, Li‐Min, Wang, Pingyuan, Chen, Xiao‐Min, Yang, Hui, Song, Shan‐Shan, Song, Zilan, Jia, Li, Chen, Hua‐Dong, Bao, Xu‐Bin, Guo, Ne, Huan, Xia‐Juan, Xi, Yong, Shen, Yan‐Yan, Yang, Xin‐Ying, Su, Yi, Sun, Yi‐Ming, Gao, Ying‐Lei, Chen, Yi, Ding, Jian, Lang, Jing‐Yu, Miao, Ze‐Hong, Zhang, Ao, He, Jin‐Xue
Published in EMBO molecular medicine (08.03.2023)
Published in EMBO molecular medicine (08.03.2023)
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Novel tetracyclic benzo[b]carbazolones as highly potent and orally bioavailable ALK inhibitors: Design, synthesis, and structure—activity relationship study
Jiang, Xiaolong, Zhou, Ji, Ai, Jing, Song, Zilan, Peng, Xia, Xing, Li, Xi, Yong, Guo, Junfeng, Yao, Qizheng, Ding, Jian, Geng, Meiyu, Zhang, Ao
Published in European journal of medicinal chemistry (13.11.2015)
Published in European journal of medicinal chemistry (13.11.2015)
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Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage
Song, Zilan, Liu, Bo, Peng, Xia, Gu, Wangting, Sun, Yiming, Xing, Li, Xu, Yi, Geng, Meiyu, Ai, Jing, Zhang, Ao
Published in Journal of medicinal chemistry (25.11.2021)
Published in Journal of medicinal chemistry (25.11.2021)
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Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors
Xie, Chenghu, Liu, Bo, Song, Zilan, Yang, Ye, Dai, Mengdi, Gao, Yinglei, Yao, Yujia, Ding, Chunyong, Ai, Jing, Zhang, Ao
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRAS(G12C) inhibitors
Xiao, Xuanzheng, Lai, Mengzhen, Song, Zilan, Geng, Meiyu, Ding, Jian, Xie, Hua, Zhang, Ao
Published in European journal of medicinal chemistry (05.03.2021)
Published in European journal of medicinal chemistry (05.03.2021)
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Design, Synthesis, and Pharmacological Evaluation of Spiro[carbazole-3,3′-pyrrolidine] Derivatives as cGAS Inhibitors for Treatment of Acute Lung Injury
Chen, Mingjie, Lei, Shuyue, Zhou, Zihua, Wang, Meng, Feng, Chunlan, Gao, Xiaoling, Ding, Chunyong, Song, Zilan, Tang, Wei, Zhang, Ao
Published in Journal of medicinal chemistry (25.04.2024)
Published in Journal of medicinal chemistry (25.04.2024)
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Structure–Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists
Song, Zilan, Wang, Xiyuan, Zhang, Yan, Gu, Wangting, Shen, Ancheng, Ding, Chunyong, Li, Han, Xiao, Ruoxuan, Geng, Meiyu, Xie, Zuoquan, Zhang, Ao
Published in Journal of medicinal chemistry (11.02.2021)
Published in Journal of medicinal chemistry (11.02.2021)
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Structural Modification and Pharmacological Evaluation of Substituted Quinoline-5,8-diones as Potent NSD2 Inhibitors
Tang, Hairong, Yu, Aisong, Xing, Li, Chen, Xiaoyu, Ding, Huaqian, Yang, Hong, Song, Zilan, Shi, Qiongyu, Geng, Meiyu, Huang, Xun, Zhang, Ao
Published in Journal of medicinal chemistry (26.01.2023)
Published in Journal of medicinal chemistry (26.01.2023)
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Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90–Kinase Interactions
Wang, Meining, Shen, Aijun, Zhang, Chi, Song, Zilan, Ai, Jing, Liu, Hongchun, Sun, Liping, Ding, Jian, Geng, Meiyu, Zhang, Ao
Published in Journal of medicinal chemistry (23.06.2016)
Published in Journal of medicinal chemistry (23.06.2016)
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Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[d]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD)
Zeng, Ruoqing, Fang, Meimiao, Shen, Ancheng, Chai, Xiaolei, Zhao, Yumiao, Liu, Mingyao, Zhu, Lingfeng, Rui, Weiwei, Feng, Bo, Hong, Liang, Ding, Chunyong, Song, Zilan, Lu, Weiqiang, Zhang, Ao
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors
Wei, Manman, Peng, Xia, Xing, Li, Dai, Yang, Huang, Ruimin, Geng, Meiyu, Zhang, Ao, Ai, Jing, Song, Zilan
Published in European journal of medicinal chemistry (25.06.2018)
Published in European journal of medicinal chemistry (25.06.2018)
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Structure−Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists
Shen, Ancheng, Li, Xiyuan, Zhang, Yan, Ma, Jing, Xiao, Ruoxuan, Wang, Xiyuan, Song, Zilan, Liu, Zhiguo, Geng, Meiyu, Zhang, Ao, Xie, Zuoquan, Ding, Chunyong
Published in European journal of medicinal chemistry (05.11.2022)
Published in European journal of medicinal chemistry (05.11.2022)
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Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs
Geng, Kaijun, Liu, Hongchun, Song, Zilan, Zhang, Chi, Zhang, Minmin, Yang, Hong, Cao, Jingchen, Geng, Meiyu, Shen, Aijun, Zhang, Ao
Published in European journal of medicinal chemistry (25.05.2018)
Published in European journal of medicinal chemistry (25.05.2018)
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Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRASG12C inhibitors
Xiao, Xuanzheng, Lai, Mengzhen, Song, Zilan, Geng, Meiyu, Ding, Jian, Xie, Hua, Zhang, Ao
Published in European journal of medicinal chemistry (05.03.2021)
Published in European journal of medicinal chemistry (05.03.2021)
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Discovery of a potent tyrosine kinase AXL inhibitor bearing the 3-((2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrazine core
Wang, Yueliang, Xing, Li, Ji, Yinchun, Ye, Jiqing, Dai, Yang, Gu, Wangting, Ai, Jing, Song, Zilan
Published in Bioorganic & medicinal chemistry letters (15.03.2019)
Published in Bioorganic & medicinal chemistry letters (15.03.2019)
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(D,L)-10-Camphorsulfonic-Acid-Catalysed Synthesis of Diaryl-Fused 2,8-Dioxabicyclo[3.3.1]nonanes from 2-Hydroxychalcones and Naphthol Derivatives
Jiang, Xiaolong, Song, Zilan, Xu, Chang, Yao, Qizheng, Zhang, Ao
Published in European journal of organic chemistry (01.01.2014)
Published in European journal of organic chemistry (01.01.2014)
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Synthesis and structure–activity relationship study of pyrazolo[3,4-d]pyrimidines as tyrosine kinase RET inhibitors
Wang, Chengyan, Liu, Hongchun, Song, Zilan, Ji, Yinchun, Xing, Li, Peng, Xia, Wang, Xisheng, Ai, Jing, Geng, Meiyu, Zhang, Ao
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
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