The giant protein titin regulates the length of the striated muscle thick filament
Tonino, Paola, Kiss, Balazs, Strom, Josh, Methawasin, Mei, Smith, 3rd, John E, Kolb, Justin, Labeit, Siegfried, Granzier, Henk
Published in Nature communications (19.10.2017)
Published in Nature communications (19.10.2017)
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Journal Article
Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole
Methawasin, Mei, Hutchinson, Kirk R, Lee, Eun-Jeong, Smith, John E, Saripalli, Chandra, Hidalgo, Carlos G, Ottenheijm, Coen A.C, Granzier, Henk
Published in Circulation (New York, N.Y.) (13.05.2014)
Published in Circulation (New York, N.Y.) (13.05.2014)
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Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function
Granzier, Henk L., Hutchinson, Kirk R., Tonino, Paola, Methawasin, Mei, Li, Frank W., Slater, Rebecca E., Bull, Mathew M., Saripalli, Chandra, Pappas, Christopher T., Gregorio, Carol C., Smith, John E.
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2014)
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Journal Article
Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism
Lindqvist, Johan, Ma, Weikang, Li, Frank, Hernandez, Yaeren, Kolb, Justin, Kiss, Balazs, Tonino, Paola, van der Pijl, Robbert, Karimi, Esmat, Gong, Henry, Strom, Josh, Hourani, Zaynab, Smith, 3rd, John E, Ottenheijm, Coen, Irving, Thomas, Granzier, Henk
Published in Nature communications (01.06.2020)
Published in Nature communications (01.06.2020)
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Journal Article
Phosphorylating Titin’s Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force
Perkin, John, Slater, Rebecca, Del Favero, Giorgia, Lanzicher, Thomas, Hidalgo, Carlos, Anderson, Brian, Smith, John E., Sbaizero, Orfeo, Labeit, Siegfried, Granzier, Henk
Published in Biophysical journal (15.12.2015)
Published in Biophysical journal (15.12.2015)
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Journal Article
Shortening of the Elastic Tandem Immunoglobulin Segment of Titin Leads to Diastolic Dysfunction
Chung, Charles S, Hutchinson, Kirk R, Methawasin, Mei, Saripalli, Chandra, Smith, John E, Hidalgo, Carlos G, Luo, Xiuju, Labeit, Siegfried, Guo, Caiying, Granzier, Henk L
Published in Circulation (New York, N.Y.) (02.07.2013)
Published in Circulation (New York, N.Y.) (02.07.2013)
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Journal Article
Phosphodiesterase 9a Inhibition in Mouse Models of Diastolic Dysfunction
Methawasin, Mei, Strom, Joshua, Borkowski, Tomasz, Hourani, Zaynab, Runyan, Ray, Smith, 3rd, John E, Granzier, Henk
Published in Circulation. Heart failure (01.05.2020)
Published in Circulation. Heart failure (01.05.2020)
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Journal Article
Shortening the thick filament by partial deletion of titin's C-zone alters cardiac function by reducing the operating sarcomere length range
Methawasin, Mei, Farman, Gerrie P., Granzier-Nakajima, Shawtaroh, Strom, Joshua, Kiss, Balazs, Smith, John E., Granzier, Henk
Published in Journal of molecular and cellular cardiology (01.04.2022)
Published in Journal of molecular and cellular cardiology (01.04.2022)
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Single-Molecule Force Spectroscopy on the N2A Element of Titin: Effects of Phosphorylation and CARP
Lanzicher, Thomas, Zhou, Tiankun, Saripalli, Chandra, Keschrumrus, Vic, Smith Iii, John E, Mayans, Olga, Sbaizero, Orfeo, Granzier, Henk
Published in Frontiers in physiology (18.03.2020)
Published in Frontiers in physiology (18.03.2020)
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Journal Article
Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy
Buck, Danielle, Smith, 3rd, John E, Chung, Charles S, Ono, Yasuko, Sorimachi, Hiroyuki, Labeit, Siegfried, Granzier, Henk L
Published in The Journal of general physiology (01.02.2014)
Published in The Journal of general physiology (01.02.2014)
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Journal Article
Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy
Li, Frank, Buck, Danielle, De Winter, Josine, Kolb, Justin, Meng, Hui, Birch, Camille, Slater, Rebecca, Escobar, Yael Natelie, Smith, 3rd, John E, Yang, Lin, Konhilas, John, Lawlor, Michael W, Ottenheijm, Coen, Granzier, Henk L
Published in Human molecular genetics (15.09.2015)
Published in Human molecular genetics (15.09.2015)
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Journal Article
Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: effects on muscle structure and function
Li, Frank, Kolb, Justin, Crudele, Julie, Tonino, Paola, Hourani, Zaynab, Smith, 3rd, John E, Chamberlain, Jeffrey S, Granzier, Henk
Published in Skeletal muscle (28.01.2020)
Published in Skeletal muscle (28.01.2020)
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Journal Article
Correction to: Expressing a Z-disk nebulin fragment innebulin-deficient mouse muscle: effects on muscle structure and function
Li, Frank, Kolb, Justin, Crudele, Julie, Tonino, Paola, Hourani, Zaynab, Smith, 3rd, John E, Chamberlain, Jeffrey S, Granzier, Henk
Published in Skeletal muscle (20.04.2020)
Published in Skeletal muscle (20.04.2020)
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Journal Article
Nebulin and Lmod2 are critical for specifying thin-filament length in skeletal muscle
Kiss, Balázs, Gohlke, Jochen, Tonino, Paola, Hourani, Zaynab, Kolb, Justin, Strom, Joshua, Alekhina, Olga, Smith, 3rd, John E, Ottenheijm, Coen, Gregorio, Carol, Granzier, Henk
Published in Science advances (01.11.2020)
Published in Science advances (01.11.2020)
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ZFH-2 is required for Drosophila ovarian follicle development and is expressed at the band/interband boundaries of polytene chromosomes
Guntur, Ananya R., Smith, John E., Brahmandam, Archana, DeBauche, Phillip, Cronmiller, Claire, Lundell, Martha J.
Published in Developmental biology (01.12.2023)
Published in Developmental biology (01.12.2023)
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