Targeting antioxidants to mitochondria by conjugation to lipophilic cations
Murphy, Michael P, Smith, Robin A J
Published in Annual review of pharmacology and toxicology (01.01.2007)
Published in Annual review of pharmacology and toxicology (01.01.2007)
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Journal Article
NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice
WALKER, Adam K, BUDAC, David P, BISULCO, Stephanie, LEE, Anna W, SMITH, Robin A, BEENDERS, Brent, KELLEY, Keith W, DANTZER, Robert
Published in Neuropsychopharmacology (New York, N.Y.) (01.08.2013)
Published in Neuropsychopharmacology (New York, N.Y.) (01.08.2013)
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Journal Article
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I
Chouchani, Edward T, Methner, Carmen, Nadtochiy, Sergiy M, Logan, Angela, Pell, Victoria R, Ding, Shujing, James, Andrew M, Cochemé, Helena M, Reinhold, Johannes, Lilley, Kathryn S, Partridge, Linda, Fearnley, Ian M, Robinson, Alan J, Hartley, Richard C, Smith, Robin A J, Krieg, Thomas, Brookes, Paul S, Murphy, Michael P
Published in Nature medicine (01.06.2013)
Published in Nature medicine (01.06.2013)
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Journal Article
Animal and human studies with the mitochondria-targeted antioxidant MitoQ
Smith, Robin A.J., Murphy, Michael P.
Published in Annals of the New York Academy of Sciences (01.07.2010)
Published in Annals of the New York Academy of Sciences (01.07.2010)
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Journal Article
A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease
Snow, Barry J., Rolfe, Fiona L., Lockhart, Michelle M., Frampton, Christopher M., O'Sullivan, John D., Fung, Victor, Smith, Robin A.J., Murphy, Michael P., Taylor, Kenneth M.
Published in Movement disorders (15.08.2010)
Published in Movement disorders (15.08.2010)
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Journal Article
The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients
Gane, Edward J., Weilert, Frank, Orr, David W., Keogh, Geraldine F., Gibson, Michael, Lockhart, Michelle M., Frampton, Christopher M., Taylor, Kenneth M., Smith, Robin A. J., Murphy, Michael P.
Published in Liver international (01.08.2010)
Published in Liver international (01.08.2010)
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Journal Article
Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila
Cochemé, Helena M, Logan, Angela, Prime, Tracy A, Abakumova, Irina, Quin, Caroline, McQuaker, Stephen J, Patel, Jigna V, Fearnley, Ian M, James, Andrew M, Porteous, Carolyn M, Smith, Robin A J, Hartley, Richard C, Partridge, Linda, Murphy, Michael P
Published in Nature protocols (19.04.2012)
Published in Nature protocols (19.04.2012)
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Journal Article
Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells
Ross, Meredith F, Prime, Tracy A, Abakumova, Irina, James, Andrew M, Porteous, Carolyn M, Smith, Robin A J, Murphy, Michael P
Published in Biochemical journal (01.05.2008)
Published in Biochemical journal (01.05.2008)
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Journal Article
Characteristics of memory B cells elicited by a highly efficacious HPV vaccine in subjects with no pre-existing immunity
Scherer, Erin M, Smith, Robin A, Simonich, Cassandra A, Niyonzima, Nixon, Carter, Joseph J, Galloway, Denise A
Published in PLoS pathogens (01.10.2014)
Published in PLoS pathogens (01.10.2014)
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Journal Article
Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus
Brooks, Alexandra K, Lawson, Marcus A, Smith, Robin A, Janda, Tiffany M, Kelley, Keith W, McCusker, Robert H
Published in Journal of neuroinflammation (03.05.2016)
Published in Journal of neuroinflammation (03.05.2016)
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Journal Article
Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation
Chouchani, Edward T, Hurd, Thomas R, Nadtochiy, Sergiy M, Brookes, Paul S, Fearnley, Ian M, Lilley, Kathryn S, Smith, Robin A J, Murphy, Michael P
Published in Biochemical journal (15.08.2010)
Published in Biochemical journal (15.08.2010)
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Journal Article
Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis
Miquel, Ernesto, Cassina, Adriana, Martínez-Palma, Laura, Souza, José M., Bolatto, Carmen, Rodríguez-Bottero, Sebastián, Logan, Angela, Smith, Robin A.J., Murphy, Michael P., Barbeito, Luis, Radi, Rafael, Cassina, Patricia
Published in Free radical biology & medicine (01.05.2014)
Published in Free radical biology & medicine (01.05.2014)
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Journal Article
Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G
Methner, Carmen, Lukowski, Robert, Grube, Karina, Loga, Florian, Smith, Robin A. J., Murphy, Michael P., Hofmann, Franz, Krieg, Thomas
Published in Basic research in cardiology (01.03.2013)
Published in Basic research in cardiology (01.03.2013)
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Journal Article
Resolution of Mitochondrial Oxidative Stress Rescues Coronary Collateral Growth in Zucker Obese Fatty Rats
Pung, Yuh Fen, Rocic, Petra, Murphy, Michael P, Smith, Robin A.J, Hafemeister, Jennifer, Ohanyan, Vahagn, Guarini, Giacinta, Yin, Liya, Chilian, William M
Published in Arteriosclerosis, thrombosis, and vascular biology (01.02.2012)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.02.2012)
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Journal Article
Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism
Mourtada, Rida, Fonseca, Sonali B, Wisnovsky, Simon P, Pereira, Mark P, Wang, Xiaoming, Hurren, Rose, Parfitt, Jeremy, Larsen, Lesley, Smith, Robin A J, Murphy, Michael P, Schimmer, Aaron D, Kelley, Shana O
Published in PloS one (09.04.2013)
Published in PloS one (09.04.2013)
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Journal Article
Assessing the Delivery of Molecules to the Mitochondrial Matrix Using Click Chemistry
Hoogewijs, Kurt, James, Andrew M., Smith, Robin A. J., Gait, Michael J., Murphy, Michael P., Lightowlers, Robert N.
Published in Chembiochem : a European journal of chemical biology (15.07.2016)
Published in Chembiochem : a European journal of chemical biology (15.07.2016)
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Journal Article
Direct Modification of the Proinflammatory Cytokine Macrophage Migration Inhibitory Factor by Dietary Isothiocyanates
Brown, Kristin K., Blaikie, Frances H., Smith, Robin A.J., Tyndall, Joel D.A., Lue, Hongqi, Bernhagen, Jürgen, Winterbourn, Christine C., Hampton, Mark B.
Published in The Journal of biological chemistry (20.11.2009)
Published in The Journal of biological chemistry (20.11.2009)
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Journal Article
Delivery of Bioactive Molecules to Mitochondria in vivo
Robin A. J. Smith, Porteous, Carolyn M., Gane, Alison M., Murphy, Michael P.
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.2003)
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Journal Article
mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury
Prime, Tracy A, Blaikie, Frances H, Evans, Cameron, Nadtochiy, Sergiy M, James, Andrew M, Dahm, Christina C, Vitturi, Dario A, Patel, Rakesh P, Hiley, C. Robin, Abakumova, Irina, Requejo, Raquel, Chouchani, Edward T, Hurd, Thomas R, Garvey, John F, Taylor, Cormac T, Brookes, Paul S, Smith, Robin A.J, Murphy, Michael P
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2009)
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