Plasma MicroRNAs as Sensitive and Specific Biomarkers of Tissue Injury
Laterza, Omar F, Lim, Lee, Garrett-Engele, Philip W, Vlasakova, Katerina, Muniappa, Nagaraja, Tanaka, Wesley K, Johnson, Jason M, Sina, Joseph F, Fare, Thomas L, Sistare, Frank D, Glaab, Warren E
Published in Clinical chemistry (Baltimore, Md.) (01.11.2009)
Published in Clinical chemistry (Baltimore, Md.) (01.11.2009)
Get full text
Journal Article
A Performance Evaluation of Liver and Skeletal Muscle-Specific miRNAs in Rat Plasma to Detect Drug-Induced Injury
Bailey, Wendy J, Barnum, John E, Erdos, Zoltan, LaFranco-Scheuch, Lisa, Lane, Pamela, Vlasakova, Katerina, Sistare, Frank D, Glaab, Warren E
Published in Toxicological sciences (01.03.2019)
Published in Toxicological sciences (01.03.2019)
Get full text
Journal Article
Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline
Kang, Wen, Podtelezhnikov, Alexei A, Tanis, Keith Q, Pacchione, Stephen, Su, Ming, Bleicher, Kimberly B, Wang, Zhibin, Laws, George M, Griffiths, Thomas G, Kuhls, Matthew C, Chen, Qing, Knemeyer, Ian, Marsh, Donald J, Mitra, Kaushik, Lebron, Jose, Sistare, Frank D
Published in Toxicological sciences (01.09.2020)
Published in Toxicological sciences (01.09.2020)
Get full text
Journal Article
Urinary biomarkers trefoil factor 3 and albumin enable early detection of kidney tubular injury
Holder, Daniel, Aslamkhan, Amy G, Shughrue, Paul, Shi, Shu, Muniappa, Nagaraja, Villarreal, Stephanie, Bailey, Wendy, Yu, Yan, Thudium, Douglas, Ozer, Josef S, Figueroa, David J, Clouse, Holly, Troth, Sean P, Jin, Hong, Su, Ming, Sistare, Frank D, Gerhold, David L, Seng, John
Published in Nature biotechnology (01.05.2010)
Published in Nature biotechnology (01.05.2010)
Get full text
Journal Article
A rapid urine test for early detection of kidney injury
Vaidya, Vishal S., Ford, Glen M., Waikar, Sushrut S., Wang, Yizhuo, Clement, Matthew B., Ramirez, Victoria, Glaab, Warren E., Troth, Sean P., Sistare, Frank D., Prozialeck, Walter C., Edwards, Joshua R., Bobadilla, Norma A., Mefferd, Stephen C., Bonventre, Joseph V.
Published in Kidney international (01.07.2009)
Published in Kidney international (01.07.2009)
Get full text
Journal Article
Evaluation of the relative performance of 12 urinary biomarkers for renal safety across 22 rat sensitivity and specificity studies
Vlasakova, Katerina, Erdos, Zoltan, Troth, Sean P, McNulty, Kathleen, Chapeau-Campredon, Valérie, Mokrzycki, Nathalie, Muniappa, Nagaraja, Gu, Yi-Zhong, Holder, Daniel, Bailey, Wendy J, Sistare, Frank D, Glaab, Warren E
Published in Toxicological sciences (01.03.2014)
Published in Toxicological sciences (01.03.2014)
Get full text
Journal Article
ICH S1 prospective evaluation study and weight of evidence assessments: commentary from industry representatives
Vahle, John L., Dybowski, Joe, Graziano, Michael, Hisada, Shigeru, Lebron, Jose, Nolte, Thomas, Steigerwalt, Ronald, Tsubota, Kenjiro, Sistare, Frank D.
Published in Frontiers in toxicology (23.05.2024)
Published in Frontiers in toxicology (23.05.2024)
Get full text
Journal Article
Medical applications of microarray technologies: a regulatory science perspective
Petricoin, 3rd, Emanuel F, Hackett, Joseph L, Lesko, Lawrence J, Puri, Raj K, Gutman, Steven I, Chumakov, Konstantin, Woodcock, Janet, Feigal, Jr, David W, Zoon, Kathryn C, Sistare, Frank D
Published in Nature genetics (01.12.2002)
Published in Nature genetics (01.12.2002)
Get full text
Journal Article
Serum troponins as biomarkers of drug-induced cardiac toxicity
Wallace, Kendall B, Hausner, Elizabeth, Herman, Eugene, Holt, Gordon D, MacGregor, James T, Metz, Alan L, Murphy, Elizabeth, Rosenblum, I Y, Sistare, Frank D, York, Malcolm J
Published in Toxicologic pathology (01.01.2004)
Published in Toxicologic pathology (01.01.2004)
Get more information
Journal Article
Using human genetics to improve safety assessment of therapeutics
Carss, Keren J, Deaton, Aimee M, Del Rio-Espinola, Alberto, Diogo, Dorothée, Fielden, Mark, Kulkarni, Diptee A, Moggs, Jonathan, Newham, Peter, Nelson, Matthew R, Sistare, Frank D, Ward, Lucas D, Yuan, Jing
Published in Nature reviews. Drug discovery (01.02.2023)
Published in Nature reviews. Drug discovery (01.02.2023)
Get full text
Journal Article
Mechanistic Investigations Support Liver Safety of Ubrogepant
Smith, Brenda, Rowe, Josh, Watkins, Paul B, Ashina, Messoud, Woodhead, Jeffrey L, Sistare, Frank D, Goadsby, Peter J
Published in Toxicological sciences (01.09.2020)
Published in Toxicological sciences (01.09.2020)
Get full text
Journal Article
What evidence do we need for biomarker qualification?
Leptak, Chris, Menetski, Joseph P, Wagner, John A, Aubrecht, Jiri, Brady, Linda, Brumfield, Martha, Chin, William W, Hoffmann, Steve, Kelloff, Gary, Lavezzari, Gabriela, Ranganathan, Rajesh, Sauer, John-Michael, Sistare, Frank D, Zabka, Tanja, Wholley, David
Published in Science translational medicine (22.11.2017)
Published in Science translational medicine (22.11.2017)
Get more information
Journal Article
Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats
Gu, Yi-Zhong, Paul, Erina, Vlasakova, Katerina, Troth, Sean P., Sistare, Frank D., Ramaiah, Lila, Potz, Oliver, Sutradhar, Santosh, Glaab, Warren E.
Published in Toxicologic pathology (01.02.2024)
Published in Toxicologic pathology (01.02.2024)
Get full text
Journal Article
Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin
Vlasakova, Katerina, Bourque, Jennifer, Bailey, Wendy J, Patel, Shetal, Besteman, Elizabeth G, Gonzalez, Raymond J, Sistare, Frank D, Glaab, Warren E
Published in Toxicological sciences (26.05.2022)
Published in Toxicological sciences (26.05.2022)
Get full text
Journal Article