BMS-201620: a selective beta 3 agonist
Washburn, W.N., Sun, C.-Q., Bisacchi, G., Wu, G., Cheng, P.T., Sher, P.M., Ryono, D., Gavai, A.V., Poss, K., Girotra, R.N., McCann, P.J., Mikkilineni, A.B., Dejneka, T.C., Wang, T.C., Merchant, Z., Morella, M., Arbeeny, C.M., Harper, T.W., Slusarchyk, D.A., Skwish, S., Russell, A.D., Allen, G.T., Tesfamariam, B., Frohlich, B.H., Abboa-Offei, B.E., Cap, M., Waldron, T.L., George, R.J., Young, D., Dickinson, K.E., Seymour, A.A.
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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Beta 3 agonists. Part 1: evolution from inception to BMS-194449
Washburn, W.N., Sher, P.M., Poss, K.M., Girotra, R.N., McCann, P.J., Gavai, A.V., Mikkilineni, A.B., Mathur, A., Cheng, P., Dejneka, T.C., Sun, C.Q., Wang, T.C., Harper, T.W., Russell, A.D., Slusarchyk, D.A., Skwish, S., Allen, G.T., Hillyer, D.E., Frohlich, B.H., Abboa-Offei, B.E., Cap, M., Waldron, T.L., George, R.J., Tesfamariam, B., Ciosek, C.P., Ryono, D., Young, D.A., Dickinson, K.E., Seymour, A.A., Arbeeny, C.M., Gregg, R.E.
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
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Journal Article
α-Phosphonosulfonic Acids: Potent and Selective Inhibitors of Squalene Synthase
Magnin, David R, Biller, Scott A, Chen, Ying, Dickson, John K, Fryszman, Olga M, Lawrence, R. Michael, Logan, Janette V. H, Sieber-McMaster, Ellen S, Sulsky, Richard B, Traeger, Sarah C, Hsieh, Dolly C, Lan, Shih-Jung, Rinehart, J. Kent, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Rich, Lois C, Slusarchyk, Dorothy A, Ciosek, Carl P
Published in Journal of medicinal chemistry (02.02.1996)
Published in Journal of medicinal chemistry (02.02.1996)
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Journal Article
Arylpropanolamines : Selective β3 agonists arising from strategies to mitigate phase I metabolic transformations
WASHBURN, W. N, HARPER, T. W, DEJNEKA, T, AHMED, S, CARINGAL, Y, HANGELAND, J, ZHANG, M, CHENG, P. T. W, RUSSELL, A. D, SKWISH, S, SLUSARCHYK, D. A, ALLEN, G. T, WU, G, FROHLICH, B. H, ABBOA-OFFEI, B. E, CAP, M, WALDRON, T. L, GEORGE, R. J, TESFAMARIAM, B, DICKINSON, K. E, SEYMOUR, A. A, SHER, P. M, GODFREY, J. D, MCCANN, P, GIROTRA, R, SHAO, C, ZHANG, H, GAVAI, A, MIKKILINENI, A
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Journal Article
BMS-196085 : A potent and selective full agonist of the human β3 adrenergic receptor
GAVAI, A. V, SHER, P. M, WANG, T. C, SUN, C. Q, SLUSARCHYK, D. A, SKWISH, S, ALLEN, G. T, HILLYER, D. E, FROHLICH, B. H, ABBOA-OFFEI, B. E, CAP, M, WALDRON, T. L, MIKKILINENI, A. B, GEORGE, R. J, TESFAMARIAM, B, HARPER, T. W, CIOSEK, C. P, YOUNG, D. A, DICKINSON, K. E, SEYMOUR, A. A, ARBEENY, C. M, WASHBURN, W. N, POSS, K. M, MCCANN, P. J, GIROTRA, R. N, FISHER, L. G, WU, G, BEDNARZ, M. S, MATHUR, A
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
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Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo
Ciosek, C P, Magnin, D R, Harrity, T W, Logan, J V, Dickson, J K, Gordon, E M, Hamilton, K A, Jolibois, K G, Kunselman, L K, Lawrence, R M
Published in The Journal of biological chemistry (25.11.1993)
Published in The Journal of biological chemistry (25.11.1993)
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Journal Article
BMS-196085: a potent and selective full agonist of the human beta(3) adrenergic receptor
Gavai, A V, Sher, P M, Mikkilineni, A B, Poss, K M, McCann, P J, Girotra, R N, Fisher, L G, Wu, G, Bednarz, M S, Mathur, A, Wang, T C, Sun, C Q, Slusarchyk, D A, Skwish, S, Allen, G T, Hillyer, D E, Frohlich, B H, Abboa-Offei, B E, Cap, M, Waldron, T L, George, R J, Tesfamariam, B, Harper, T W, Ciosek, Jr, C P, Young, D A, Dickinson, K E, Seymour, A A, Arbeeny, C M, Washburn, W N
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
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Journal Article
1,1-Bisphosphonate Squalene Synthase Inhibitors: Interplay Between the Isoprenoid Subunit and the Diphosphate Surrogate
Magnin, David R, Dickson, John K, Logan, Janette V, Lawrence, R. Michael, Chen, Ying, Sulsky, Richard B, Ciosek, Carl P, Biller, Scott A, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Rich, Lois C, Slusarchyk, Dorothy A
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
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Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety
Robl, Jeffrey A, Duncan, Laurelee A, Pluscec, Jelka, Karanewsky, Donald S, Gordon, Eric M, Ciosek, Carl P, Rich, Lois C, Dehmel, Viviane C, Slusarchyk, Dorothy A
Published in Journal of medicinal chemistry (01.09.1991)
Published in Journal of medicinal chemistry (01.09.1991)
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Journal Article
Arylpropanolamines: selective beta3 agonists arising from strategies to mitigate phase I metabolic transformations
Washburn, W N, Harper, T W, Wu, G, Godfrey, J D, McCann, P, Girotra, R, Shao, C, Zhang, H, Gavai, A, Mikkilineni, A, Dejneka, T, Ahmed, S, Caringal, Y, Hangeland, J, Zhang, M, Cheng, P T W, Russell, A D, Skwish, S, Slusarchyk, D A, Allen, G T, Frohlich, B H, Abboa-Offei, B E, Cap, M, Waldron, T L, George, R J, Tesfamariam, B, Dickinson, K E, Seymour, A A, Sher, P M
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Journal Article
Arylpropanolamines: Selective beta sub(3) agonists arising from strategies to mitigate phase I metabolic transformations
Washburn, W N, Harper, T W, Wu, G, Godfrey, J D, McCann, P, Girotra, R, Shao, C, Zhang, H, Gavai, A, Mikkilineni, A, Dejneka, T, Ahmed, S, Caringal, Y, Hangeland, J, Zhang, M, Cheng, PTW, Russell, AD, Skwish, S, Slusarchyk, DA, Allen, G T, Frohlich, B H, Abboa-Offei, B E, Cap, M, Waldron, T L, George, R J, Tesfamariam, B, Dickinson, KE, Seymour, A A, Sher, P M
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Journal Article
Enantioselective Synthesis of α-Phosphono Sulfonate Squalene Synthase Inhibitors: Chiral Recognition in the Interactions of an α-Phosphono Sulfonate Inhibitor with Squalene Synthase
Lawrence, R. Michael, Biller, Scott A, Dickson, John K, Logan, Janette V. H, Magnin, David R, Sulsky, Richard B, DiMarco, John D, Gougoutas, Jack Z, Beyer, Barbara D, Taylor, Susan C, Lan, Shih-Jung, Ciosek, Carl P, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Slusarchyk, Dorothy A
Published in Journal of the American Chemical Society (20.11.1996)
Published in Journal of the American Chemical Society (20.11.1996)
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Journal Article
Phosphorus-containing inhibitors of HMG-CoA reductase. II, Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety
ROBL, J. A, DUNCAN, L. A, OBRIEN, K. A, PLUSCEC, J, KARANEWSKY, D. S, GORDON, E. M, CIOSEK, C. P, RICH, L. C, DEHMEL, V. C, SLUSARCHYK, D. A, HARRITY, T. W
Published in Journal of medicinal chemistry (1991)
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Published in Journal of medicinal chemistry (1991)
Journal Article
Aromatic isosteres as conformational probes for an isoprenyl subunit: application to inhibitors of squalene synthase
Biller, Scott A., Abt, Jeffrey W., Pudzianowski, Andrew T., Rich, Lois C., Slusarchyk, Dorothy A., Ciosek, Carl.P.
Published in Bioorganic & medicinal chemistry letters (01.04.1993)
Published in Bioorganic & medicinal chemistry letters (01.04.1993)
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