Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit
Busby, Robert W., Bryant, Alexander P., Bartolini, Wilmin P., Cordero, Etchell A., Hannig, Gerhard, Kessler, Marco M., Mahajan-Miklos, Shalina, Pierce, Christine M., Solinga, Robert M., Sun, Li Jing, Tobin, Jenny V., Kurtz, Caroline B., Currie, Mark G.
Published in European journal of pharmacology (15.12.2010)
Published in European journal of pharmacology (15.12.2010)
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Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation
Busby, Robert W, Kessler, Marco M, Bartolini, Wilmin P, Bryant, Alexander P, Hannig, Gerhard, Higgins, Carolyn S, Solinga, Robert M, Tobin, Jenny V, Wakefield, James D, Kurtz, Caroline B, Currie, Mark G
Published in The Journal of pharmacology and experimental therapeutics (01.01.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2013)
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Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase
Wales, Jessica A., Chen, Cheng-Yu, Breci, Linda, Weichsel, Andrzej, Bernier, Sylvie G., Sheppeck, James E., Solinga, Robert, Nakai, Takashi, Renhowe, Paul A., Jung, Joon, Montfort, William R.
Published in The Journal of biological chemistry (02.02.2018)
Published in The Journal of biological chemistry (02.02.2018)
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Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract
Bryant, Alexander P., Busby, Robert W., Bartolini, Wilmin P., Cordero, Etchell A., Hannig, Gerhard, Kessler, Marco M., Pierce, Christine M., Solinga, Robert M., Tobin, Jenny V., Mahajan-Miklos, Shalina, Cohen, Mitchell B., Kurtz, Caroline B., Currie, Mark G.
Published in Life sciences (1973) (08.05.2010)
Published in Life sciences (1973) (08.05.2010)
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Linaclotide activates guanylate cyclase‐C/cGMP/protein kinase‐II‐dependent trafficking of CFTR in the intestine
Ahsan, Md. Kaimul, Tchernychev, Boris, Kessler, Marco M., Solinga, Robert M., Arthur, David, Linde, Cristina I., Silos‐Santiago, Inmaculada, Hannig, Gerhard, Ameen, Nadia A.
Published in Physiological reports (01.06.2017)
Published in Physiological reports (01.06.2017)
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MRP4 Modulation of the Guanylate Cyclase-C/cGMP Pathway: Effects on Linaclotide-Induced Electrolyte Secretion and cGMP Efflux
Tchernychev, Boris, Ge, Pei, Kessler, Marco M, Solinga, Robert M, Wachtel, Derek, Tobin, Jenny V, Thomas, Sara R, Lunte, Craig E, Fretzen, Angelika, Hannig, Gerhard, Bryant, Alexander P, Kurtz, Caroline B, Currie, Mark G, Silos-Santiago, Inmaculada
Published in The Journal of pharmacology and experimental therapeutics (01.10.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2015)
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Immunization with Staphylococcus aureus Clumping Factor B, a Major Determinant in Nasal Carriage, Reduces Nasal Colonization in a Murine Model
Schaffer, Adam C, Solinga, Robert M, Cocchiaro, Jordan, Portoles, Marta, Kiser, Kevin B, Risley, Allison, Randall, Suzanne M, Valtulina, Viviana, Speziale, Pietro, Walsh, Evelyn, Foster, Timothy, Lee, Jean C
Published in Infection and Immunity (01.04.2006)
Published in Infection and Immunity (01.04.2006)
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CD4⁺ T Cells and CXC Chemokines Modulate the Pathogenesis of Staphylococcus aureus Wound Infections
McLoughlin, Rachel M., Solinga, Robert M., Rich, Jeremy, Zaleski, Kathleen J., Cocchiaro, Jordan L., Risley, Allison, Tzianabos, Arthur O., Lee, Jean C.
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2006)
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Characterization of the Structure and Biological Functions of a Capsular Polysaccharide Produced by Staphylococcus saprophyticus
PARK, Sunny, KELLEY, Kathryn A, VINOGRADOV, Evgeny, SOLINGA, Robert, WEIDENMAIER, Christopher, MISAWA, Yoshiki, LEE, Jean C
Published in Journal of Bacteriology (01.09.2010)
Published in Journal of Bacteriology (01.09.2010)
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The Natriuretic Peptide Uroguanylin Elicits Physiologic Actions Through 2 Distinct Topoisomers
Moss, Nicholas G, Riguera, Dorothy A, Solinga, Robert M, Kessler, Marco M, Zimmer, Daniel P, Arendshorst, William J, Currie, Mark G, Goy, Michael F
Published in Hypertension (Dallas, Tex. 1979) (01.05.2009)
Published in Hypertension (Dallas, Tex. 1979) (01.05.2009)
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Activation of guanylate cyclase-C attenuates stretch responses and sensitization of mouse colorectal afferents
Feng, Bin, Kiyatkin, Michael E, La, Jun-Ho, Ge, Pei, Solinga, Robert, Silos-Santiago, Inmaculada, Gebhart, Gerald F
Published in The Journal of neuroscience (05.06.2013)
Published in The Journal of neuroscience (05.06.2013)
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Tu1863 Linaclotide Induces Secretion of cGMP Into the Colonic Submucosal Layer: An In Vivo Microdialysis Study in Rats
Tobin, Jenny, Thomas, Sara, Solinga, Robert, Masferrer, Jaime L, Lunte, Craig, Silos-Santiago, Inmaculada
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2015)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2015)
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Mo1886 Regulation of Linaclotide-Induced cGMP and Electrolyte Secretion by Multidrug Resistance-Associated Protein 4 (MRP4)
Tchernychev, Boris, Ge, Pei, Wachtel, Derek, Solinga, Robert, Kessler, Marco, Ranganath, Sheila, Hannig, Gerhard, Silos-Santiago, Inmaculada
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2015)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2015)
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Tu1211 IW-9179, a Phosphopeptide Designed to Target the Upper Gastrointestinal Tract, Is More Potent at Acidic pH and Is Rapidly Metabolized In Vitro in Rodent Intestinal Fluid
Kessler, Marco, Solinga, Robert, Zimmer, Daniel, Forsyth, Sanjeev, Wachtel, Derek, Cali, Brian M, Currie, Mark G
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2015)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2015)
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THE NATRIURETIC PEPTIDE UROGUANYLIN ELICITS PHYSIOLOGIC ACTIONS THROUGH TWO DISTINCT TOPOISOMERS
Moss, Nicholas G., Rigeura, Dorothy A., Solinga, Robert M., Kessler, Marco M., Zimmer, Daniel P., Arendshorst, William J., Currie, Mark G., Goy, Michael F.
Published in Hypertension (Dallas, Tex. 1979) (16.03.2009)
Published in Hypertension (Dallas, Tex. 1979) (16.03.2009)
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