Identification of Hepatitis C Virus NS5A Inhibitors
LEMM, Julie A, O'BOYLE, Donald, ROMINE, Jeffrey L, MEANWELL, Nicholas A, MIN GAO, MENGPING LIU, NOWER, Peter T, COLONNO, Richard, DESHPANDE, Milind S, SNYDER, Lawrence B, MARTIN, Scott W, LAURENT, Denis R. St, SERRANO-WU, Michael H
Published in Journal of Virology (01.01.2010)
Published in Journal of Virology (01.01.2010)
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Journal Article
effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization
Qiu, Dike, Lemm, Julie A, O’Boyle, Donald R., II, Sun, Jin-Hua, Nower, Peter T, Nguyen, Van, Hamann, Lawrence G, Snyder, Lawrence B, Deon, Daniel H, Ruediger, Edward, Meanwell, Nicholas A, Belema, Makonen, Gao, Min, Fridell, Robert A
Published in Journal of general virology (01.11.2011)
Published in Journal of general virology (01.11.2011)
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Journal Article
Discovery of Potent Hepatitis C Virus NS5A Inhibitors with Dimeric Structures
Lemm, Julie A, Leet, John E, O'Boyle, 2nd, Donald R, Romine, Jeffrey L, Huang, Xiaohua Stella, Schroeder, Daniel R, Alberts, Jeffrey, Cantone, Joseph L, Sun, Jin-Hua, Nower, Peter T, Martin, Scott W, Serrano-Wu, Michael H, Meanwell, Nicholas A, Snyder, Lawrence B, Gao, Min
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
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Journal Article
Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes
Romine, Jeffrey L, St. Laurent, Denis R, Leet, John E, Martin, Scott W, Serrano-Wu, Michael H, Yang, Fukang, Gao, Min, O’Boyle, Donald R, Lemm, Julie A, Sun, Jin-Hua, Nower, Peter T, Huang, Xiaohua (Stella), Deshpande, Milind S, Meanwell, Nicholas A, Snyder, Lawrence B
Published in ACS medicinal chemistry letters (10.03.2011)
Published in ACS medicinal chemistry letters (10.03.2011)
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Journal Article
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
Meanwell, Nicholas A, Gao, Min, Nettles, Richard E, Belema, Makonen, Snyder, Lawrence B, Nguyen, Van N, Fridell, Robert A, Serrano-Wu, Michael H, Langley, David R, Sun, Jin-Hua, O’Boyle II, Donald R, Lemm, Julie A, Wang, Chunfu, Knipe, Jay O, Chien, Caly, Colonno, Richard J, Grasela, Dennis M, Hamann, Lawrence G
Published in Nature (London) (06.05.2010)
Published in Nature (London) (06.05.2010)
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Journal Article
Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir
Belema, Makonen, Nguyen, Van N., Bachand, Carol, Deon, Dan H., Goodrich, Jason T., James, Clint A., Lavoie, Rico, Lopez, Omar D., Martel, Alain, Romine, Jeffrey L., Ruediger, Edward H., Snyder, Lawrence B., Laurent, Denis R. St, Yang, Fukang, Zhu, Juliang, Wong, Henry S., Langley, David R., Adams, Stephen P., Cantor, Glenn H., Chimalakonda, Anjaneya, Fura, Aberra, Johnson, Benjamin M., Knipe, Jay O., Parker, Dawn D., Santone, Kenneth S., Fridell, Robert A., Lemm, Julie A., O’Boyle, Donald R., Colonno, Richard J., Gao, Min, Meanwell, Nicholas A., Hamann, Lawrence G.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Identification of glutathione conjugates of acetylene-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5
Zhuo, Xiaoliang, Huang, Xiaohua Stella, Degnan, Andrew P, Snyder, Lawrence B, Yang, Fukang, Huang, Hong, Shu, Yue-Zhong, Johnson, Benjamin M
Published in Drug metabolism and disposition (01.04.2015)
Published in Drug metabolism and disposition (01.04.2015)
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Journal Article
Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box
Huang, Hong, Degnan, Andrew P., Balakrishnan, Anand, Easton, Amy, Gulianello, Michael, Huang, Yanling, Matchett, Michele, Mattson, Gail, Miller, Regina, Santone, Kenneth S., Senapati, Arun, Shields, Eric E., Sivarao, Digavalli V., Snyder, Lawrence B., Westphal, Ryan, Whiterock, Valerie J., Yang, Fukang, Bronson, Joanne J., Macor, John E.
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
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Journal Article
Characterizations of HCV NS5A replication complex inhibitors
O'Boyle II, Donald R, Sun, Jin-Hua, Nower, Peter T, Lemm, Julie A, Fridell, Robert A, Wang, Chunfu, Romine, Jeffrey L, Belema, Makonen, Nguyen, Van N, Laurent, Denis R. St, Serrano-Wu, Michael, Snyder, Lawrence B, Meanwell, Nicholas A, Langley, David R, Gao, Min
Published in Virology (New York, N.Y.) (01.09.2013)
Published in Virology (New York, N.Y.) (01.09.2013)
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Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons
Belema, Makonen, Nguyen, Van N., Romine, Jeffrey L., St. Laurent, Denis R., Lopez, Omar D., Goodrich, Jason T., Nower, Peter T., O’Boyle, Donald R., Lemm, Julie A., Fridell, Robert A., Gao, Min, Fang, Hua, Krause, Rudolph G., Wang, Ying-Kai, Oliver, A. Jayne, Good, Andrew C., Knipe, Jay O., Meanwell, Nicholas A., Snyder, Lawrence B.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies
Lopez, Omar D, Nguyen, Van N, St. Laurent, Denis R, Belema, Makonen, Serrano-Wu, Michael H, Goodrich, Jason T, Yang, Fukang, Qiu, Yuping, Ripka, Amy S, Nower, Peter T, Valera, Lourdes, Liu, Mengping, O’Boyle, Donald R., II, Sun, Jin-Hua, Fridell, Robert A, Lemm, Julie A, Gao, Min, Good, Andrew C, Meanwell, Nicholas A, Snyder, Lawrence B
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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Journal Article
Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5
Yang, Fukang, Snyder, Lawrence B, Balakrishnan, Anand, Brown, Jeffrey M, Sivarao, Digavalli V, Easton, Amy, Fernandes, Alda, Gulianello, Michael, Hanumegowda, Umesh M, Huang, Hong, Huang, Yanling, Jones, Kelli M, Li, Yu-Wen, Matchett, Michele, Mattson, Gail, Miller, Regina, Santone, Kenneth S, Senapati, Arun, Shields, Eric E, Simutis, Frank J, Westphal, Ryan, Whiterock, Valerie J, Bronson, Joanne J, Macor, John E, Degnan, Andrew P
Published in ACS medicinal chemistry letters (10.03.2016)
Published in ACS medicinal chemistry letters (10.03.2016)
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Journal Article
HCV NS5A replication complex inhibitors. Part 5: Discovery of potent and pan-genotypic glycinamide cap derivatives
Belema, Makonen, Nguyen, Van N., St. Laurent, Denis R., Lopez, Omar D., Qiu, Yuping, Good, Andrew C., Nower, Peter T., Valera, Lourdes, O’Boyle, Donald R., Sun, Jin-Hua, Liu, Mengping, Fridell, Robert A., Lemm, Julie A., Gao, Min, Knipe, Jay O., Meanwell, Nicholas A., Snyder, Lawrence B.
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
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Journal Article
HCV NS5A replication complex inhibitors. Part 2: Investigation of stilbene prolinamides
St. Laurent, Denis R., Belema, Makonen, Gao, Min, Goodrich, Jason, Kakarla, Ramesh, Knipe, Jay O., Lemm, Julie A., Liu, Mengping, Lopez, Omar D., Nguyen, Van N., Nower, Peter T., O’Boyle, Donald, Qiu, Yuping, Romine, Jeffrey L., Serrano-Wu, Michael H., Sun, Jin-Hua, Valera, Lourdes, Yang, Fukang, Yang, Xuejie, Meanwell, Nicholas A., Snyder, Lawrence B.
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
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Journal Article
HCV NS5A Replication Complex Inhibitors. Part 4. Optimization for Genotype 1a Replicon Inhibitory Activity
St. Laurent, Denis R., Serrano-Wu, Michael H., Belema, Makonen, Ding, Min, Fang, Hua, Gao, Min, Goodrich, Jason T., Krause, Rudolph G., Lemm, Julie A., Liu, Mengping, Lopez, Omar D., Nguyen, Van N., Nower, Peter T., O’Boyle, Donald R., Pearce, Bradley C., Romine, Jeffrey L., Valera, Lourdes, Sun, Jin-Hua, Wang, Ying-Kai, Yang, Fukang, Yang, Xuejie, Meanwell, Nicholas A., Snyder, Lawrence B.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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BCL6 단백질 분해의 조절제 및 관련 사용 방법
DONG HANQING, SHERMAN DAN, SNYDER LAWRENCE B, WANG JING, BERLIN MICHAEL, ZHANG WEI
Year of Publication 21.12.2023
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Year of Publication 21.12.2023
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Total Synthesis of Baccatin III and Taxol
Danishefsky, Samuel J, Masters, John J, Young, Wendy B, Link, J. T, Snyder, Lawrence B, Magee, Thomas V, Jung, David K, Isaacs, Richard C. A, Bornmann, William G, Alaimo, Cheryl A, Coburn, Craig A, Di Grandi, Martin J
Published in Journal of the American Chemical Society (27.03.1996)
Published in Journal of the American Chemical Society (27.03.1996)
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전립선암 치료 방법
SNYDER LAWRENCE B, WANG JING, HASKELL III ROYAL J, MOORE MARCIA DOUGAN, CREW ANDREW P
Year of Publication 24.06.2022
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Year of Publication 24.06.2022
Patent