Evaluation of various static and dynamic modeling methods to predict clinical CYP3A induction using in vitro CYP3A4 mRNA induction data
Einolf, H J, Chen, L, Fahmi, O A, Gibson, C R, Obach, R S, Shebley, M, Silva, J, Sinz, M W, Unadkat, J D, Zhang, L, Zhao, P
Published in Clinical pharmacology and therapeutics (01.02.2014)
Published in Clinical pharmacology and therapeutics (01.02.2014)
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Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole
HUANG, H, WANG, H, SINZ, M, ZOECKLER, M, STAUDINGER, J, REDINBO, M. R, TEOTICO, D. G, LOCKER, J, KALPANA, G. V, MANI, S
Published in Oncogene (11.01.2007)
Published in Oncogene (11.01.2007)
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Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective
Bohnert, Tonika, Patel, Aarti, Templeton, Ian, Chen, Yuan, Lu, Chuang, Lai, George, Leung, Louis, Tse, Susanna, Einolf, Heidi J, Wang, Ying-Hong, Sinz, Michael, Stearns, Ralph, Walsky, Robert, Geng, Wanping, Sudsakorn, Sirimas, Moore, David, He, Ling, Wahlstrom, Jan, Keirns, Jim, Narayanan, Rangaraj, Lang, Dieter, Yang, Xiaoqing
Published in Drug metabolism and disposition (01.08.2016)
Published in Drug metabolism and disposition (01.08.2016)
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Journal Article
Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes
Sahi, J., Hamilton, G., Sinz, M., Barros, S., Huang, S.-M., Lesko, L. J., LeCluyse, E. L.
Published in Xenobiotica (2000)
Published in Xenobiotica (2000)
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Journal Article
The Effect of Troglitazone Biliary Excretion on Metabolite Distribution and Cholestasis in Transporter-Deficient Rats
KOSTRUBSKY, Vsevolod E, VORE, Mary, KINDT, Erick, BURLIEGH, James, ROGERS, Karen, PETER, Gregory, ALTROGGE, Douglas, SINZ, Michael W
Published in Drug metabolism and disposition (01.12.2001)
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Published in Drug metabolism and disposition (01.12.2001)
Journal Article
Inactivation of Cytochrome P450 3A4 by Bergamottin, a Component of Grapefruit Juice
He, Kan, Iyer, Krishna R, Hayes, Roger N, Sinz, Michael W, Woolf, Thomas F, Hollenberg, Paul F
Published in Chemical research in toxicology (01.04.1998)
Published in Chemical research in toxicology (01.04.1998)
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Journal Article
Evaluation of CYP2B6 Induction and Prediction of Clinical Drug-Drug Interactions: Considerations from the IQ Consortium Induction Working Group-An Industry Perspective
Fahmi, Odette A, Shebley, Mohamad, Palamanda, Jairam, Sinz, Michael W, Ramsden, Diane, Einolf, Heidi J, Chen, Liangfu, Wang, Hongbing
Published in Drug metabolism and disposition (01.10.2016)
Published in Drug metabolism and disposition (01.10.2016)
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Journal Article
Distribution of tacrine and metabolites in rat brain and plasma after single- and multiple-dose regimens. Evidence for accumulation of tacrine in brain tissue
McNally, W P, Pool, W F, Sinz, M W, Dehart, P, Ortwine, D F, Huang, C C, Chang, T, Woolf, T F
Published in Drug metabolism and disposition (01.06.1996)
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Published in Drug metabolism and disposition (01.06.1996)
Journal Article
Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390 : A lead HIV protease inhibitor
VARA PRASAD, J. V. N, BOYER, F. E, HUMBLET, C, LUNNEY, E. A, PAVLOVSKY, A, RUBIN, J. R, FERGUSON, D, GRAHAM, N, HOLLER, T, HUPE, D, NOUHAN, C, TUMMINO, P. J, DOMAGALA, J. M, URUMOV, A, ZEIKUS, E, ZEIKUS, G, GRACHECK, S. J, SAUNDERS, J. M, VANDERROEST, S, BRODFUEHRER, J, IYER, K, SINZ, M, GULNIK, S. V, ELLSWORTH, E. L, ERICKSON, J. W, GAJDA, C, HAMILTON, H. W, HAGEN, S. E, MARKOSKI, L. J, STEINBAUGH, B. A, TAIT, B. D
Published in Bioorganic & medicinal chemistry (01.12.1999)
Published in Bioorganic & medicinal chemistry (01.12.1999)
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Journal Article
In vitro and in vivo disposition of 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide (CI-976) : Identification of a novel five-carbon cleavage metabolite in rats
SINZ, M. W, BLACK, A. E, BJORGE, S. M, HOLMES, A, TRIVEDI, B. K, WOOLF, T. F
Published in Drug metabolism and disposition (1997)
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Published in Drug metabolism and disposition (1997)
Journal Article
CYP3A4 Induction by Drugs: Correlation between a Pregnane X Receptor Reporter Gene Assay and CYP3A4 Expression in Human Hepatocytes
Luo, Gang, Cunningham, Mark, Kim, Sean, Burn, Tim, Lin, Jianrong, Sinz, Michael, Hamilton, Geraldine, Rizzo, Christopher, Jolley, Summer, Gilbert, Darryl, Downey, April, Mudra, Daniel, Graham, Richard, Carroll, Kathy, Xie, Jindong, Madan, Ajay, Parkinson, Andrew, Christ, Dave, Selling, Bernard, LeCluyse, Edward, Gan, Liang-Shang
Published in Drug metabolism and disposition (01.07.2002)
Published in Drug metabolism and disposition (01.07.2002)
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Journal Article
Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions
Sinz, Michael, Kim, Sean, Zhu, Zhengrong, Chen, Taosheng, Anthony, Monique, Dickinson, Kenneth, Rodrigues, A David
Published in Current drug metabolism (01.05.2006)
Published in Current drug metabolism (01.05.2006)
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Journal Article
Electrochemical investigations of a carbon monoxide-oxygen sensor
Lukacs, C., Sinz, M., Staikov, G., Lorenz, W.J., Baier, G., Vogel, A.
Published in Solid state ionics (1994)
Published in Solid state ionics (1994)
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Journal Article
Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays
Zhu, Zhengrong, Kim, Sean, Chen, Taosheng, Lin, Jun-Hsiang, Bell, Aneka, Bryson, James, Dubaquie, Yves, Yan, Ning, Yanchunas, Joseph, Xie, Dianlin, Stoffel, Robert, Sinz, Michael, Dickinson, Kenneth
Published in Journal of biomolecular screening (01.09.2004)
Published in Journal of biomolecular screening (01.09.2004)
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