Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro
Ferrigno, Federica, Biancofiore, Ilaria, Malancona, Savina, Ponzi, Simona, Paonessa, Giacomo, Graziani, Rita, Bresciani, Alberto, Gennari, Nadia, Di Marco, Annalise, Kaiser, Marcel, Summa, Vincenzo, Harper, Steven, Ontoria, Jesus M.
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
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Identification of thieno[3,2- b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase
Ontoria, Jesus M., Martìn Hernando, Jose I., Malancona, Savina, Attenni, Barbara, Stansfield, Ian, Conte, Immacolata, Ercolani, Caterina, Habermann, Jörg, Ponzi, Simona, Di Filippo, Marcello, Koch, Uwe, Rowley, Michael, Narjes, Frank
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
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Optimization of Thienopyrrole‐Based Finger‐Loop Inhibitors of the Hepatitis C Virus NS5B Polymerase
Martin Hernando, Jose Ignacio, Ontoria, Jesus Maria, Malancona, Savina, Attenni, Barbara, Fiore, Fabrizio, Bonelli, Fabio, Koch, Uwe, Di Marco, Stefania, Colarusso, Stefania, Ponzi, Simona, Gennari, Nadia, Vignetti, Sue Ellen, del Rosario Rico Ferreira, Maria, Habermann, Jörg, Rowley, Michael, Narjes, Frank
Published in ChemMedChem (05.10.2009)
Published in ChemMedChem (05.10.2009)
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Direct-to-biology platform: From synthesis to biological evaluation of SHP2 allosteric inhibitors
Ponzi, Simona, Ferrigno, Federica, Bisbocci, Monica, Alli, Cristina, Ontoria, Jesus M., Petrocchi, Alessia, Toniatti, Carlo, Torrente, Esther
Published in Bioorganic & medicinal chemistry letters (01.03.2024)
Published in Bioorganic & medicinal chemistry letters (01.03.2024)
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SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease
Colarusso, Stefania, Ferrigno, Federica, Ponzi, Simona, Pavone, Francesca, Conte, Immacolata, Abate, Luigi, Beghetto, Elisa, Missineo, Antonino, Amaudrut, Jerome, Bresciani, Alberto, Paonessa, Giacomo, Tomei, Licia, Montalbetti, Christian, Bianchi, Elisabetta, Toniatti, Carlo, Ontoria, Jesus M.
Published in Bioorganic & medicinal chemistry (01.03.2022)
Published in Bioorganic & medicinal chemistry (01.03.2022)
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Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors
Ponzi, Simona, Bresciani, Alberto, Kaiser, Marcel, Nardi, Valentina, Nizi, Emanuela, Ontoria, Jesus M., Pace, Paola, Paonessa, Giacomo, Summa, Vincenzo, Harper, Steven
Published in Bioorganic & medicinal chemistry letters (15.04.2020)
Published in Bioorganic & medicinal chemistry letters (15.04.2020)
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Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors
Torrente, Esther, Fodale, Valentina, Ciammaichella, Alina, Ferrigno, Federica, Ontoria, Jesus M., Ponzi, Simona, Rossetti, Ilaria, Sferrazza, Alessio, Amaudrut, Jérôme, Missineo, Antonino, Esposito, Simone, Palombo, Simone, Nibbio, Martina, Cerretani, Mauro, Bisbocci, Monica, Cellucci, Antonella, di Marco, Annalise, Alli, Cristina, Pucci, Vincenzo, Toniatti, Carlo, Petrocchi, Alessia
Published in ACS medicinal chemistry letters (09.02.2023)
Published in ACS medicinal chemistry letters (09.02.2023)
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Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT
Ciammaichella, Alina, Ferrigno, Federica, Basta, Andreina, D'Amico, Melania, Biancofiore, Ilaria, Nardi, Valentina, Ponzi, Simona, Graziani, Rita, Gennari, Nadia, Vittoria Orsale, Maria, Fini, Ivan, Paonessa, Giacomo, Summa, Vincenzo, Harper, Steven, Ontoria, Jesus M.
Published in Bioorganic & medicinal chemistry letters (15.06.2020)
Published in Bioorganic & medicinal chemistry letters (15.06.2020)
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Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides
Bresciani, Alberto, Ontoria, Jesus M, Biancofiore, Ilaria, Cellucci, Antonella, Ciammaichella, Alina, Di Marco, Annalise, Ferrigno, Federica, Francone, Alessandra, Malancona, Savina, Monteagudo, Edith, Nizi, Emanuela, Pace, Paola, Ponzi, Simona, Rossetti, Ilaria, Veneziano, Maria, Summa, Vincenzo, Harper, Steven
Published in ACS medicinal chemistry letters (11.04.2019)
Published in ACS medicinal chemistry letters (11.04.2019)
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Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs
Ontoria, Jesus M, Paonessa, Giacomo, Ponzi, Simona, Ferrigno, Federica, Nizi, Emanuela, Biancofiore, Ilaria, Malancona, Savina, Graziani, Rita, Roberts, David, Willis, Paul, Bresciani, Alberto, Gennari, Nadia, Cecchetti, Ottavia, Monteagudo, Edith, Orsale, Maria V, Veneziano, Maria, Di Marco, Annalise, Cellucci, Antonella, Laufer, Ralph, Altamura, Sergio, Summa, Vincenzo, Harper, Steven
Published in ACS medicinal chemistry letters (12.05.2016)
Published in ACS medicinal chemistry letters (12.05.2016)
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Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid
STANSFIELD, Ian, AVOLIO, Salvatore, COLARUSSO, Stefania, GENNARI, Nadia, NARJES, Frank, PACINI, Barbara, PONZI, Simona, HARPER, Steven
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
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Synthesis of Indolo[2,1-a][2]benzazepine and Indolo[2,1-a][2]-benzazocine
Ponzi, Simona, Habermann, Joerg, Ferreira, Maria del Rosario Rico, Narjes, Frank
Published in Synlett (03.06.2009)
Published in Synlett (03.06.2009)
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Journal Article
Capped dipeptide α-Ketoacid inhibitors of the HCV NS3 protease
Nizi, Emanuela, Koch, Uwe, Ponzi, Simona, Matassa, Victor G, Gardelli, Cristina
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
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Journal Article
SHP2 INHIBITORS
SFERRAZZA, Alessio, PONZI, Simona, ROSSETTI, Ilaria, FERRIGNO, Federica, ONTORIA ONTORIA, Jesus Maria, TORRENTE, Esther, PETROCCHI, Alessia, CIAMMAICHELLA, Alina
Year of Publication 15.09.2022
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Year of Publication 15.09.2022
Patent
SHP2 INHIBITORS
SFERRAZZA, Alessio, PONZI, Simona, ROSSETTI, Ilaria, FERRIGNO, Federica, ONTORIA ONTORIA, Jesus Maria, TORRENTE, Esther, PETROCCHI, Alessia, CIAMMAICHELLA, Alina
Year of Publication 15.06.2022
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Year of Publication 15.06.2022
Patent
SHP2 INHIBITORS
ROSSETTI, ILARIA, TORRENTE, ESTHER, PETROCCHI, ALESSIA, SFERRAZZA, ALESSIO, CIAMMAICHELLA, ALINA, FERRIGNO, FEDERICA, PONZI, SIMONA, ONTORIA ONTORIA, JESUS MARIA
Year of Publication 18.02.2021
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Year of Publication 18.02.2021
Patent
SHP2 INHIBITORS
SFERRAZZA, Alessio, PONZI, Simona, ROSSETTI, Ilaria, FERRIGNO, Federica, ONTORIA ONTORIA, Jesus Maria, TORRENTE, Esther, PETROCCHI, Alessia, CIAMMAICHELLA, Alina
Year of Publication 18.02.2021
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Year of Publication 18.02.2021
Patent