What is an “ideal” antibiotic? Discovery challenges and path forward
Singh, Sheo B., Young, Katherine, Silver, Lynn L.
Published in Biochemical pharmacology (01.06.2017)
Published in Biochemical pharmacology (01.06.2017)
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Journal Article
Antibacterial and mechanism of action studies of boxazomycin A
Singh, Sheo B., Occi, James, Ondeyka, John, Barrett, John F., Masurekar, Prakash, Motyl, Mary, Gill, Charles, Salituro, Gino
Published in Journal of antibiotics (01.08.2024)
Published in Journal of antibiotics (01.08.2024)
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Journal Article
History and Prospects of Drug Discovery and Development Collaboration between Industry and Academia
Singh, Sheo B., Martin, Gary E., McKittrick, Brian, Crowther, Jonathan, Fraenkel, Howard, Lunn, Charles, Bayne, Marvin, Perkins, John B., Gullo, Vincent
Published in Journal of natural products (Washington, D.C.) (26.04.2024)
Published in Journal of natural products (Washington, D.C.) (26.04.2024)
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Journal Article
Structures of Kibdelomycin Bound to Staphylococcus aureus GyrB and ParE Showed a Novel U‑Shaped Binding Mode
Lu, Jun, Patel, Sangita, Sharma, Nandini, Soisson, Stephen M, Kishii, Ryuta, Takei, Masaya, Fukuda, Yasumichi, Lumb, Kevin J, Singh, Sheo B
Published in ACS chemical biology (19.09.2014)
Published in ACS chemical biology (19.09.2014)
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Journal Article
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties
Wang, Jun, Kodali, Srinivas, Lee, Sang Ho, Galgoci, Andrew, Painter, Ronald, Dorso, Karen, Racine, Fred, Motyl, Mary, Hernandez, Lorraine, Tinney, Elizabeth, Colletti, Steven L, Herath, Kithsiri, Cummings, Richard, Salazar, Oscar, González, Ignacio, Basilio, Angela, Vicente, Francisca, Genilloud, Olga, Pelaez, Fernando, Jayasuriya, Hiranthi, Young, Katherine, Cully, Doris F, Singh, Sheo B
Published in Proceedings of the National Academy of Sciences - PNAS (01.05.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (01.05.2007)
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Journal Article
Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes
Wu, Margaret, Singh, Sheo B, Wang, Jun, Chung, Christine C, Salituro, Gino, Karanam, Bindhu V, Lee, Sang Ho, Powles, Maryann, Ellsworth, Kenneth P, Lassman, Michael E, Miller, Corey, Myers, Robert W, Tota, Michael R, Zhang, Bei B, Li, Cai
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2011)
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Journal Article
The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys
Singh, Sheo B, Kang, Ling, Nawrocki, Andrea R, Zhou, Dan, Wu, Margaret, Previs, Stephen, Miller, Corey, Liu, Haiying, Hines, Catherine D G, Madeira, Maria, Cao, Jin, Herath, Kithsiri, Spears, Larry D, Semenkovich, Clay F, Wang, Liangsu, Kelley, David E, Li, Cai, Guan, Hong-Ping
Published in PloS one (03.10.2016)
Published in PloS one (03.10.2016)
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Journal Article
Nocathiacin, Thiazomycin, and Polar Analogs Are Highly Effective Agents against Toxigenic Clostridioides difficile
Singh, Sheo B, Miesel, Lynn, Kramer, Susanne, Xu, Libo, Li, Fangbio, Lan, Jing, Lipari, Phillip, Polishook, Jon D, Liu, Gongjie, Liang, Lianzhu, Flattery, Amy M
Published in Journal of natural products (Washington, D.C.) (22.04.2022)
Published in Journal of natural products (Washington, D.C.) (22.04.2022)
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Journal Article
Kibdelomycin is a bactericidal broad-spectrum aerobic antibacterial agent
Singh, Sheo B, Dayananth, Priya, Balibar, Carl J, Garlisi, Charles G, Lu, Jun, Kishii, Ryuta, Takei, Masaya, Fukuda, Yasumichi, Ha, Sookhee, Young, Katherine
Published in Antimicrobial agents and chemotherapy (01.06.2015)
Published in Antimicrobial agents and chemotherapy (01.06.2015)
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Journal Article
Structure activity relationship of N-1 substituted 1,5-naphthyrid-2-one analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-9)
Singh, Sheo B., Tan, Christopher M., Kaelin, David, Meinke, Peter T., Miesel, Lynn, Olsen, David B., Fukuda, Hideyuki, Kishii, Ryuta, Takei, Masaya, Ohata, Kohei, Takeuchi, Tomoko, Shibue, Taku, Takano, Hisashi, Nishimura, Akinori, Fukuda, Yasumichi
Published in Bioorganic & medicinal chemistry letters (01.11.2022)
Published in Bioorganic & medicinal chemistry letters (01.11.2022)
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Journal Article
Screening strategies for discovery of antibacterial natural products
Singh, Sheo B, Young, Katherine, Miesel, Lynn
Published in Expert review of anti-infective therapy (01.08.2011)
Published in Expert review of anti-infective therapy (01.08.2011)
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Journal Article
Rapid, Selective, and Sensitive Method for Semitargeted Discovery of Congeneric Natural Products by Liquid Chromatography Tandem Mass Spectrometry
Herath, Kithsiri B, Previs, Stephen F, Roddy, Thomas P, Attygalle, Athula B, González, Ignacio, Genilloud, Olga, Singh, Sheo B
Published in Journal of natural products (Washington, D.C.) (26.03.2021)
Published in Journal of natural products (Washington, D.C.) (26.03.2021)
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Journal Article
Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation
Kondapaka, Sudhir B, Singh, Sheo S, Dasmahapatra, Girija P, Sausville, Edward A, Roy, Krishnendu K
Published in Molecular cancer therapeutics (01.11.2003)
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Published in Molecular cancer therapeutics (01.11.2003)
Journal Article
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Colwell, Lawrence, Becker, Joseph W, Parthasarathy, Gopalakrishnan, Tang, Yui S, Basilio, Ángela, Cummings, Richard, Hermes, Jeffery D, Lee, Sang Ho, Dorso, Karen, Motyl, Mary, Soisson, Stephen M, Shoop, Wesley, Genilloud, Olga, Vicente, Francisca, Silver, Lynn L, Singh, Sheo B, Kodali, Srinivas, Jayasuriya, Hiranthi, Bartizal, Ken, Cully, Doris, Barrett, John, Allocco, John, Pelaez, Fernando, Wang, Jun, Young, Katherine, Painter, Ronald, Michael, Bruce, Hernandez, Lorraine, Felcetto, Thomas, Galgoci, Andrew, Gill, Charles, Tormo, José R, Schmatz, Dennis, Zhang, Chaowei, Ondeyka, John, Herath, Kithsiri, Ha, Sookhee
Published in Nature (18.05.2006)
Published in Nature (18.05.2006)
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Journal Article