Search Results - "SMILJANIC, ELA" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

by Baker, David A, Stewart, Lindsay B, Large, Jonathan M, Bowyer, Paul W, Ansell, Keith H, Jiménez-Díaz, María B, El Bakkouri, Majida, Birchall, Kristian, Dechering, Koen J, Bouloc, Nathalie S, Coombs, Peter J, Whalley, David, Harding, Denise J, Smiljanic-Hurley, Ela, Wheldon, Mary C, Walker, Eloise M, Dessens, Johannes T, Lafuente, María José, Sanz, Laura M, Gamo, Francisco-Javier, Ferrer, Santiago B, Hui, Raymond, Bousema, Teun, Angulo-Barturén, Iñigo, Merritt, Andy T, Croft, Simon L, Gutteridge, Winston E, Kettleborough, Catherine A, Osborne, Simon A
Published in Nature communications (05.09.2017)

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Journal Article

Monocyclic β-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases

Monocyclic β-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases

by Pierrat, Olivier A, Strisovsky, Kvido, Christova, Yonka, Large, Jonathan, Ansell, Keith, Bouloc, Nathalie, Smiljanic, Ela, Freeman, Matthew
Published in ACS chemical biology (15.04.2011)

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Journal Article

Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7

Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7

by Bouloc, Nathalie, Large, Jonathan M., Smiljanic, Ela, Whalley, David, Ansell, Keith H., Edlin, Christopher D., Bryans, Justin S.
Published in Bioorganic & medicinal chemistry (01.10.2008)

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Journal Article

COMPOUNDS

COMPOUNDS

by MCIVER EDWARD GILES, HARDING DENISE JAMILLA, SMILJANIC ELA, HOUGH JOANNE
Year of Publication 30.11.2011

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Patent

Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2) – Part 1

Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2) – Part 1

by Osborne, Joanne, Birchall, Kristian, Tsagris, Denise J., Lewis, Stephen J., Smiljanic-Hurley, Ela, Taylor, Debra L., Levy, Alison, Alessi, Dario R., McIver, Edward G.
Published in Bioorganic & medicinal chemistry letters (15.02.2019)

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Journal Article

Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG)

Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG)

by Tsagris, Denise J., Birchall, Kristian, Bouloc, Nathalie, Large, Jonathan M., Merritt, Andy, Smiljanic-Hurley, Ela, Wheldon, Mary, Ansell, Keith H., Kettleborough, Catherine, Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Published in Bioorganic & medicinal chemistry letters (15.10.2018)

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Journal Article

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty

by Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Published in Bioorganic & medicinal chemistry letters (01.10.2019)

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Journal Article

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines

by Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Published in Bioorganic & medicinal chemistry letters (01.02.2019)

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Journal Article

Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1

Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1

by Ansell, Keith H, Jones, Hayley M, Whalley, David, Hearn, Alisdair, Taylor, Debra L, Patin, Emmanuel C, Chapman, Timothy M, Osborne, Simon A, Wallace, Claire, Birchall, Kristian, Large, Jonathan, Bouloc, Nathalie, Smiljanic-Hurley, Ela, Clough, Barbara, Moon, Robert W, Green, Judith L, Holder, Anthony A
Published in Antimicrobial agents and chemotherapy (01.10.2014)

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Journal Article

Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues

Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues

by Large, Jonathan M., Osborne, Simon A., Smiljanic-Hurley, Ela, Ansell, Keith H., Jones, Hayley M., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Published in Bioorganic & medicinal chemistry letters (01.11.2013)

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Journal Article

Synthesis and structure–activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

Synthesis and structure–activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

by McIver, Edward G., Bryans, Justin, Birchall, Kristian, Chugh, Jasveen, Drake, Thomas, Lewis, Stephen J., Osborne, Joanne, Smiljanic-Hurley, Ela, Tsang, William, Kamal, Ahmad, Levy, Alison, Newman, Michelle, Taylor, Debra, Arthur, J. Simon C., Clark, Kristopher, Cohen, Philip
Published in Bioorganic & medicinal chemistry letters (01.12.2012)

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Journal Article

PYRAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS LRRK2 INHIBITORS

PYRAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS LRRK2 INHIBITORS

by HARDING, DENISE JAMILLA, MCIVER, EDWARD GILES, HOUGH, JOANNE, SMILJANIC, ELA
Year of Publication 17.04.2018

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Patent

COMPOUNDS

COMPOUNDS

by HARDING Denise Jamilla, SMILJANIC Ela, HOUGH Joanne, MCIVER Edward Giles
Year of Publication 09.11.2017

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Patent

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKK[e] kinases

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKK[e] kinases

by McIver, Edward G, Bryans, Justin, Birchall, Kristian, Chugh, Jasveen, Drake, Thomas, Lewis, Stephen J, Osborne, Joanne, Smiljanic-Hurley, Ela, Tsang, William, Kamal, Ahmad, Levy, Alison, Newman, Michelle, Taylor, Debra, Arthur, JSimon C, Clark, Kristopher, Cohen, Philip
Published in Bioorganic & medicinal chemistry letters (01.12.2012)

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Journal Article

Compounds

Compounds

by HARDING, DENISE JAMILLA, MCIVER, EDWARD GILES, HOUGH, JOANNE, SMILJANIC, ELA
Year of Publication 28.07.2016

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Patent

COMPOUNDS

COMPOUNDS

by HARDING, DENISE, JAMILLA, HOUGH, JOANNE, MCIVER, EDWARD, GILES, SMILJANIC, ELA
Year of Publication 01.07.2015

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Patent

Corrigendum to “Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues” [Bioorg. Med. Chem. Lett. 23 (2013) 6019–6024]

Corrigendum to “Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues” [Bioorg. Med. Chem. Lett. 23 (2013) 6019–6024]

by Large, Jonathan M., Osborne, Simon A., Smiljanic-Hurley, Ela, Ansell, Keith H., Jones, Hayley M., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Published in Bioorganic & medicinal chemistry letters (01.01.2014)

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Journal Article

DERIVADOS DE PIRAZOLOPIRIDINA COMO INHIBIDORES DE QUINASAS

DERIVADOS DE PIRAZOLOPIRIDINA COMO INHIBIDORES DE QUINASAS

by HARDING, DENISE JAMILLA, MCIVER, EDWARD GILES, HOUGH, JOANNE, SMILJANIC, ELA
Year of Publication 14.05.2012

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Patent

COMPOUNDS

COMPOUNDS

by HARDING, DENISE, JAMILLA, HOUGH, JOANNE, MCIVER, EDWARD, GILES, SMILJANIC, ELA
Year of Publication 25.01.2012

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Patent

Compounds

Compounds

by HARDING, DENISE JAMILLA, MCIVER, EDWARD GILES, HOUGH, JOANNE, SMILJANIC, ELA
Year of Publication 15.09.2011

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Patent