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Appleby, Todd C., Perry, Jason K., Murakami, Eisuke, Barauskas, Ona, Feng, Joy, Cho, Aesop, Fox, David, Wetmore, Diana R., McGrath, Mary E., Ray, Adrian S., Sofia, Michael J., Swaminathan, S., Edwards, Thomas E.
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Published in Science (American Association for the Advancement of Science) (13.02.2015)
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Park, Jang-June, Thi, Emily P., Carpio, Victor H., Bi, Yingzhi, Cole, Andrew G., Dorsey, Bruce D., Fan, Kristi, Harasym, Troy, Iott, Christina L., Kadhim, Salam, Kim, Jin Hyang, Lee, Amy C. H., Nguyen, Duyan, Paratala, Bhavna S., Qiu, Ruiqing, White, Andre, Lakshminarasimhan, Damodharan, Leo, Christopher, Suto, Robert K., Rijnbrand, Rene, Tang, Sunny, Sofia, Michael J., Moore, Chris B.
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Published in Nature communications (22.02.2021)
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Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977
Murakami, Eisuke, Tolstykh, Tatiana, Bao, Haiying, Niu, Congrong, Steuer, Holly M. Micolochick, Bao, Donghui, Chang, Wonsuk, Espiritu, Christine, Bansal, Shalini, Lam, Angela M., Otto, Michael J., Sofia, Michael J., Furman, Phillip A.
Published in The Journal of biological chemistry (05.11.2010)
Published in The Journal of biological chemistry (05.11.2010)
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Synthesis of Diastereomerically Pure Nucleotide Phosphoramidates
Ross, Bruce S, Ganapati Reddy, P, Zhang, Hai-Ren, Rachakonda, Suguna, Sofia, Michael J
Published in Journal of organic chemistry (21.10.2011)
Published in Journal of organic chemistry (21.10.2011)
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Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
MOSLEY, Ralph T, EDWARDS, Thomas E, MURAKAMI, Eisuke, LAM, Angela M, GRICE, Rena L, JINFA DU, SOFIA, Michael J, FURMAN, Philip A, OTTO, Michael J
Published in Journal of Virology (01.06.2012)
Published in Journal of Virology (01.06.2012)
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Preclinical Antiviral and Safety Profiling of the HBV RNA Destabilizer AB-161
Lam, Angela M, Dugyala, Ravi R, Sheraz, Muhammed, Liu, Fei, Thi, Emily P, Graves, Ingrid E, Cuconati, Andrea, Steuer, Holly Micolochick, Ardzinski, Andrzej, Overholt, Nathan, Mason, Jeremy D, Gotchev, Dimitar, Cole, Andrew G, Harasym, Troy O, Sofia, Michael J
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Published in Viruses (21.02.2024)
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PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication
LAM, Angela M, MURAKAMI, Eisuke, MORREY, John D, SMEE, Donald F, FRICK, David N, HECK, Julie A, PEIYUAN WANG, NAGARATHNAM, Dhanapalan, ROSS, Bruce S, SOFIA, Michael J, OTTO, Michael J, FURMAN, Phillip A, ESPIRITU, Christine, MICOLOCHICK STEUER, Holly M, NIU, Congrong, KEILMAN, Meg, HAIYING BAO, ZENNOU, Veronique, BOURNE, Nigel, JULANDER, Justin G
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
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An Efficient and Diastereoselective Synthesis of PSI-6130: A Clinically Efficacious Inhibitor of HCV NS5B Polymerase
Wang, Peiyuan, Chun, Byoung-Kwon, Rachakonda, Suguna, Du, Jinfa, Khan, Noshena, Shi, Junxing, Stec, Wojciech, Cleary, Darryl, Ross, Bruce S, Sofia, Michael J
Published in Journal of organic chemistry (04.09.2009)
Published in Journal of organic chemistry (04.09.2009)
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Safety, pharmacokinetics, and antiviral activity of the capsid inhibitor AB‐506 from Phase 1 studies in healthy subjects and those with hepatitis B
Yuen, Man‐Fung, Berliba, Elina, Sukeepaisarnjaroen, Wattana, Ahn, Sang Hoon, Tanwandee, Tawesak, Lim, Young‐Suk, Kim, Yoon Jun, Poovorawan, Kittiyod, Tangkijvanich, Pisit, Schwabe, Christian, Eley, Timothy, Brown, Joanne, Lee, Amy C. H., Thi, Emily P., Paratala, Bhavna, Mani, Nagraj, Sofia, Michael J., Picchio, Gaston, Sims, Karen D., Gane, Edward J.
Published in Hepatology communications (01.12.2022)
Published in Hepatology communications (01.12.2022)
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Hepatitis B Virus Therapeutic Agent ARB-1740 Has Inhibitory Effect on Hepatitis Delta Virus in a New Dually-Infected Humanized Mouse Model
Ye, Xin, Tateno, Chise, Thi, Emily P, Kakuni, Masakazu, Snead, Nicholas M, Ishida, Yuji, Barnard, Trisha R, Sofia, Michael J, Shimada, Takashi, Lee, Amy C. H
Published in ACS infectious diseases (10.05.2019)
Published in ACS infectious diseases (10.05.2019)
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Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance
Lam, Angela M, Edwards, Thomas E, Mosley, Ralph T, Murakami, Eisuke, Bansal, Shalini, Lugo, Christopher, Bao, Haiying, Otto, Michael J, Sofia, Michael J, Furman, Phillip A
Published in Antimicrobial agents and chemotherapy (01.11.2014)
Published in Antimicrobial agents and chemotherapy (01.11.2014)
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Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine
LAM, Angela M, ESPIRITU, Christine, VESELENAK, Ronald L, GANAPATI REDDY, P, CHANG, Wonsuk, JINFA DU, NAGARATHNAM, Dhanapalan, SOFIA, Michael J, OTTO, Michael J, FURMAN, Phillip A, MURAKAMI, Eisuke, ZENNOU, Veronique, BANSAL, Shalini, MICOLOCHICK STEUER, Holly M, CONGRONG NIU, KEILMAN, Meg, HAIYING BAO, BOURNE, Nigel
Published in Antimicrobial Agents and Chemotherapy (01.06.2011)
Published in Antimicrobial Agents and Chemotherapy (01.06.2011)
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Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938
CONGRONG NIU, TOLSTYKH, Tatiana, ZHANG, Hai-Ren, WOOLLY, Joseph, WANG, Li-Quan, CHAO, Piyun B, RAY, Adrian S, OTTO, Michael J, SOFIA, Michael J, FURMAN, Phillip A, MURAKAMI, Eisuke, HAIYING BAO, PARK, Yeojin, BABUSIS, Darius, LAM, Angela M, BANSAL, Shalini, JINFA DU, CHANG, Wonsuk, GANAPATI REDDY, P
Published in Antimicrobial Agents and Chemotherapy (01.07.2012)
Published in Antimicrobial Agents and Chemotherapy (01.07.2012)
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Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection
Chang, Wonsuk, Bao, Donghui, Chun, Byoung-Kwon, Naduthambi, Devan, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Reddy, P. Ganapati, Ross, Bruce S, Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine L, Keilman, Meg, Lam, Angela M, Niu, Congrong, Steuer, Holly Micolochick, Furman, Phillip A, Otto, Michael J, Sofia, Michael J
Published in ACS medicinal chemistry letters (10.02.2011)
Published in ACS medicinal chemistry letters (10.02.2011)
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Pregenomic RNA Launch Hepatitis B Virus Replication System Facilitates the Mechanistic Study of Antiviral Agents and Drug-Resistant Variants on Covalently Closed Circular DNA Synthesis
Zhao, Qiong, Chang, Jinhong, Rijnbrand, Rene, Lam, Angela M, Sofia, Michael J, Cuconati, Andrea, Guo, Ju-Tao
Published in Journal of virology (21.12.2022)
Published in Journal of virology (21.12.2022)
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