Effectiveness of opicapone in Parkinson's disease patients with motor fluctuations according to baseline use of entacapone: Findings from the real-world OPTIPARK study
Jost, Wolfgang, Reichmann, Heinz, Lees, Andrew, Marinho, Daniela, Magalhães, Diogo, Rocha, José, Soares-Da-Silva, Patrício
Published in Journal of the neurological sciences (01.10.2021)
Published in Journal of the neurological sciences (01.10.2021)
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Journal Article
Synthesis, Biological Evaluation, and Molecular Modeling Studies of a Novel, Peripherally Selective Inhibitor of Catechol-O-methyltransferase
Learmonth, David A, Palma, P. Nuno, Vieira-Coelho, Maria A, Soares-da-Silva, Patrício
Published in Journal of medicinal chemistry (02.12.2004)
Published in Journal of medicinal chemistry (02.12.2004)
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Journal Article
0581 Sleep Patterns and “OFF”-Time in Patients with Parkinson’s Disease and Motor Fluctuations
Hauser, Robert, Videnovic, Aleksandar, Soares-da-Silva, Patrício, Liang, Grace, Olson, Kurt, Jen, Eric, Rocha, José-Francisco, Klepitskaya, Olga
Published in Sleep (New York, N.Y.) (25.05.2022)
Published in Sleep (New York, N.Y.) (25.05.2022)
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AN INTEGRATED ASSESSMENT OF PHARMACOKINETICS AND PHARMACODYNAMICS OF ZAMICASTAT: A DOPAMINE Β-HYDROXYLASE INHIBITOR IN HEALTHY VOLUNTEERS
RONAGHINIA, AMIR, ROCHA, JOSE-FRANCISCO, MAGALHãES, PAULO, SANTOS, ANA, GAMA, HELENA, MAGALHAES, LUIS, PALMA, NUNO, FALCãO, AMíLCAR, SOARES-DA-SILVA, PATRICIO
Published in Chest (01.10.2021)
Published in Chest (01.10.2021)
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Journal Article
Pharmacokinetic-Pharmacodynamic Interaction between Nebicapone, a Novel Catechol-O-Methyltransferase Inhibitor, and Controlled-Release Levodopa/Carbidopa 200 mg/50 mg: Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Subjects
Vaz-da-Silva, Manuel, Loureiro, Ana I., Nunes, Teresa, Lopes, Carlos, Rocha, José, Machado, Rita, Costa, Raquel, Torrão, Leonel, Falcão, Amílcar, Wright, Lyndon, Almeida, Luis, Soares-da-Silva, Patrício
Published in Drugs in R&D (01.01.2008)
Published in Drugs in R&D (01.01.2008)
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Journal Article
Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/carbidopa
Almeida, Luis, Vaz-da-Silva, Manuel, Silveira, Pedro, Falcão, Amilcar, Maia, Joana, Loureiro, Ana, Torrão, Leonel, Machado, Rita, Wright, Lyndon, Soares-da-Silva, Patrício
Published in Clinical neuropharmacology (01.01.2004)
Published in Clinical neuropharmacology (01.01.2004)
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Journal Article
Study design to assess the effect of opicapone on levodopa pharmacokinetics in different levodopa-optimized treatment regimens in Parkinson's disease patients
Ferreira, Joaquim, Poewe, Werner, Rascol, Olivier, Stocchi, Fabrizio, Antonini, Angelo, Moreira, Joana, Rocha, José, Soares-Da-Silva, Patrício
Published in Journal of the neurological sciences (01.10.2021)
Published in Journal of the neurological sciences (01.10.2021)
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Journal Article
The epsilon (early Parkinson with L-dopa/DDCi and opicapone) study in early Parkinson's disease: Design and rationale of a phase III, double-blind, randomized, placebo-controlled study
Ferreira, Joaquim, Poewe, Werner, Rascol, Olivier, Stocchi, Fabrizio, Antonini, Angelo, Moreira, Joana, Rocha, José, Soares-Da-Silva, Patrício
Published in Journal of the neurological sciences (01.10.2021)
Published in Journal of the neurological sciences (01.10.2021)
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Journal Article
Adoption (early levodopa with opicapone in Parkinson's patients with motor fluctuations) study in Parkinson's disease: Design and rationale of a randomized prospective, open-label exploratory trial
Ferreira, Joaquim, Poewe, Werner, Rascol, Olivier, Stocchi, Fabrizio, Antonini, Angelo, Costa, Raquel, Magalhães, Diogo, Rocha, José, Soares-Da-Silva, Patrício
Published in Journal of the neurological sciences (01.10.2021)
Published in Journal of the neurological sciences (01.10.2021)
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Journal Article
Heart failure, aging, and renal synthesis of dopamine
Ferreira, A, Bettencourt, P, Pestana, M, Correia, F, Serrão, P, Martins, L, Cerqueira-Gomes, M, Soares-Da-Silva, P
Published in American journal of kidney diseases (01.09.2001)
Published in American journal of kidney diseases (01.09.2001)
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Journal Article
Chronopharmacology of nebicapone, a new catechol-O-methyltransferase inhibitor
Almeida, Luis, Loureiro, Ana I, Vaz-da-Silva, Manuel, Torrão, Leonel, Maia, Joana, Fernandes-Lopes, Carlos, Falcão, Amílcar, Igreja, Bruno, Wright, Lyndon, Soares-da-Silva, Patricio
Published in Current medical research and opinion (01.05.2010)
Published in Current medical research and opinion (01.05.2010)
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Journal Article
Abstract P238: Effect of Zamicastat in Chronic Treatment on Right Ventricle Pressure Overload in the Rat Monocrotaline Lung Injury Model of Pulmonary Hypertension
Igreja, Bruno, Pires, Nuno, Moser, Paul, Soares-da-Silva, Patrício
Published in Hypertension (Dallas, Tex. 1979) (01.09.2016)
Published in Hypertension (Dallas, Tex. 1979) (01.09.2016)
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Journal Article
In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein
Bicker, Joana, Alves, Gilberto, Fortuna, Ana, Soares-da-Silva, Patrício, Falcão, Amílcar
Published in European journal of pharmaceutical sciences (30.05.2018)
Published in European journal of pharmaceutical sciences (30.05.2018)
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Journal Article
The ocean (opicapone effect on motor fluctuations and associated pain) study in Parkinson's disease: Design and rationale of a randomized double-blind placebo-controlled trial
Chaudhuri, K. Ray, Odin, Per, Ferreira, Joaquim, Antonini, Angelo, Rascol, Olivier, Kurtis, Mónica, Storch, Alexander, Bannister, Kirsty, Costa, Raquel, Magalhães, Diogo, Rocha, José, Soares-Da-Silva, Patrício
Published in Journal of the neurological sciences (01.10.2021)
Published in Journal of the neurological sciences (01.10.2021)
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Journal Article
Involvement of g protein-coupled receptor kinase 4 and 6 in rapid desensitization fo dopamine d1 receptor in rat IEC-6 intestinal epithelial cells
Fraga, Sonia, Jose, Pedro A, Soares-da-Silva, Patricio
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.10.2004)
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Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.10.2004)
Journal Article
Pharmacokinetic--pharmacodynamic interaction between nebicapone and controlled-release levodopa/benserazide: A single-center, phase I, double-blind, randomized, placebo-controlled, four-way crossover study in healthy subjects: Original research
Nunes, Teresa, Machado, Rita, Rocha, José F, Fernandes-Lopes, Carlos, Costa, Raquel, Torrão, Leonel, Loureiro, Ana I, Falcão, Amílcar, Vaz-da-Silva, Manuel, Wright, Lyndon, Almeida, Luis, Soares-da-Silva, Patricio
Published in Clinical therapeutics (01.10.2009)
Published in Clinical therapeutics (01.10.2009)
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