Discovery of Epigenetic Regulator I‑BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains
Mirguet, Olivier, Gosmini, Romain, Toum, Jérôme, Clément, Catherine A, Barnathan, Mélanie, Brusq, Jean-Marie, Mordaunt, Jacqueline E, Grimes, Richard M, Crowe, Miriam, Pineau, Olivier, Ajakane, Myriam, Daugan, Alain, Jeffrey, Phillip, Cutler, Leanne, Haynes, Andrea C, Smithers, Nicholas N, Chung, Chun-wa, Bamborough, Paul, Uings, Iain J, Lewis, Antonia, Witherington, Jason, Parr, Nigel, Prinjha, Rab K, Nicodème, Edwige
Published in Journal of medicinal chemistry (10.10.2013)
Published in Journal of medicinal chemistry (10.10.2013)
Get full text
Journal Article
Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762
Chaidos, Aristeidis, Caputo, Valentina, Gouvedenou, Katerina, Liu, Binbin, Marigo, Ilaria, Chaudhry, Mohammed Suhail, Rotolo, Antonia, Tough, David F., Smithers, Nicholas N., Bassil, Anna K., Chapman, Trevor D., Harker, Nicola R., Barbash, Olena, Tummino, Peter, Al-Mahdi, Niam, Haynes, Andrea C., Cutler, Leanne, Le, BaoChau, Rahemtulla, Amin, Roberts, Irene, Kleijnen, Maurits, Witherington, Jason J., Parr, Nigel J., Prinjha, Rab K., Karadimitris, Anastasios
Published in Blood (30.01.2014)
Published in Blood (30.01.2014)
Get full text
Journal Article
Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin
Cruickshank, M N, Ford, J, Cheung, L C, Heng, J, Singh, S, Wells, J, Failes, T W, Arndt, G M, Smithers, N, Prinjha, R K, Anderson, D, Carter, K W, Gout, A M, Lassmann, T, O'Reilly, J, Cole, C H, Kotecha, R S, Kees, U R
Published in Leukemia (01.01.2017)
Published in Leukemia (01.01.2017)
Get full text
Journal Article
Allergenic proteases cleave the chemokine CX3CL1 directly from the surface of airway epithelium and augment the effect of rhinovirus
Loxham, M, Smart, D E, Bedke, N J, Smithers, N P, Filippi, I, Blume, C, Swindle, E J, Tariq, K, Howarth, P H, Holgate, S T, Davies, D E
Published in Mucosal immunology (01.03.2018)
Published in Mucosal immunology (01.03.2018)
Get full text
Journal Article
The HIDRALERTA system: Application to the ports of Madalena do Pico and S. Roque do Pico, Azores
Fortes, C.J.E.M., Reis, M.T., Pinheiro, L., Poseiro, P., Serrazina, V., Mendonça, A., Smithers, N., Santos, M.I., Barateiro, J., Azevedo, E.B., Salvador, M., Reis, F.V.
Published in Aquatic ecosystem health & management (01.10.2020)
Published in Aquatic ecosystem health & management (01.10.2020)
Get full text
Journal Article
A BET Protein Inhibitor Targeting Mononuclear Myeloid Cells Affects Specific Inflammatory Mediators and Pathways in Crohn’s Disease
Elfiky, Ahmed M. I, Hageman, Ishtu L, Becker, Marte A. J, Verhoeff, Jan, Li Yim, Andrew Y. F, Joustra, Vincent W, Mulders, Lieven, Fung, Ivan, Rioja, Inmaculada, Prinjha, Rab K, Smithers, Nicholas N, Furze, Rebecca C, Mander, Palwinder K, Bell, Matthew J, Buskens, Christianne J, D’Haens, Geert R, Wildenberg, Manon E, de Jonge, Wouter J
Published in Cells (Basel, Switzerland) (01.09.2022)
Published in Cells (Basel, Switzerland) (01.09.2022)
Get full text
Journal Article
B37 TELL ME WHY: COPD PATHOGENESIS: Epigenetic Changes In Hats And Hdacs Drive Pathogenesis That Can Be Reversed Using Bet Inhibitors In Experimental COPD
Jones, B, Jarnicki, A G, Smithers, N, Knight, D A, Wark, P A, Adcock, I M, Hansbro, P M
Published in American journal of respiratory and critical care medicine (01.01.2015)
Get full text
Published in American journal of respiratory and critical care medicine (01.01.2015)
Journal Article
Analysis of mutations in the putative nuclear localization sequence of interleukin-1β
GRENFELL, S, SMITHERS, N, WITHAM, S, SHAW, A, GRABER, P, SOLARI, R
Published in Biochemical journal (15.11.1991)
Published in Biochemical journal (15.11.1991)
Get full text
Journal Article
The alpha(1-3)-fucosyltransferases come of age
Edbrooke, M R, Britten, C J, Kelly, V A, Martin, S L, Smithers, N, Winder, A J, Witham, S J, Bird, M I
Published in Biochemical Society transactions (01.08.1997)
Published in Biochemical Society transactions (01.08.1997)
Get more information
Journal Article
Acceptor specificity of the human leukocyte 3 fucosyltransferase: role of FucT-VII in the generation of selectin ligands
Britten, C. J., van den Eijnden, D. H., McDowell, W., Kelly, V. A., Witham, S. J., Edbrooke, M. R., Bird, M. I., de Vries, T., Smithers, N.
Published in Glycobiology (Oxford) (01.04.1998)
Published in Glycobiology (Oxford) (01.04.1998)
Get full text
Journal Article
Investigation of guanine-nucleotide-binding protein involvement and regulation of cyclic AMP metabolism in interleukin 1 signal transduction
RAY, K, THOMPSON, N, KENNARD, N, ROLLINS, P, GRENFELL, S, WITHAM, S, SMITHERS, N, SOLARI, R
Published in Biochemical journal (15.02.1992)
Published in Biochemical journal (15.02.1992)
Get full text
Journal Article
Tissue specific expression of the human alpha(1-3) fucosyltransferase gene family
Winder, A, Smithers, N, Witham, S, Symons, A, Edbrooke, M
Published in Biochemical Society transactions (01.05.1995)
Published in Biochemical Society transactions (01.05.1995)
Get more information
Journal Article
The generation and characterisation of antagonist RNA aptamers to MCP-1
Rhodes, Andrew, Smithers, Nick, Chapman, Trevor, Parsons, Sarah, Rees, Stephen
Published in FEBS letters (05.10.2001)
Published in FEBS letters (05.10.2001)
Get full text
Journal Article