mTOR Inhibitor RAD001 (Everolimus) Has Antiangiogenic/Vascular Properties Distinct from a VEGFR Tyrosine Kinase Inhibitor
Lane, Heidi A, Wood, Jeanette M, McSheehy, Paul M J, Allegrini, Peter R, Boulay, Anne, Brueggen, Joseph, Littlewood-Evans, Amanda, Maira, Sauveur-Michel, Martiny-Baron, Georg, Schnell, Christian R, Sini, Patrizia, O'Reilly, Terence
Published in Clinical cancer research (01.03.2009)
Published in Clinical cancer research (01.03.2009)
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Journal Article
Wnt3a regulates proliferation and migration of HUVEC via canonical and non-canonical Wnt signaling pathways
Samarzija, Ivana, Sini, Patrizia, Schlange, Thomas, MacDonald, Gwen, Hynes, Nancy E.
Published in Biochemical and biophysical research communications (28.08.2009)
Published in Biochemical and biophysical research communications (28.08.2009)
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Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice
Nolt, Georgia L., Keeble, Alexander R., Wen, Yuan, Strong, Aubrey C., Thomas, Nicholas T., Valentino, Taylor R., Brightwell, Camille R., Murach, Kevin A., Patrizia, Sini, Weinstabl, Harald, Gollner, Andreas, McCarthy, John J., Fry, Christopher S., Franti, Michael, Filareto, Antonio, Peterson, Charlotte A., Dungan, Cory M.
Published in GeroScience (01.04.2024)
Published in GeroScience (01.04.2024)
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Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity
Cummings, Jeffrey, Hodgkinson, Cassandra, Odedra, Rajesh, Sini, Patrizia, Heaton, Simon P, Mundt, Kirsten E, Ward, Tim H, Wilkinson, Robert W, Growcott, Jim, Hughes, Andrew, Dive, Caroline
Published in Molecular cancer therapeutics (01.03.2008)
Published in Molecular cancer therapeutics (01.03.2008)
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The Antitumor and Antiangiogenic Activity of Vascular Endothelial Growth Factor Receptor Inhibition Is Potentiated by ErbB1 Blockade
SINI, Patrizia, WYDER, Lorenza, SCHNELL, Christian, O'REILLY, Terence, LITTLEWOOD, Amanda, BRANDT, Ralph, HYNES, Nancy E, WOOD, Jeanette
Published in Clinical cancer research (15.06.2005)
Published in Clinical cancer research (15.06.2005)
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AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity
CHRESTA, Christine M, DAVIES, Barry R, JAMES, Dominic, HOWARD, Zoe, DUDLEY, Phillippa, HUGHES, Gareth, SMITH, Lisa, MAGUIRE, Sharon, HUMMERSONE, Marc, MALAGU, Karine, MENEAR, Keith, JENKINS, Richard, HICKSON, Ian, JACOBSEN, Matt, SMITH, Graeme C. M, GUICHARD, Sylvie, PASS, Martin, HARDING, Tom, COSULICH, Sabina, CRITCHLOW, Susan E, VINCENT, John P, ELLSTON, Rebecca, JONES, Darren, SINI, Patrizia
Published in Cancer research (Chicago, Ill.) (2010)
Published in Cancer research (Chicago, Ill.) (2010)
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Abstract 703: A novel ATP-competitive MEK/Aurora kinase inhibitor BI-847325 reverses acquired BRAF inhibitor resistance through suppression of Mcl-1 and inhibition of MEK expression
Phadke, Manali S., Sini, Patrizia, Smalley, Keiran
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules
Gollner, Andreas, Rudolph, Dorothea, Weyer-Czernilofsky, Ulrike, Baumgartinger, Rosa, Jung, Peter, Weinstabl, Harald, Ramharter, Jürgen, Grempler, Rolf, Quant, Jens, Rinnenthal, Jörg, Pérez Pitarch, Alejandro, Golubovic, Bojana, Gerlach, Daniel, Bader, Gerd, Wetzel, Kristiane, Otto, Sebastian, Mandl, Christian, Boehmelt, Guido, McConnell, Darryl B, Kraut, Norbert, Sini, Patrizia
Published in Molecular cancer therapeutics (11.09.2024)
Published in Molecular cancer therapeutics (11.09.2024)
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Journal Article
Heterogeneous Profile of ROR1 Protein Expression across Tumor Types
Raso, Maria Gabriela, Barrientos Toro, Elizve, Evans, Kurt, Rizvi, Yasmeen, Lazcano, Rossana, Akcakanat, Argun, Sini, Patrizia, Trapani, Francesca, Madlener, Eva Johanna, Waldmeier, Lorenz, Lazar, Alexander, Meric-Bernstam, Funda
Published in Cancers (15.05.2024)
Published in Cancers (15.05.2024)
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Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases
Sini, Patrizia, Gürtler, Ulrich, Zahn, Stephan K, Baumann, Christoph, Rudolph, Dorothea, Baumgartinger, Rosa, Strauss, Eva, Haslinger, Christian, Tontsch-Grunt, Ulrike, Waizenegger, Irene C, Solca, Flavio, Bader, Gerd, Zoephel, Andreas, Treu, Matthias, Reiser, Ulrich, Garin-Chesa, Pilar, Boehmelt, Guido, Kraut, Norbert, Quant, Jens, Adolf, Günther R
Published in Molecular cancer therapeutics (01.10.2016)
Published in Molecular cancer therapeutics (01.10.2016)
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Abstract LB003: BI 907828: A highly potent MDM2-p53 antagonist suitable for intermittent dose schedules
Gollner, Andreas, Sini, Patrizia, Rudolph, Dorothea, Weinstabl, Harald, Ramharter, Juergen, Weyer-Czernilofsky, Ulrike, Golubovic, Bojana, Grempler, Rolf, Pitarch, Alejandro Pérez, Sailer, Reinhard, McConnell, Darryl B., Kraut, Norbert
Published in Cancer research (Chicago, Ill.) (14.04.2023)
Published in Cancer research (Chicago, Ill.) (14.04.2023)
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Journal Article
Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation
Di Fiore, Pier Paolo, Scita, Giorgio, Sini, Patrizia, Cannas, Angela, Koleske, Anthony J
Published in Nature cell biology (01.03.2004)
Published in Nature cell biology (01.03.2004)
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Inhibition of Multiple Vascular Endothelial Growth Factor Receptors (VEGFR) Blocks Lymph Node Metastases but Inhibition of VEGFR-2 Is Sufficient to Sensitize Tumor Cells to Platinum-Based Chemotherapeutics
SINI, Patrizia, SAMARZIJA, Ivana, SETYONO-HAN, Buddy, WOOD, Jeanette, HYNES, Nancy E, BAFFERT, Fabienne, LITTLEWOOD-EVANS, Amanda, SCHNELL, Christian, THEUER, Andreas, CHRISTIAN, Sven, BOOS, Anja, HESS-STUMPP, Holger, FOEKENS, John A
Published in Cancer research (Chicago, Ill.) (01.03.2008)
Published in Cancer research (Chicago, Ill.) (01.03.2008)
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Abstract 1919: Pharmacological characterization of BI 847325, a dual inhibitor of MEK and Aurora kinases
Sini, Patrizia, Gürtler, Ulrich, Zahn, Stephan K., Boehmelt, Guido, Garin-Chesa, Pilar, Kraut, Nobert, Rudolph, Dorothea, Solca, Flavio, Tontsch-Grunt, Ulrike, Waizenegger, Irene C., Adolf, Günther R.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia
ALFEREZ, DENIS G, GOODLAD, ROBERT A, ODEDRA, RAJESH, SINI, PATRIZIA, CRAFTER, CLAIRE, RYAN, ANDERSON J, WEDGE, STEPHEN R, WRIGHT, NICHOLAS A, ANDERSON, ELIZABETH, WILKINSON, ROBERT W
Published in International journal of oncology (01.10.2012)
Published in International journal of oncology (01.10.2012)
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Journal Article
An Effector Region in Eps8 Is Responsible for the Activation of the Rac-Specific GEF Activity of Sos-1 and for the Proper Localization of the Rac-Based Actin-Polymerizing Machine
Scita, Giorgio, Tenca, Pierluigi, Areces, Liliana B., Tocchetti, Arianna, Frittoli, Emanuela, Giardina, Giuseppina, Ponzanelli, Isabella, Sini, Patrizia, Innocenti, Metello, Di Fiore, Pier Paolo
Published in The Journal of cell biology (03.09.2001)
Published in The Journal of cell biology (03.09.2001)
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