Antibody Therapeutics in Cancer
Sliwkowski, Mark X., Mellman, Ira
Published in Science (American Association for the Advancement of Science) (13.09.2013)
Published in Science (American Association for the Advancement of Science) (13.09.2013)
Get full text
Journal Article
Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells
Li, Guangmin, Guo, Jun, Shen, Ben-Quan, Yadav, Daniela Bumbaca, Sliwkowski, Mark X, Crocker, Lisa M, Lacap, Jennifer A, Phillips, Gail D Lewis
Published in Molecular cancer therapeutics (01.07.2018)
Published in Molecular cancer therapeutics (01.07.2018)
Get full text
Journal Article
Trastuzumab emtansine: a unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer
LoRusso, Patricia M, Weiss, Denise, Guardino, Ellie, Girish, Sandhya, Sliwkowski, Mark X
Published in Clinical cancer research (15.10.2011)
Published in Clinical cancer research (15.10.2011)
Get full text
Journal Article
Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer
Junttila, Teemu T., Li, Guangmin, Parsons, Kathryn, Phillips, Gail Lewis, Sliwkowski, Mark X.
Published in Breast cancer research and treatment (01.07.2011)
Published in Breast cancer research and treatment (01.07.2011)
Get full text
Journal Article
Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody-Drug Conjugates
Caculitan, Niña G, Dela Cruz Chuh, Josefa, Ma, Yong, Zhang, Donglu, Kozak, Katherine R, Liu, Yichin, Pillow, Thomas H, Sadowsky, Jack, Cheung, Tommy K, Phung, Qui, Haley, Benjamin, Lee, Byoung-Chul, Akita, Robert W, Sliwkowski, Mark X, Polson, Andrew G
Published in Cancer research (Chicago, Ill.) (15.12.2017)
Published in Cancer research (Chicago, Ill.) (15.12.2017)
Get full text
Journal Article
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
Shen, Ben-Quan, Xu, Keyang, Liu, Luna, Raab, Helga, Bhakta, Sunil, Kenrick, Margaret, Parsons-Reponte, Kathryn L, Tien, Janet, Yu, Shang-Fan, Mai, Elaine, Li, Dongwei, Tibbitts, Jay, Baudys, Jakub, Saad, Ola M, Scales, Suzie J, McDonald, Paul J, Hass, Philip E, Eigenbrot, Charles, Nguyen, Trung, Solis, Willy A, Fuji, Reina N, Flagella, Kelly M, Patel, Darshana, Spencer, Susan D, Khawli, Leslie A, Ebens, Allen, Wong, Wai Lee, Vandlen, Richard, Kaur, Surinder, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul, Junutula, Jagath R
Published in Nature biotechnology (01.02.2012)
Published in Nature biotechnology (01.02.2012)
Get full text
Journal Article
Oncogenic ERBB3 Mutations in Human Cancers
Jaiswal, Bijay S., Kljavin, Noelyn M., Stawiski, Eric W., Chan, Emily, Parikh, Chaitali, Durinck, Steffen, Chaudhuri, Subhra, Pujara, Kanan, Guillory, Joseph, Edgar, Kyle A., Janakiraman, Vasantharajan, Scholz, Rolf-Peter, Bowman, Krista K., Lorenzo, Maria, Li, Hong, Wu, Jiansheng, Yuan, Wenlin, Peters, Brock A., Kan, Zhengyan, Stinson, Jeremy, Mak, Michelle, Modrusan, Zora, Eigenbrot, Charles, Firestein, Ron, Stern, Howard M., Rajalingam, Krishnaraj, Schaefer, Gabriele, Merchant, Mark A., Sliwkowski, Mark X., de Sauvage, Frederic J., Seshagiri, Somasekar
Published in Cancer cell (13.05.2013)
Published in Cancer cell (13.05.2013)
Get full text
Journal Article
A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy
Lee-Hoeflich, Si Tuen, Crocker, Lisa, Yao, Evelyn, Pham, Thinh, Munroe, Xander, Hoeflich, Klaus P, Sliwkowski, Mark X, Stern, Howard M
Published in Cancer research (Chicago, Ill.) (15.07.2008)
Published in Cancer research (Chicago, Ill.) (15.07.2008)
Get full text
Journal Article
Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941
Junttila, Teemu T., Akita, Robert W., Parsons, Kathryn, Fields, Carter, Lewis Phillips, Gail D., Friedman, Lori S., Sampath, Deepak, Sliwkowski, Mark X.
Published in Cancer cell (05.05.2009)
Published in Cancer cell (05.05.2009)
Get full text
Journal Article
Phase I Study of Trastuzumab-DM1, an HER2 Antibody-Drug Conjugate, Given Every 3 Weeks to Patients With HER2-Positive Metastatic Breast Cancer
KROP, Ian E, BEERAM, Muralidhar, JACOBSON, Fred, LUTZKER, Stuart G, BURRIS, Howard A, MODI, Shanu, JONES, Suzanne F, HOLDEN, Scott N, WEI YU, GIRISH, Sandhya, TIBBITTS, Jay, YI, Joo-Hee, SLIWKOWSKI, Mark X
Published in Journal of clinical oncology (01.06.2010)
Published in Journal of clinical oncology (01.06.2010)
Get full text
Journal Article
A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies
Schaefer, Gabriele, Haber, Lauric, Crocker, Lisa M., Shia, Steven, Shao, Lily, Dowbenko, Donald, Totpal, Klara, Wong, Anne, Lee, Chingwei V., Stawicki, Scott, Clark, Robyn, Fields, Carter, Lewis Phillips, Gail D., Prell, Rodney A., Danilenko, Dimitry M., Franke, Yvonne, Stephan, Jean-Philippe, Hwang, Jiyoung, Wu, Yan, Bostrom, Jenny, Sliwkowski, Mark X., Fuh, Germaine, Eigenbrot, Charles
Published in Cancer cell (18.10.2011)
Published in Cancer cell (18.10.2011)
Get full text
Journal Article
High cell-surface density of HER2 deforms cell membranes
Chung, Inhee, Reichelt, Mike, Shao, Lily, Akita, Robert W., Koeppen, Hartmut, Rangell, Linda, Schaefer, Gabriele, Mellman, Ira, Sliwkowski, Mark X.
Published in Nature communications (07.09.2016)
Published in Nature communications (07.09.2016)
Get full text
Journal Article
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
Junutula, Jagath R, Mallet, William, Raab, Helga, Clark, Suzanna, Bhakta, Sunil, Leipold, Douglas D, Weir, Sylvia, Chen, Yvonne, Simpson, Michelle, Tsai, Siao Ping, Dennis, Mark S, Lu, Yanmei, Meng, Y Gloria, Ng, Carl, Yang, Jihong, Lee, Chien C, Duenas, Eileen, Gorrell, Jeffrey, Katta, Viswanatham, Kim, Amy, McDorman, Kevin, Flagella, Kelly, Venook, Rayna, Ross, Sarajane, Spencer, Susan D, Lee Wong, Wai, Lowman, Henry B, Vandlen, Richard, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul
Published in Nature biotechnology (01.08.2008)
Published in Nature biotechnology (01.08.2008)
Get full text
Journal Article
Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib
CAREY, Kendall D, GARTON, Andrew J, ROMERO, Maria S, KAHLER, Jennifer, THOMSON, Stuart, ROSS, Sarajane, PARK, Frances, HALEY, John D, GIBSON, Neil, SLIWKOWSKI, Mark X
Published in Cancer research (Chicago, Ill.) (15.08.2006)
Published in Cancer research (Chicago, Ill.) (15.08.2006)
Get full text
Journal Article
The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results
Lewis, Gail D., Li, Guangmin, Guo, Jun, Yu, Shang-Fan, Fields, Carter T., Lee, Genee, Zhang, Donglu, Dragovich, Peter S., Pillow, Thomas, Wei, BinQing, Sadowsky, Jack, Leipold, Douglas, Wilson, Tim, Kamath, Amrita, Mamounas, Michael, Lee, M. Violet, Saad, Ola, Choeurng, Voleak, Ungewickell, Alexander, Monemi, Sharareh, Crocker, Lisa, Kalinsky, Kevin, Modi, Shanu, Jung, Kyung Hae, Hamilton, Erika, LoRusso, Patricia, Krop, Ian, Schutten, Melissa M., Commerford, Renee, Sliwkowski, Mark X., Cho, Eunpi
Published in Nature communications (11.01.2024)
Published in Nature communications (11.01.2024)
Get full text
Journal Article
Clinical Activity of Gemcitabine Plus Pertuzumab in Platinum-Resistant Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
MAKHIJA, Sharmila, AMLER, Lukas C, STRAUSS, Andreas, KELSEY, Stephen, SLIWKOWSKI, Mark X, MATULONIS, Ursula, GLENN, Dana, UELAND, Frederick R, GOLD, Michael A, DIZON, Don S, PATON, Virginia, LIN, Chin-Yu, JANUARIO, Thomas, NG, Kimmie
Published in Journal of clinical oncology (01.03.2010)
Published in Journal of clinical oncology (01.03.2010)
Get full text
Journal Article
Pari passu dimers of dimers
Sliwkowski, Mark X.
Published in Proceedings of the National Academy of Sciences - PNAS (14.08.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (14.08.2012)
Get full text
Journal Article
Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin
Austin, Cary D, De Mazière, Ann M, Pisacane, Paul I, van Dijk, Suzanne M, Eigenbrot, Charles, Sliwkowski, Mark X, Klumperman, Judith, Scheller, Richard H
Published in Molecular biology of the cell (01.12.2004)
Published in Molecular biology of the cell (01.12.2004)
Get full text
Journal Article