Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Sinclair, David A, Howitz, Konrad T, Bitterman, Kevin J, Cohen, Haim Y, Lamming, Dudley W, Lavu, Siva, Wood, Jason G, Zipkin, Robert E, Chung, Phuong, Kisielewski, Anne, Zhang, Li-Li, Scherer, Brandy
Published in Nature (11.09.2003)
Published in Nature (11.09.2003)
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Journal Article
Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1
Bitterman, Kevin J, Anderson, Rozalyn M, Cohen, Haim Y, Latorre-Esteves, Magda, Sinclair, David A
Published in The Journal of biological chemistry (22.11.2002)
Published in The Journal of biological chemistry (22.11.2002)
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Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet
Palliyaguru, Dushani L, Minor, Robin K, Mitchell, Sarah J, Palacios, Hector H, Licata, Jordan J, Ward, Theresa M, Abulwerdi, Gelareh, Elliott, Peter, Westphal, Christoph, Ellis, James L, Sinclair, David A, Price, Nathan L, Bernier, Michel, de Cabo, Rafael
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.11.2020)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.11.2020)
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Static Socio-Ecological COVID-19 Vulnerability Index and Vaccine Hesitancy Index for England
Welsh, Claire E., Sinclair, David R., Matthews, Fiona E.
Published in The Lancet regional health. Europe (01.03.2022)
Published in The Lancet regional health. Europe (01.03.2022)
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Journal Article
SIRT1 is essential for normal cognitive function and synaptic plasticity
Michán, Shaday, Li, Ying, Chou, Maggie Meng-Hsiu, Parrella, Edoardo, Ge, Huanying, Long, Jeffrey M, Allard, Joanne S, Lewis, Kaitlyn, Miller, Marshall, Xu, Wei, Mervis, Ronald F, Chen, Jing, Guerin, Karen I, Smith, Lois E H, McBurney, Michael W, Sinclair, David A, Baudry, Michel, de Cabo, Rafael, Longo, Valter D
Published in The Journal of neuroscience (21.07.2010)
Published in The Journal of neuroscience (21.07.2010)
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Augmented reality in neurovascular surgery: feasibility and first uses in the operating room
Kersten-Oertel, Marta, Gerard, Ian, Drouin, Simon, Mok, Kelvin, Sirhan, Denis, Sinclair, David S., Collins, D. Louis
Published in International journal for computer assisted radiology and surgery (01.11.2015)
Published in International journal for computer assisted radiology and surgery (01.11.2015)
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Journal Article
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
Brunet, Anne, Sweeney, Lora B., Sturgill, J. Fitzhugh, Chua, Katrin F., Greer, Paul L., Lin, Yingxi, Tran, Hien, Ross, Sarah E., Mostoslavsky, Raul, Cohen, Haim Y., Hu, Linda S., Cheng, Hwei-Ling, Jedrychowski, Mark P., Gygi, Steven P., Sinclair, David A., Alt, Frederick W., Greenberg, Michael E.
Published in Science (American Association for the Advancement of Science) (26.03.2004)
Published in Science (American Association for the Advancement of Science) (26.03.2004)
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Galactic cosmic radiation exposure causes multifaceted neurocognitive impairments
Alaghband, Yasaman, Klein, Peter M., Kramár, Eniko A., Cranston, Michael N., Perry, Bayley C., Shelerud, Lukas M., Kane, Alice E., Doan, Ngoc-Lien, Ru, Ning, Acharya, Munjal M., Wood, Marcelo A., Sinclair, David A., Dickstein, Dara L., Soltesz, Ivan, Limoli, Charles L., Baulch, Janet E.
Published in Cellular and molecular life sciences : CMLS (01.01.2023)
Published in Cellular and molecular life sciences : CMLS (01.01.2023)
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C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins
Anderson, Edward N., Corkins, Mark E., Li, Jia-Cheng, Singh, Komudi, Parsons, Sadé, Tucey, Tim M., Sorkaç, Altar, Huang, Huiyan, Dimitriadi, Maria, Sinclair, David A., Hart, Anne C.
Published in Mechanisms of ageing and development (01.03.2016)
Published in Mechanisms of ageing and development (01.03.2016)
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Journal Article
SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance
Osborne, Brenna, Wright, Lauren E, Brandon, Amanda E, Stuart, Ella, Small, Lewin, Hoeks, Joris, Schrauwen, Patrick, Sinclair, David A, Montgomery, Magdalene K, Cooney, Gregory J, Turner, Nigel
Published in Journal of endocrinology (01.09.2023)
Published in Journal of endocrinology (01.09.2023)
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Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer‐based precipitation and size exclusion chromatography
Martínez‐Greene, Juan A., Hernández‐Ortega, Karina, Quiroz‐Baez, Ricardo, Resendis‐Antonio, Osbaldo, Pichardo‐Casas, Israel, Sinclair, David A., Budnik, Bogdan, Hidalgo‐Miranda, Alfredo, Uribe‐Querol, Eileen, Ramos‐Godínez, María del Pilar, Martínez‐Martínez, Eduardo
Published in Journal of extracellular vesicles (01.04.2021)
Published in Journal of extracellular vesicles (01.04.2021)
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Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice
Strong, Randy, Miller, Richard A, Astle, Clinton M, Baur, Joseph A, de Cabo, Rafael, Fernandez, Elizabeth, Guo, Wen, Javors, Martin, Kirkland, James L, Nelson, James F, Sinclair, David A, Teter, Bruce, Williams, David, Zaveri, Nurulain, Nadon, Nancy L, Harrison, David E
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.01.2013)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.01.2013)
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Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice
Ross, Jaime M., Coppotelli, Giuseppe, Branca, Rui M., Kim, Kyung M., Lehtiö, Janne, Sinclair, David A., Olson, Lars
Published in Aging cell (01.12.2019)
Published in Aging cell (01.12.2019)
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Journal Article
Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein
Bernier, Michel, Paul, Rajib K., Martin-Montalvo, Alejandro, Scheibye-Knudsen, Morten, Song, Shaoming, He, Hua-Jun, Armour, Sean M., Hubbard, Basil P., Bohr, Vilhelm A., Wang, Lili, Zong, Yaping, Sinclair, David A., de Cabo, Rafael
Published in The Journal of biological chemistry (03.06.2011)
Published in The Journal of biological chemistry (03.06.2011)
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Journal Article
Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila
Bosch, Justin A, Ugur, Berrak, Pichardo-Casas, Israel, Rabasco, Jordan, Escobedo, Felipe, Zuo, Zhongyuan, Brown, Ben, Celniker, Susan, Sinclair, David A, Bellen, Hugo J, Perrimon, Norbert
Published in eLife (08.11.2022)
Published in eLife (08.11.2022)
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