Factor XIa Inhibitors as New Anticoagulants
Quan, Mimi L, Pinto, Donald J. P, Smallheer, Joanne M, Ewing, William R, Rossi, Karen A, Luettgen, Joseph M, Seiffert, Dietmar A, Wexler, Ruth R
Published in Journal of medicinal chemistry (13.09.2018)
Published in Journal of medicinal chemistry (13.09.2018)
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Journal Article
Factor Xa Inhibitors: Next-Generation Antithrombotic Agents
Pinto, Donald J. P, Smallheer, Joanne M, Cheney, Daniel L, Knabb, Robert M, Wexler, Ruth R
Published in Journal of medicinal chemistry (09.09.2010)
Published in Journal of medicinal chemistry (09.09.2010)
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Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO)
Hu, Carol H., Neissel Valente, Meriah W., Halpern, O. Scott, Jusuf, Sutjano, Khan, Javed A., Locke, Gregory A., Duke, Gerald J., Liu, Xiaoqin, Duclos, Franck J., Wexler, Ruth R., Kick, Ellen K., Smallheer, Joanne M.
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
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Tetrahydroquinoline Derivatives as Potent and Selective Factor XIa Inhibitors
Quan, Mimi L, Wong, Pancras C, Wang, Cailan, Woerner, Francis, Smallheer, Joanne M, Barbera, Frank A, Bozarth, Jeffrey M, Brown, Randi L, Harpel, Mark R, Luettgen, Joseph M, Morin, Paul E, Peterson, Tara, Ramamurthy, Vidhyashankar, Rendina, Alan R, Rossi, Karen A, Watson, Carol A, Wei, Anzhi, Zhang, Ge, Seiffert, Dietmar, Wexler, Ruth R
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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Journal Article
Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability
Clark, Charles G., Rossi, Karen A., Corte, James R., Fang, Tianan, Smallheer, Joanne M., De Lucca, Indawati, Nirschl, David S., Orwat, Michael J., Pinto, Donald J.P., Hu, Zilun, Wang, Yufeng, Yang, Wu, Jeon, Yoon, Ewing, William R., Myers, Joseph E., Sheriff, Steven, Lou, Zhen, Bozarth, Jeffrey M., Wu, Yiming, Rendina, Alan, Harper, Timothy, Zheng, Joanna, Xin, Baomin, Xiang, Qian, Luettgen, Joseph M., Seiffert, Dietmar A., Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (01.10.2019)
Published in Bioorganic & medicinal chemistry letters (01.10.2019)
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Journal Article
Phenylimidazoles as Potent and Selective Inhibitors of Coagulation Factor XIa with in Vivo Antithrombotic Activity
Hangeland, Jon J, Friends, Todd J, Rossi, Karen A, Smallheer, Joanne M, Wang, Cailan, Sun, Zhong, Corte, James R, Fang, Tianan, Wong, Pancras C, Rendina, Alan R, Barbera, Frank A, Bozarth, Jeffrey M, Luettgen, Joseph M, Watson, Carol A, Zhang, Ge, Wei, Anzhi, Ramamurthy, Vidhyashankar, Morin, Paul E, Bisacchi, Gregory S, Subramaniam, Srinath, Arunachalam, Piramanayagam, Mathur, Arvind, Seiffert, Dietmar A, Wexler, Ruth R, Quan, Mimi L
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Journal Article
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties
Pinto, Donald J.P., Smallheer, Joanne M., Corte, James R., Austin, Erin J.D., Wang, Cailan, Fang, Tianan, Smith, Leon M., Rossi, Karen A., Rendina, Alan R., Bozarth, Jeffrey M., Zhang, Ge, Wei, Anzhi, Ramamurthy, Vidhyashankar, Sheriff, Steven, Myers, Joseph E., Morin, Paul E., Luettgen, Joseph M., Seiffert, Dietmar A., Quan, Mimi L., Wexler, Ruth R.
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
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Journal Article
Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues
Qiao, Jennifer X., Cheng, Xuhong, Smallheer, Joanne M., Galemmo, Robert A., Drummond, Spencer, Pinto, Donald J.P., Cheney, Daniel L., He, Kan, Wong, Pancras C., Luettgen, Joseph M., Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
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Journal Article
SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa
SMALLHEER, Joanne M, ALEXANDER, Richard S, KNABB, Robert M, WEXLER, Ruth R, JADHAV, Prabhakar K, JIANMIN WANG, SHUAIGE WANG, NAKAJIMA, Suanne, ROSSI, Karen A, SMALLWOOD, Angela, BARBERA, Frank, BURDICK, Debra, LUETTGEN, Joseph M
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
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Sulfonamidolactam inhibitors of coagulation factor Xa
Smallheer, Joanne M., Wang, Shuaige, Laws, Mia L., Nakajima, Suanne, Hu, Zilun, Han, Wei, Jacobson, Irina, Luettgen, Joseph M., Rossi, Karen A., Rendina, Alan R., Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S., Quan, Mimi L.
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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Synthesis and biological evaluation of nonpeptide integrin antagonists containing spirocyclic scaffolds
Smallheer, Joanne M., Weigelt, Carolyn A., Woerner, Francis J., Wells, Jennifer S., Daneker, Wayne F., Mousa, Shaker A., Wexler, Ruth R., Jadhav, Prabhakar K.
Published in Bioorganic & medicinal chemistry letters (19.01.2004)
Published in Bioorganic & medicinal chemistry letters (19.01.2004)
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Total Synthesis of (.+-.)-Dragmacidin: A Cytotoxic Bis(indole)alkaloid of Marine Origin
Jiang, Biao, Smallheer, Joanne M, Amaral-Ly, Carol, Wuonola, Mark A
Published in Journal of organic chemistry (01.11.1994)
Published in Journal of organic chemistry (01.11.1994)
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Isoxazolines as Potent Antagonists of the Integrin αvβ3
Pitts, William J, Wityak, John, Smallheer, Joanne M, Tobin, A. Ewa, Jetter, James W, Buynitsky, Jennifer S, Harlow, Patricia P, Solomon, Kimberly A, Corjay, Martha H, Mousa, Shaker A, Wexler, Ruth R, Jadhav, Prabhakar K
Published in Journal of medicinal chemistry (13.01.2000)
Published in Journal of medicinal chemistry (13.01.2000)
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피라졸론 포르밀 펩티드 2 수용체 효능제
VALENTE MERIAH NEISSEL, KICK ELLEN K, SHIRUDE PRAVIN SUDHAKAR, JOHNSON JAMES A, SMALLHEER JOANNE M, WURTZ NICHOLAS R, CLARK CHARLES G, PI ZULAN, SESHADRI BALAJI, CHATTOPADHYAY AMIT KUMAR
Year of Publication 20.03.2023
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Year of Publication 20.03.2023
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The race to an orally active Factor Xa inhibitor: recent advances
Quan, Mimi L, Smallheer, Joanne M
Published in Current opinion in drug discovery & development (01.07.2004)
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Published in Current opinion in drug discovery & development (01.07.2004)
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시클로프로필 우레아 포르밀 펩티드 2 수용체 및 포르밀 펩티드 1 수용체 효능제
VALENTE MERIAH NEISSEL, KICK ELLEN K, SMALLHEER JOANNE M, WURTZ NICHOLAS R, ROSSI KAREN A
Year of Publication 13.02.2020
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Year of Publication 13.02.2020
Patent
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties
Pinto, Donald J. P., Smallheer, Joanne M., Corte, James R., Austin, Erin J. D., Wang, Cailan, Fang, Tianan, Smith, II, Leon M., Rossi, Karen A., Rendina, Alan R., Bozarth, Jeffrey M., Zhang, Ge, Wei, Anzhi, Ramamurthy, Vidhyashankar, Sheriff, Steven, Myers, Jr., Joseph E., Morin, Paul E., Luettgen, Joseph M., Seiffert, Dietmar A., Quan, Mimi L., Wexler, Ruth R.
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
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Published in Bioorganic & medicinal chemistry letters (01.04.2015)
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미엘로퍼옥시다제의 마크로시클릭 억제제
KICK ELLEN K, VALENTE MERIAH NEISSEL, HALPERN OZ SCOTT, SMALLHEER JOANNE M, HU CAROL HUI, JUSUF SUTJANO
Year of Publication 06.03.2019
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Year of Publication 06.03.2019
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A nonpetide integrin antagonist can inhibit epithelial cell ingestion of Streptococcus pyogenes by blocking formation of integrin α5β1-fibronectin-M1 protein complexes
Cue, David, Southern, Sarka O., Southern, Peter J., Prabhakar, Jadhar, Lorelli, William, Smallheer, Joanne M., Mousa, Shaker A., Cleary, P. Patrick
Published in Proceedings of the National Academy of Sciences - PNAS (14.03.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (14.03.2000)
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