Slowing ageing by design: the rise of NAD + and sirtuin-activating compounds
Bonkowski, Michael S, Sinclair, David A
Published in Nature reviews. Molecular cell biology (01.11.2016)
Published in Nature reviews. Molecular cell biology (01.11.2016)
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Journal Article
Sirtuin activators and inhibitors: Promises, achievements, and challenges
Dai, Han, Sinclair, David A., Ellis, James L., Steegborn, Clemens
Published in Pharmacology & therapeutics (Oxford) (01.08.2018)
Published in Pharmacology & therapeutics (Oxford) (01.08.2018)
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Journal Article
Small molecule SIRT1 activators for the treatment of aging and age-related diseases
Hubbard, Basil P, Sinclair, David A
Published in Trends in pharmacological sciences (Regular ed.) (01.03.2014)
Published in Trends in pharmacological sciences (Regular ed.) (01.03.2014)
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Journal Article
Why does COVID-19 disproportionately affect older people?
Mueller, Amber L, McNamara, Maeve S, Sinclair, David A
Published in Aging (Albany, NY.) (29.05.2020)
Published in Aging (Albany, NY.) (29.05.2020)
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Journal Article
Small-molecule allosteric activators of sirtuins
Sinclair, David A, Guarente, Leonard
Published in Annual review of pharmacology and toxicology (01.01.2014)
Published in Annual review of pharmacology and toxicology (01.01.2014)
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Journal Article
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside
Winnik, Stephan, Auwerx, Johan, Sinclair, David A, Matter, Christian M
Published in European heart journal (21.12.2015)
Published in European heart journal (21.12.2015)
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Journal Article
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
Gomes, Ana P., Price, Nathan L., Ling, Alvin J.Y., Moslehi, Javid J., Montgomery, Magdalene K., Rajman, Luis, White, James P., Teodoro, João S., Wrann, Christiane D., Hubbard, Basil P., Mercken, Evi M., Palmeira, Carlos M., de Cabo, Rafael, Rolo, Anabela P., Turner, Nigel, Bell, Eric L., Sinclair, David A.
Published in Cell (19.12.2013)
Published in Cell (19.12.2013)
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Journal Article
NAD + in Brain Aging and Neurodegenerative Disorders
Lautrup, Sofie, Sinclair, David A, Mattson, Mark P, Fang, Evandro F
Published in Cell metabolism (01.10.2019)
Published in Cell metabolism (01.10.2019)
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Journal Article
Epigenetic changes during aging and their reprogramming potential
Kane, Alice E., Sinclair, David A.
Published in Critical reviews in biochemistry and molecular biology (02.01.2019)
Published in Critical reviews in biochemistry and molecular biology (02.01.2019)
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Journal Article
NAD+ in COVID-19 and viral infections
Zheng, Minyan, Schultz, Michael B., Sinclair, David A.
Published in Trends in immunology (01.04.2022)
Published in Trends in immunology (01.04.2022)
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Journal Article
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, João A, Coppotelli, Giuseppe, Rolo, Anabela P, Palmeira, Carlos M, Ross, Jaime M, Sinclair, David A
Published in Nature reviews. Endocrinology (01.04.2022)
Published in Nature reviews. Endocrinology (01.04.2022)
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Journal Article