Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists
Skudlarek, Jason W., DiMarco, Christina N., Babaoglu, Kerim, Roecker, Anthony J., Bruno, Joseph G., Pausch, Mark A., O'Brien, Julie A., Cabalu, Tamara D., Stevens, Joanne, Brunner, Joseph, Tannenbaum, Pamela L., Wuelfing, W. Peter, Garson, Susan L., Fox, Steven V., Savitz, Alan T., Harrell, Charles M., Gotter, Anthony L., Winrow, Christopher J., Renger, John J., Kuduk, Scott D., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
Get full text
Journal Article
Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii : From Screening Impurity to In Vivo Efficacy
Skudlarek, Jason W., Cooke, Andrew J., Mitchell, Helen J., Babaoglu, Kerim, Shaw, Anthony W., Tong, Ling, Nomland, Ashley B., Labroli, Marc, Sha, Deyou, Mulhearn, James J., Wu, Chengwei, Li, Sarah W., Beshore, Douglas C., Hughes, Jonathan M. E., Jouffroy, Matthieu, Wang, Hao, Balibar, Carl J., Painter, Ronald E., Shen, Pamela, Lange, Henry S., Ishchenko, Andrii, Chen, Yun-Ting, Klein, Daniel J., Tracy, Rodger W., Miller, Randy R., Cabalu, Tamara D., Wu, Zhe, Leithead, Andrew, Scapin, Giovanna, Hruza, Alan W., Dzhekieva, Liudmila, Bukhtiyarova, Marina, Homsher, Michelle F., Xu, Min, Bahnck-Teets, Carolyn, McKenney, David, Buevich, Alexei V., Liu, Jian, Zhang, Li-Kang, Meng, Tao, Kelly, Terri, DiNunzio, Edward, Soisson, Stephen, Cheng, Robert K. Y., Hennig, Michael, Raheem, Izzat, Walker, Scott S.
Published in Journal of medicinal chemistry (12.09.2024)
Published in Journal of medicinal chemistry (12.09.2024)
Get full text
Journal Article
Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties
Kuduk, Scott D., Skudlarek, Jason W., DiMarco, Christina N., Bruno, Joseph G., Pausch, Mark H., O’Brien, Julie A., Cabalu, Tamara D., Stevens, Joanne, Brunner, Joseph, Tannenbaum, Pamela L., Garson, Susan L., Savitz, Alan T., Harrell, Charles M., Gotter, Anthony L., Winrow, Christopher J., Renger, John J., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (15.06.2015)
Published in Bioorganic & medicinal chemistry letters (15.06.2015)
Get full text
Journal Article
Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant
Kuduk, Scott D., Skudlarek, Jason W., Di Marco, Christina N., Bruno, Joseph G., Pausch, Mark A., O’Brien, Julie A., Cabalu, Tamara D., Stevens, Joanne, Brunner, Joseph, Tannenbaum, Pamela L., Gotter, Anthony L., Winrow, Christopher J., Renger, John J., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (01.04.2014)
Published in Bioorganic & medicinal chemistry letters (01.04.2014)
Get full text
Journal Article
Carboxylated, Heteroaryl-Substituted Chalcones as Inhibitors of Vascular Cell Adhesion Molecule-1 Expression for Use in Chronic Inflammatory Diseases
Meng, Charles Q, Ni, Liming, Worsencroft, Kimberly J, Ye, Zhihong, Weingarten, M. David, Simpson, Jacob E, Skudlarek, Jason W, Marino, Elaine M, Suen, Ki-Ling, Kunsch, Charles, Souder, Amy, Howard, Randy B, Sundell, Cynthia L, Wasserman, Martin A, Sikorski, James A
Published in Journal of medicinal chemistry (22.03.2007)
Published in Journal of medicinal chemistry (22.03.2007)
Get full text
Journal Article
Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-α-induced VCAM-1 expression
Meng, Charles Q., Zheng, X.Sharon, Ni, Liming, Ye, Zhihong, Simpson, Jacob E., Worsencroft, Kimberly J., Hotema, Martha R., Weingarten, M.David, Skudlarek, Jason W., Gilmore, Joshua M., Hoong, Lee K., Hill, Russell R., Marino, Elaine M., Suen, Ki-Ling, Kunsch, Charles, Wasserman, Martin A., Sikorski, James A.
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
Get full text
Journal Article
CHEMOKINE RECEPTOR MODULATORS
DOROH BRANDON C, TAHIROVIC YESIM ALTAS, JOHNSON TRICIA L, CLARK MICHAEL P, WAGNER FLORENCE F, LOCKWOOD MARK A, NATCHUS MICHAEL G, WILSON LAWRENCE, WISEMAN JOHN M, SKUDLAREK JASON W
Year of Publication 19.01.2011
Get full text
Year of Publication 19.01.2011
Patent