Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone
Yano, Akihiro, Tsutsumi, Shinji, Soga, Shiro, Lee, Min-Jung, Trepel, Jane, Osada, Hiroyuki, Neckers, Len
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2008)
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A Radicicol Derivative, KF58333, Inhibits Expression of Hypoxia‐inducible Factor‐1α and Vascular Endothelial Growth Factor, Angiogenesis and Growth of Human Breast Cancer Xenografts
Kurebayashi, Junichi, Otsuki, Takemi, Kurosumi, Masafumi, Soga, Shiro, Akinaga, Shiro, Sonoo, Hiroshi
Published in Cancer science (01.12.2001)
Published in Cancer science (01.12.2001)
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Conformational significance of EH21A1–A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity
Onodera, Hideyuki, Kaneko, Masami, Takahashi, Yuichi, Uochi, Yumiko, Funahashi, Jun, Nakashima, Takayuki, Soga, Shiro, Suzuki, Makoto, Ikeda, Shunichi, Yamashita, Yoshinori, Rahayu, Endang S., Kanda, Yutaka, Ichimura, Michio
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
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Radicicol Leads to Selective Depletion of Raf Kinase and Disrupts K-Ras-activated Aberrant Signaling Pathway
Soga, Shiro, Kozawa, Takako, Narumi, Hiroaki, Akinaga, Shiro, Irie, Kenji, Matsumoto, Kunihiro, Sharma, Sreenath V., Nakano, Hirofumi, Mizukami, Tamio, Hara, Mitsunobu
Published in The Journal of biological chemistry (09.01.1998)
Published in The Journal of biological chemistry (09.01.1998)
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Journal Article
New Molecular and Biological Mechanism of Antitumor Activities of KW-2478, a Novel Nonansamycin Heat Shock Protein 90 Inhibitor, in Multiple Myeloma Cells
NAKASHIMA, Takayuki, ISHII, Toshihiko, TAGAYA, Hisashi, SEIKE, Toshihiro, NAKAGAWA, Hiroshi, KANDA, Yutaka, AKINAGA, Shiro, SOGA, Shiro, SHIOTSU, Yukimasa
Published in Clinical cancer research (15.05.2010)
Published in Clinical cancer research (15.05.2010)
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Journal Article
UCF76 Compounds, New Inhibitors of Farnesyltransferase Produced by Steptomyces
KARA, MITSUNOBU, SOGA, SHIRO, SHONO, KENZO, EISHIMA, JUN, MIZUKAMI, TAMIO
Published in Journal of antibiotics (2001)
Published in Journal of antibiotics (2001)
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UCF76 Compounds, New Inhibitors of Farnesyltransferase Produced by Streptomyces
KARA, MITSUNOBU, SOGA, SHIRO, SHONO, KENZO, EISHIMA, JUN, MIZUKAMI, TAMIO
Published in Journal of antibiotics (01.02.2001)
Published in Journal of antibiotics (01.02.2001)
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UCF116, New Inhibitors of Farnesyltransferase Produced by Streptomyces
HARA, MITSUNOBU, SOGA, SHIRO, ITOH, MIKITO, SHONO, KENZO, EISHIMA, JUN, MIZUKAMI, TAMIO
Published in Journal of antibiotics (2000)
Published in Journal of antibiotics (2000)
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Development of radicicol analogues
Soga, Shiro, Shiotsu, Yukimasa, Akinaga, Shiro, Sharma, Sreenath V
Published in Current cancer drug targets (01.10.2003)
Published in Current cancer drug targets (01.10.2003)
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Abstract 920: KW-2450, a novel IGF-1R/IR inhibitor, enhances the antitumor effect of lapatinib, letrozole or 4-hydroxy-tamoxifen in breast cancer cells
Umehara, Hiroshi, Koizumi, Fumito, Maekawa, Yoshimi, Shimizu, Makiko, Nakamura, Hiroaki, Ota, Toshio, Nara, Shinji, Takahashi, Takeshi, Kanda, Yutaka, Shiraishi, Norihiko, Akinaga, Shiro, Shiotsu, Yukimasa, Soga, Shiro
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Abstract 2636: Preclinical evaluation of the Hsp90 inhibitor KW-2478 in combination with bortezomib as a treatment for multiple myeloma
Ishii, Toshihiko, Nakashima, Takayuki, Seike, Toshihiro, Shudo, Aiko, Akinaga, Shiro, Soga, Shiro, Shiotsu, Yukimasa
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Journal Article
Antibiotic Radicicol Binds to the N-Terminal Domain of Hsp90 and Shares Important Biologic Activities with Geldanamycin
Schulte, Theodor W., Akinaga, Shiro, Soga, Shiro, Sullivan, William, Stensgard, Bridget, Toft, David, Neckers, Leonard M.
Published in Cell stress & chaperones (01.06.1998)
Published in Cell stress & chaperones (01.06.1998)
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Abstract 3605: KW-2450, a novel orally-active dual IGF1R/IR inhibitor: Antitumor effects in vitro and in vivo
Maekawa, Yoshimi, Koizumi, Fumito, Kashima, Naomi, Suzuki, Masayo, Umehara, Hiroshi, Takahashi, Hiroko, Nakamura, Hiroaki, Nara, Shinji, Nakazato, Tomoyuki, Kanda, Yutaka, Takahashi, Takeshi, Akinaga, Shiro, Shiotsu, Yukimasa, Soga, Shiro
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential
Tanaka, Rieko, Rubio, Almudena, Harn, Nancy K., Gernert, Douglas, Grese, Timothy A., Eishima, Jun, Hara, Mitsunobu, Yoda, Nobuyuki, Ohashi, Rui, Kuwabara, Takashi, Soga, Shiro, Akinaga, Shiro, Nara, Shinji, Kanda, Yutaka
Published in Bioorganic & medicinal chemistry (01.02.2007)
Published in Bioorganic & medicinal chemistry (01.02.2007)
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Journal Article
Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone
Yano, Akihiro, Tsutsumi, Shinji, Soga, Shiro, Lee, Min-Jung, Trepel, Jane, Osada, Hiroyuki, Neckers, Len
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2008)
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Journal Article
KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules
SOGA, S, NECKERS, L. M, AKINAGA, S, SCHULTE, T. W, SHIOTSU, Y, AKASAKA, K, NARUMI, H, AGATSUMA, T, IKUINA, Y, MURAKATA, C, TAMAOKI, T
Published in Cancer research (Chicago, Ill.) (15.06.1999)
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Published in Cancer research (Chicago, Ill.) (15.06.1999)
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Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G1 phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex
Shiotsu, Yukimasa, Neckers, Leonard M., Wortman, Ivo, An, Won G., Schulte, Theodor W., Soga, Shiro, Murakata, Chikara, Tamaoki, Tatsuya, Akinaga, Shiro
Published in Blood (15.09.2000)
Published in Blood (15.09.2000)
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