Metabolite Identification via LC-SPE-NMR-MS of the In vitro Biooxidation Products of a Lead mGlu5 Allosteric Antagonist and Impact on the Improvement of Metabolic Stability in the Series
Ceccarelli, Simona M., Schlotterbeck, Götz, Boissin, Patrick, Binder, Martin, Buettelmann, Bernd, Hanlon, Steven, Jaeschke, Georg, Kolczewski, Sabine, Kupfer, Ernst, Peters, Jens-Uwe, Porter, Richard H. P., Prinssen, Eric P., Rueher, Marianne, Ruf, Iris, Spooren, Will, Stämpfli, Andreas, Vieira, Eric
Published in ChemMedChem (11.01.2008)
Published in ChemMedChem (11.01.2008)
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Journal Article
Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors
Kühne, Holger, Obst-Sander, Ulrike, Kuhn, Bernd, Conte, Aurelia, Ceccarelli, Simona M., Neidhart, Werner, Rudolph, Markus G., Ottaviani, Giorgio, Gasser, Rodolfo, So, Sung-Sau, Li, Shirley, Zhang, Xiaolei, Gao, Lin, Myers, Michael
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
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Journal Article
Rational design, synthesis, and structure–activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure
Ceccarelli, Simona M., Jaeschke, Georg, Buettelmann, Bernd, Huwyler, Jörg, Kolczewski, Sabine, Peters, Jens-Uwe, Prinssen, Eric, Porter, Richard, Spooren, Will, Vieira, Eric
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
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Journal Article
Discovery of N-(2-hydroxy-2-aryl-cyclohexyl) substituted spiropiperidines as GlyT1 antagonists with improved pharmacological profile
Ceccarelli, Simona M., Pinard, Emmanuel, Stalder, Henri, Alberati, Daniela
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
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Journal Article
Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists
Jaeschke, Georg, Porter, Richard, Büttelmann, Bernd, Ceccarelli, Simona M., Guba, Wolfgang, Kuhn, Bernd, Kolczewski, Sabine, Huwyler, Jörg, Mutel, Vincent, Peters, Jens-Uwe, Ballard, Theresa, Prinssen, Eric, Vieira, Eric, Wichmann, Jürgen, Spooren, Will
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
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Journal Article
Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: Achieving selectivity against the μ opioid and nociceptin/orphanin FQ peptide (NOP) receptors
Alberati, Daniela, Ceccarelli, Simona M., Jolidon, Synèse, Krafft, Eva A., Kurt, Anke, Maier, Axel, Pinard, Emmanuel, Stalder, Henri, Studer, Deborah, Thomas, Andrew W., Zimmerli, Daniel
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
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Journal Article
PIPERAZINO[1,2-A]INDOL-ONES AND [1, 4]DIAZEPINO[1,2-A]INDOL-1-ONE
JAGASIA, RAVI, CECCARELLI, SIMONA M, JAKOB-ROETNE, ROLAND, WICHMANN, JUERGEN
Year of Publication 30.04.2021
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Year of Publication 30.04.2021
Patent
BENZISOXAZOLE MODULATORS OF NEUROGENESIS
JAGASIA, RAVI, CECCARELLI, SIMONA M, JAKOB-ROETNE, ROLAND, WICHMANN, JUERGEN
Year of Publication 25.08.2020
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Year of Publication 25.08.2020
Patent
BENZIMIDAZOLES AS CNS ACTIVE AGENTS
JAGASIA, Ravi, WICHMANN, Juergen, CECCARELLI, Simona M, JAKOB-ROETNE, Roland
Year of Publication 19.07.2017
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Year of Publication 19.07.2017
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NEW ARYL-QUINOLINE DERIVATIVES
AURELIA CONTE, HOLGER KUEHNE, WERNER NEIDHART, MARKUS RUDOLPH, BERND KUHN, SIMONA M. CECCARELLI, ULRIKE OBST SANDER
Year of Publication 20.03.2019
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Year of Publication 20.03.2019
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Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one
Jagasia, Ravi, Jakob-Roetne, Roland, Wichmann, Juergen, Ceccarelli, Simona M
Year of Publication 30.03.2017
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Year of Publication 30.03.2017
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