Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors
Hoegenauer, Klemens, Soldermann, Nicolas, Zécri, Frédéric, Strang, Ross S, Graveleau, Nadege, Wolf, Romain M, Cooke, Nigel G, Smith, Alexander B, Hollingworth, Gregory J, Blanz, Joachim, Gutmann, Sascha, Rummel, Gabriele, Littlewood-Evans, Amanda, Burkhart, Christoph
Published in ACS medicinal chemistry letters (14.09.2017)
Published in ACS medicinal chemistry letters (14.09.2017)
Get full text
Journal Article
Liberation of host heme by Clostridioides difficile- mediated damage enhances Enterococcus faecalis fitness during infection
Smith, Alexander B, Specker, Jonathan T, Hewlett, Katharine K, Scoggins, 4th, Troy R, Knight, Montana, Lustig, Abigail M, Li, Yanhong, Evans, Kirsten M, Guo, Yingchan, She, Qianxuan, Christopher, Michael W, Garrett, Timothy J, Moustafa, Ahmed M, Van Tyne, Daria, Prentice, Boone M, Zackular, Joseph P
Published in mBio (16.01.2024)
Published in mBio (16.01.2024)
Get full text
Journal Article
Discovery and Profiling of a Selective and Efficacious Syk Inhibitor
Thoma, Gebhard, Smith, Alexander B, van Eis, Maurice J, Vangrevelinghe, Eric, Blanz, Joachim, Aichholz, Reiner, Littlewood-Evans, Amanda, Lee, Christian C, Liu, Hong, Zerwes, Hans-Günter
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
Get full text
Journal Article
Enterococci enhance Clostridioides difficile pathogenesis
Smith, Alexander B, Jenior, Matthew L, Keenan, Orlaith, Hart, Jessica L, Specker, Jonathan, Abbas, Arwa, Rangel, Paula C, Di, Chao, Green, Jamal, Bustin, Katelyn A, Gaddy, Jennifer A, Nicholson, Maribeth R, Laut, Clare, Kelly, Brendan J, Matthews, Megan L, Evans, Daniel R, Van Tyne, Daria, Furth, Emma E, Papin, Jason A, Bushman, Frederic D, Erlichman, Jessi, Baldassano, Robert N, Silverman, Michael A, Dunny, Gary M, Prentice, Boone M, Skaar, Eric P, Zackular, Joseph P
Published in Nature (London) (24.11.2022)
Published in Nature (London) (24.11.2022)
Get full text
Journal Article
From Nursery to Nursing Home: Emerging Concepts in Clostridioides difficile Pathogenesis
Smith, Alexander B, Soto Ocana, Joshua, Zackular, Joseph P
Published in Infection and immunity (22.06.2020)
Published in Infection and immunity (22.06.2020)
Get full text
Journal Article
Three-dimensional airflow and sediment transport patterns over barchan dunes
Smith, Alexander B., Jackson, Derek W.T., Cooper, J. Andrew G.
Published in Geomorphology (Amsterdam, Netherlands) (01.02.2017)
Published in Geomorphology (Amsterdam, Netherlands) (01.02.2017)
Get full text
Journal Article
Design and Synthesis of trans-3-(2-(4-((3-(3-(5-Methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro- 1H-3-benzazepine (SB-414796): A Potent and Selective Dopamine D3 Receptor Antagonist
Macdonald, Gregor J, Branch, Clive L, Hadley, Michael S, Johnson, Christopher N, Nash, David J, Smith, Alexander B, Stemp, Geoffrey, Thewlis, Kevin M, Vong, Antonio K. K, Austin, Nigel E, Jeffrey, Phillip, Winborn, Kim Y, Boyfield, Izzy, Hagan, Jim J, Middlemiss, Derek N, Reavill, Charlie, Riley, Graham J, Watson, Jeannette M, Wood, Martyn, Parker, Steve G, Ashby, Charles R
Published in Journal of medicinal chemistry (06.11.2003)
Published in Journal of medicinal chemistry (06.11.2003)
Get full text
Journal Article
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
Specker, Jonathan T, Smith, Alexander B, Keenan, Orlaith, Zackular, Joseph P, Prentice, Boone M
Published in Journal of visualized experiments (18.11.2022)
Published in Journal of visualized experiments (18.11.2022)
Get more information
Journal Article
Discovery of novel pyrrolidineoxy-substituted heteroaromatics as potent and selective PI3K delta inhibitors with improved physicochemical properties
Hoegenauer, Klemens, Soldermann, Nicolas, Hebach, Christina, Hollingworth, Gregory J., Lewis, Ian, von Matt, Anette, Smith, Alexander B., Wolf, Romain M., Wilcken, Rainer, Haasen, Dorothea, Burkhart, Christoph, Zécri, Frédéric
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
Get full text
Journal Article
Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors
Hoegenauer, Klemens, Soldermann, Nicolas, Stauffer, Frédéric, Furet, Pascal, Graveleau, Nadege, Smith, Alexander B, Hebach, Christina, Hollingworth, Gregory J, Lewis, Ian, Gutmann, Sascha, Rummel, Gabriele, Knapp, Mark, Wolf, Romain M, Blanz, Joachim, Feifel, Roland, Burkhart, Christoph, Zécri, Frédéric
Published in ACS medicinal chemistry letters (11.08.2016)
Published in ACS medicinal chemistry letters (11.08.2016)
Get full text
Journal Article
Quantifying the role of urbanization on airflow perturbations and dunefield evolution
Smith, Alexander B., Jackson, Derek W. T., Cooper, J. Andrew G., Hernández‐Calvento, L.
Published in Earth's future (01.05.2017)
Published in Earth's future (01.05.2017)
Get full text
Journal Article
Syk inhibitors with high potency in presence of blood
Thoma, Gebhard, Blanz, Joachim, Bühlmayer, Peter, Drückes, Peter, Kittelmann, Matthias, Smith, Alexander B., van Eis, Maurice, Vangrevelinghe, Eric, Zerwes, Hans-Günter, Che, Jianwei (John), He, Xiaohui, Jin, Yunho, Lee, Christian C., Michellys, Pierre-Yves, Uno, Tetsuo, Liu, Hong
Published in Bioorganic & medicinal chemistry letters (15.05.2014)
Published in Bioorganic & medicinal chemistry letters (15.05.2014)
Get full text
Journal Article
Event‐Scale Dynamics of a Parabolic Dune and Its Relevance for Mesoscale Evolution
Delgado‐Fernandez, Irene, Smyth, Thomas A. G., Jackson, Derek W. T., Smith, Alexander B., Davidson‐Arnott, Robin G. D.
Published in Journal of geophysical research. Earth surface (01.11.2018)
Published in Journal of geophysical research. Earth surface (01.11.2018)
Get full text
Journal Article
Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment
Chen, Po-Han, Hu, Jimin, Wu, Jianli, Huynh, Duc T, Smith, Timothy J, Pan, Samuel, Bisnett, Brittany J, Smith, Alexander B, Lu, Annie, Condon, Brett M, Chi, Jen-Tsan, Boyce, Michael
Published in JCI insight (16.01.2020)
Published in JCI insight (16.01.2020)
Get full text
Journal Article
Studies towards the identification of a new generation of atypical antipsychotic agents
Garzya, Vincenzo, Forbes, Ian T., Gribble, Andrew D., Hadley, Mike S., Lightfoot, Andrew P., Payne, Andrew H., Smith, Alexander B., Douglas, Sara E., Cooper, David G., Stansfield, Ian G., Meeson, Malcom, Dodds, Emma E., Jones, Declan N.C., Wood, Martyn, Reavill, Charlie, Scorer, Carol A., Worby, Angela, Riley, Graham, Eddershaw, Peter, Ioannou, Chris, Donati, Daniele, Hagan, Jim J., Ratti, Emiliangelo A.
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
Get full text
Journal Article
SnB version 2.3: triplet sieve phasing for centrosymmetric structures
Xu, Hongliang, Smith, Alexander B., Sahinidis, Nikolaos V., Weeks, Charles M.
Published in Journal of applied crystallography (01.06.2008)
Published in Journal of applied crystallography (01.06.2008)
Get full text
Journal Article