Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro
Nguyen, Deborah G, Funk, Juergen, Robbins, Justin B, Crogan-Grundy, Candace, Presnell, Sharon C, Singer, Thomas, Roth, Adrian B
Published in PloS one (07.07.2016)
Published in PloS one (07.07.2016)
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Journal Article
A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity
Kostadinova, Radina, Boess, Franziska, Applegate, Dawn, Suter, Laura, Weiser, Thomas, Singer, Thomas, Naughton, Brian, Roth, Adrian
Published in Toxicology and applied pharmacology (01.04.2013)
Published in Toxicology and applied pharmacology (01.04.2013)
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Journal Article
Scales of Lewis Basicities toward C‑Centered Lewis Acids (Carbocations)
Mayr, Herbert, Ammer, Johannes, Baidya, Mahiuddin, Maji, Biplab, Nigst, Tobias A, Ofial, Armin R, Singer, Thomas
Published in Journal of the American Chemical Society (25.02.2015)
Published in Journal of the American Chemical Society (25.02.2015)
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Journal Article
The Immunogenicity of Antibody Aggregates in a Novel Transgenic Mouse Model
Bessa, Juliana, Boeckle, Sabine, Beck, Hermann, Buckel, Thomas, Schlicht, Sonja, Ebeling, Martin, Kiialainen, Anna, Koulov, Atanas, Boll, Björn, Weiser, Thomas, Singer, Thomas, Rolink, Antonius G., Iglesias, Antonio
Published in Pharmaceutical research (01.07.2015)
Published in Pharmaceutical research (01.07.2015)
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Brain Shuttle Antibody for Alzheimer’s Disease with Attenuated Peripheral Effector Function due to an Inverted Binding Mode
Weber, Felix, Bohrmann, Bernd, Niewoehner, Jens, Fischer, Jens A.A., Rueger, Petra, Tiefenthaler, Georg, Moelleken, Joerg, Bujotzek, Alexander, Brady, Kevin, Singer, Thomas, Ebeling, Martin, Iglesias, Antonio, Freskgård, Per-Ola
Published in Cell reports (Cambridge) (02.01.2018)
Published in Cell reports (Cambridge) (02.01.2018)
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Genome-based analysis of the nonhuman primate Macaca fascicularis as a model for drug safety assessment
Ebeling, Martin, Küng, Erich, See, Angela, Broger, Clemens, Steiner, Guido, Berrera, Marco, Heckel, Tobias, Iniguez, Leonardo, Albert, Thomas, Schmucki, Roland, Biller, Hermann, Singer, Thomas, Certa, Ulrich
Published in Genome research (01.10.2011)
Published in Genome research (01.10.2011)
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A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides
Dieckmann, Andreas, Hagedorn, Peter H., Burki, Yvonne, Brügmann, Christine, Berrera, Marco, Ebeling, Martin, Singer, Thomas, Schuler, Franz
Published in Molecular therapy. Nucleic acids (02.03.2018)
Published in Molecular therapy. Nucleic acids (02.03.2018)
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Journal Article
Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia
Sewing, Sabine, Roth, Adrian B, Winter, Michael, Dieckmann, Andreas, Bertinetti-Lapatki, Cristina, Tessier, Yann, McGinnis, Claudia, Huber, Sylwia, Koller, Erich, Ploix, Corinne, Reed, John C, Singer, Thomas, Rothfuss, Andreas
Published in PloS one (06.11.2017)
Published in PloS one (06.11.2017)
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Journal Article
Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies
Kerns, S Jordan, Belgur, Chaitra, Petropolis, Debora, Kanellias, Marianne, Barrile, Riccardo, Sam, Johannes, Weinzierl, Tina, Fauti, Tanja, Freimoser-Grundschober, Anne, Eckmann, Jan, Hage, Carina, Geiger, Martina, Ng, Patrick Ray, Tien-Street, William, Manatakis, Dimitris V, Micallef, Virginie, Gerard, Regine, Bscheider, Michael, Breous-Nystrom, Ekaterina, Schneider, Anneliese, Giusti, Anna Maria, Bertinetti-Lapatki, Cristina, Grant, Heather Shannon, Roth, Adrian B, Hamilton, Geraldine A, Singer, Thomas, Karalis, Katia, Moisan, Annie, Bruenker, Peter, Klein, Christian, Bacac, Marina, Gjorevski, Nikolce, Cabon, Lauriane
Published in eLife (11.08.2021)
Published in eLife (11.08.2021)
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Journal Article
Nucleophilicities and Carbon Basicities of Pyridines
Brotzel, Frank, Kempf, Bernhard, Singer, Thomas, Zipse, Hendrik, Mayr, Herbert
Published in Chemistry : a European journal (2007)
Published in Chemistry : a European journal (2007)
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Journal Article
Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs
Sewing, Sabine, Boess, Franziska, Moisan, Annie, Bertinetti-Lapatki, Cristina, Minz, Tanja, Hedtjaern, Maj, Tessier, Yann, Schuler, Franz, Singer, Thomas, Roth, Adrian B
Published in PloS one (21.07.2016)
Published in PloS one (21.07.2016)
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Journal Article
Application of Imaging Techniques to Cases of Drug-Induced Crystal Nephropathy in Preclinical Studies
Lenz, Barbara, Brink, Andreas, Siam, Monira, De Paepe, Anne, Bassett, Simon, Eichinger-Chapelon, Anne, Maliver, Pierre, Neff, Rachel, Niederhauser, Urs, Steinhuber, Bernd, Zurbach, Raphael, Singer, Thomas, Funk, Christoph, Schuler, Franz, Albassam, Mudher, Schadt, Simone
Published in Toxicological sciences (01.06.2018)
Published in Toxicological sciences (01.06.2018)
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Journal Article
In Silico Assay for Assessing Phospholipidosis Potential of Small Druglike Molecules: Training, Validation, and Refinement Using Several Data Sets
Fischer, Holger, Atzpodien, Elke-Astrid, Csato, Miklos, Doessegger, Lucette, Lenz, Barbara, Schmitt, Georg, Singer, Thomas
Published in Journal of medicinal chemistry (12.01.2012)
Published in Journal of medicinal chemistry (12.01.2012)
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Journal Article
Culture and Drug Profiling of Patient Derived Malignant Pleural Effusions for Personalized Cancer Medicine
Ruiz, Christian, Kustermann, Stefan, Pietilae, Elina, Vlajnic, Tatjana, Baschiera, Betty, Arabi, Leila, Lorber, Thomas, Oeggerli, Martin, Savic, Spasenija, Obermann, Ellen, Singer, Thomas, Rothschild, Sacha I, Zippelius, Alfred, Roth, Adrian B, Bubendorf, Lukas
Published in PloS one (22.08.2016)
Published in PloS one (22.08.2016)
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Journal Article
Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration
Zheng, Yanan, Tesar, Devin B., Benincosa, Lisa, Birnböck, Herbert, Boswell, C. Andrew, Bumbaca, Daniela, Cowan, Kyra J, Danilenko, Dimitry M., Daugherty, Ann L., Fielder, Paul J., Grimm, Hans Peter, Joshi, Amita, Justies, Nicole, Kolaitis, Gerry, Lewin-Koh, Nicholas, Li, Jing, McVay, Sami, O'Mahony, Jennifer, Otteneder, Michael, Pantze, Michael, Putnam, Wendy S., Qiu, Zhihua J., Ruppel, Jane, Singer, Thomas, Stauch, Oliver, Theil, Frank-Peter, Visich, Jennifer, Yang, Jihong, Ying, Yong, Khawli, Leslie A., Richter, Wolfgang F.
Published in mAbs (01.03.2012)
Published in mAbs (01.03.2012)
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Unraveling the deep learning gearbox in optical coherence tomography image segmentation towards explainable artificial intelligence
Maloca, Peter M, Müller, Philipp L, Lee, Aaron Y, Tufail, Adnan, Balaskas, Konstantinos, Niklaus, Stephanie, Kaiser, Pascal, Suter, Susanne, Zarranz-Ventura, Javier, Egan, Catherine, Scholl, Hendrik P N, Schnitzer, Tobias K, Singer, Thomas, Hasler, Pascal W, Denk, Nora
Published in Communications biology (05.02.2021)
Published in Communications biology (05.02.2021)
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