Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity
Gong, Hua, Weinstein, David S., Lu, Zhonghui, Duan, James J.-W., Stachura, Sylwia, Haque, Lauren, Karmakar, Ananta, Hemagiri, Hemalatha, Raut, Dhanya Kumar, Gupta, Arun Kumar, Khan, Javed, Camac, Dan, Sack, John S., Pudzianowski, Andrew, Wu, Dauh-Rurng, Yarde, Melissa, Shen, Ding-Ren, Borowski, Virna, Xie, Jenny H., Sun, Huadong, D'Arienzo, Celia, Dabros, Marta, Galella, Michael A., Wang, Faye, Weigelt, Carolyn A., Zhao, Qihong, Foster, William, Somerville, John E., Salter-Cid, Luisa M., Barrish, Joel C., Carter, Percy H., Dhar, T.G. Murali
Published in Bioorganic & medicinal chemistry letters (15.01.2018)
Published in Bioorganic & medicinal chemistry letters (15.01.2018)
Get full text
Journal Article
Development of a Molecular Signature to Monitor Pharmacodynamic Responses Mediated by In Vivo Administration of Glucocorticoids
Hu, Yanhua, Carman, Julie A., Holloway, Deborah, Kansal, Selena, Fan, Li, Goldstine, Christine, Lee, Deborah, Somerville, John E., Latek, Robert, Townsend, Robert, Johnsen, Alyssa, Connolly, Sean, Bandyopadhyay, Somnath, Shadick, Nancy, Weinblatt, Michael E., Furie, Richard, Nadler, Steven G.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.08.2018)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.08.2018)
Get full text
Journal Article
Azaxanthene Based Selective Glucocorticoid Receptor Modulators: Design, Synthesis, and Pharmacological Evaluation of (S)-4-(5-(1-((1,3,4-Thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and Its Methylene Homologue (BMS-791826)
Weinstein, David S, Gong, Hua, Doweyko, Arthur M, Cunningham, Mark, Habte, Sium, Wang, Jin Hong, Holloway, Deborah A, Burke, Christine, Gao, Ling, Guarino, Victor, Carman, Julie, Somerville, John E, Shuster, David, Salter-Cid, Luisa, Dodd, John H, Nadler, Steven G, Barrish, Joel C
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
Get full text
Journal Article
Antagonists of CCR4 as immunomodulatory agents
Purandare, Ashok V, Somerville, John E
Published in Current topics in medicinal chemistry (01.07.2006)
Published in Current topics in medicinal chemistry (01.07.2006)
Get more information
Journal Article
Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists
Gong, Hua, Yang, Michael, Xiao, Zili, Doweyko, Arthur M., Cunningham, Mark, Wang, Jinhong, Habte, Sium, Holloway, Deborah, Burke, Christine, Shuster, David, Gao, Ling, Carman, Julie, Somerville, John E., Nadler, Steven G., Salter-Cid, Luisa, Barrish, Joel C., Weinstein, David S.
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
Get full text
Journal Article
Improving the Pharmacokinetic and CYP Inhibition Profiles of Azaxanthene-Based Glucocorticoid Receptor ModulatorsIdentification of (S)‑5-(2-(9-Fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)‑5H‑chromeno[2,3‑b]pyridin-5-yl)-2-methylpropanamido)‑N‑(tetrahydro‑2H‑pyran-4-yl)-1,3,4-thiadiazole-2-carboxamide (BMS-341)
Yang, Michael G, Dhar, T. G. Murali, Xiao, Zili, Xiao, Hai-Yun, Duan, James J.-W, Jiang, Bin, Galella, Michael A, Cunningham, Mark, Wang, Jinhong, Habte, Sium, Shuster, David, McIntyre, Kim W, Carman, Julie, Holloway, Deborah A, Somerville, John E, Nadler, Steven G, Salter-Cid, Luisa, Barrish, Joel C, Weinstein, David S
Published in Journal of medicinal chemistry (28.05.2015)
Published in Journal of medicinal chemistry (28.05.2015)
Get full text
Journal Article
Dimethyl-diphenyl-propanamide Derivatives As Nonsteroidal Dissociated Glucocorticoid Receptor Agonists
Yang, Bingwei V, Weinstein, David S, Doweyko, Lidia M, Gong, Hua, Vaccaro, Wayne, Huynh, Tram, Xiao, Hai-yun, Doweyko, Arthur M, Mckay, Lorraine, Holloway, Deborah A, Somerville, John E, Habte, Sium, Cunningham, Mark, McMahon, Michele, Townsend, Robert, Shuster, David, Dodd, John H, Nadler, Steven G, Barrish, Joel C
Published in Journal of medicinal chemistry (09.12.2010)
Published in Journal of medicinal chemistry (09.12.2010)
Get full text
Journal Article
Novel Synthesis of the Hexahydroimidazo[1,5b]isoquinoline Scaffold: Application to the Synthesis of Glucocorticoid Receptor Modulators
Xiao, Hai-Yun, Wu, Dauh-Rurng, Malley, Mary F, Gougoutas, Jack Z, Habte, Sium F, Cunningham, Mark D, Somerville, John E, Dodd, John H, Barrish, Joel C, Nadler, Steven G, Dhar, T. G. Murali
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
Get full text
Journal Article
Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists
Sheppeck, James E., Gilmore, John L., Xiao, Hai-Yun, Dhar, T.G. Murali, Nirschl, David, Doweyko, Arthur M., Sack, Jack S., Corbett, Martin J., Malley, Mary F., Gougoutas, Jack Z., Mckay, Lorraine, Cunningham, Mark D., Habte, Sium F., Dodd, John H., Nadler, Steven G., Somerville, John E., Barrish, Joel C.
Published in Bioorganic & medicinal chemistry letters (01.10.2013)
Published in Bioorganic & medicinal chemistry letters (01.10.2013)
Get full text
Journal Article
Core exploration in optimization of chemokine receptor CCR4 antagonists
Purandare, Ashok V., Wan, Honghe, Somerville, John E., Burke, Christine, Vaccaro, Wayne, Yang, XiaoXia, McIntyre, Kim W., Poss, Michael A.
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Get full text
Journal Article
Heterocyclic glucocorticoid receptor modulators with a 2,2-dimethyl-3-phenyl-N-(thiazol or thiadiazol-2-yl)propanamide core
Xiao, Hai-Yun, Wu, Dauh-Rurng, Sheppeck, James E., Habte, Sium F., Cunningham, Mark D., Somerville, John E., Barrish, Joel C., Nadler, Steven G., Dhar, T.G. Murali
Published in Bioorganic & medicinal chemistry letters (15.10.2013)
Published in Bioorganic & medicinal chemistry letters (15.10.2013)
Get full text
Journal Article
Synthesis and structure–activity relationships of novel indazolyl glucocorticoid receptor partial agonists
Gilmore, John L., Sheppeck, James E., Wang, Jim, Dhar, T.G. Murali, Cavallaro, Cullen, Doweyko, Arthur M., Mckay, Lorraine, Cunningham, Mark D., Habte, Sium F., Nadler, Steven G., Dodd, John H., Somerville, John E., Barrish, Joel C.
Published in Bioorganic & medicinal chemistry letters (01.10.2013)
Published in Bioorganic & medicinal chemistry letters (01.10.2013)
Get full text
Journal Article
CD28 ligation increases macrophage suppression of T-cell proliferation
Silberman, Daniel, Bucknum, Amanda, Bartlett, Thomas, Composto, Gabriella, Kozlowski, Megan, Walker, Amanda, Werda, Amy, Cua, Jackelyn, Sharpe, Arlene H, Somerville, John E, Riggs, James E
Published in Cellular & molecular immunology (01.07.2012)
Published in Cellular & molecular immunology (01.07.2012)
Get full text
Journal Article
Expansion of B2 cells in the peritoneal cavity of PD-1−/− mice
Riggs, James Edward, Conti, Antonia, Maslanka, Jeffrey, Londregan, Jennifer, Somerville, John
Published in The Journal of immunology (1950) (01.05.2022)
Published in The Journal of immunology (1950) (01.05.2022)
Get full text
Journal Article
Loss of B1 and marginal zone B cells during ovarian cancer
Maslanka, Jeffrey, Torres, Gretel, Londregan, Jennifer, Goldman, Naomi, Silberman, Daniel, Somerville, John, Riggs, James E
Published in Cellular immunology (01.01.2024)
Published in Cellular immunology (01.01.2024)
Get full text
Journal Article
Phytohemagglutinin activates CD8 T cells in a model of the tumor microenvironment
Riggs, James Edward, Lomakova, Yelizavet, Goldman, Naomi, Somerville, John
Published in The Journal of immunology (1950) (01.05.2018)
Published in The Journal of immunology (1950) (01.05.2018)
Get full text
Journal Article
IgD Ligation Promotes B Cell Proliferation in a Model of the Tumor Microenvironment
Riggs, James Edward, Londregan, Jennifer E., Goldman, Naomi, Somerville, John
Published in The Journal of immunology (1950) (01.05.2018)
Published in The Journal of immunology (1950) (01.05.2018)
Get full text
Journal Article
IgD ligation allows peritoneal cavity B cell proliferation
Londregan, Jennifer, Maslanka, Jeffrey, Goldman, Naomi, Somerville, John, Riggs, James E.
Published in Immunobiology (1979) (01.03.2022)
Published in Immunobiology (1979) (01.03.2022)
Get full text
Journal Article
CD28 Costimulates Suppression in an In Vitro Model of the Tumor Microenvironment
Silberman, Daniel, Student, Biology Department, Rider University, Lawrenceville, NJ, Bucknum, Amanda, Student, Biology Department, Rider University, Lawrenceville, NJ, Bloomfield, Tiffany, Student, Biology Department, Rider University, Lawrenceville, NJ, Somerville, John, Associate Scientist, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ, Reid, Jessica, Student, Biology Department, Rider University, Lawrenceville, NJ, Riggs, James, Professor of Biology, Biology Department, Rider University, Lawrenceville, NJ
Published in Clinical immunology (Orlando, Fla.) (01.01.2007)
Published in Clinical immunology (Orlando, Fla.) (01.01.2007)
Get full text
Journal Article