Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1
Schoepfer, Joseph, Jahnke, Wolfgang, Berellini, Giuliano, Buonamici, Silvia, Cotesta, Simona, Cowan-Jacob, Sandra W, Dodd, Stephanie, Drueckes, Peter, Fabbro, Doriano, Gabriel, Tobias, Groell, Jean-Marc, Grotzfeld, Robert M, Hassan, A. Quamrul, Henry, Chrystèle, Iyer, Varsha, Jones, Darryl, Lombardo, Franco, Loo, Alice, Manley, Paul W, Pellé, Xavier, Rummel, Gabriele, Salem, Bahaa, Warmuth, Markus, Wylie, Andrew A, Zoller, Thomas, Marzinzik, Andreas L, Furet, Pascal
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
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BET bromodomain inhibitors regulate keratinocyte plasticity
Schutzius, Gabi, Kolter, Christian, Bergling, Sebastian, Tortelli, Federico, Fuchs, Florian, Renner, Steffen, Guagnano, Vito, Cotesta, Simona, Rueeger, Heinrich, Faller, Michael, Bouchez, Laure, Salathe, Adrian, Nigsch, Florian, Richards, Shola M., Louis, Malvina, Gruber, Viktoria, Aebi, Alexandra, Turner, Jonathan, Grandjean, Frederic, Li, Jun, Dimitri, Chris, Thomas, Jason R., Schirle, Markus, Blank, Jutta, Drueckes, Peter, Vaupel, Andrea, Tiedt, Ralph, Manley, Paul W., Klopp, Julia, Hemmig, Rene, Zink, Florence, Leroy, Nelly, Carbone, Walter, Roma, Guglielmo, Keller, Caroline Gubser, Dales, Natalie, Beyerbach, Armin, Zimmerlin, Alfred, Bonenfant, Debora, Terranova, Remi, Berwick, Amy, Sahambi, Sukhdeep, Reynolds, Aimee, Jennings, Lori L., Ruffner, Heinz, Tarsa, Peter, Bouwmeester, Tewis, Driver, Vickie, Frederiksen, Mathias, Lohmann, Felix, Kirkland, Susan
Published in Nature chemical biology (01.03.2021)
Published in Nature chemical biology (01.03.2021)
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High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines
Filipuzzi, Ireos, Cotesta, Simona, Perruccio, Francesca, Knapp, Britta, Fu, Yue, Studer, Christian, Pries, Verena, Riedl, Ralph, Helliwell, Stephen B, Petrovic, Katarina T, Movva, N Rao, Sanglard, Dominique, Tao, Jianshi, Hoepfner, Dominic
Published in PLoS genetics (17.11.2016)
Published in PLoS genetics (17.11.2016)
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Journal Article
Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery
Jahnke, Wolfgang, Rondeau, Jean-Michel, Cotesta, Simona, Marzinzik, Andreas, Pellé, Xavier, Geiser, Martin, Strauss, André, Götte, Marjo, Bitsch, Francis, Hemmig, René, Henry, Chrystèle, Lehmann, Sylvie, Glickman, J Fraser, Roddy, Thomas P, Stout, Steven J, Green, Jonathan R
Published in Nature chemical biology (01.09.2010)
Published in Nature chemical biology (01.09.2010)
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Journal Article
Binding or Bending: Distinction of Allosteric Abl Kinase Agonists from Antagonists by an NMR-Based Conformational Assay
Jahnke, Wolfgang, Grotzfeld, Robert M, Pellé, Xavier, Strauss, André, Fendrich, Gabriele, Cowan-Jacob, Sandra W, Cotesta, Simona, Fabbro, Doriano, Furet, Pascal, Mestan, Jürgen, Marzinzik, Andreas L
Published in Journal of the American Chemical Society (26.05.2010)
Published in Journal of the American Chemical Society (26.05.2010)
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Journal Article
Identification and Evaluation of Novel Acetolactate Synthase Inhibitors as Antifungal Agents
RICHIE, Daryl L, THOMPSON, Katherine V, DRUMM, Joseph, COTESTA, Simona, EICHENBERGER, Jürg, SCHUIERER, Sven, HARTMANN, Nicole, MOVVA, N. Rao, TALLARICO, John A, RYDER, Neil S, HOEPFNER, Dominic, STUDER, Christian, PRINDLE, Vivian C, AUST, Thomas, RIEDL, Ralph, ESTOPPEY, David, TAO, Jianshi, SEXTON, Jessica A, ZABAWA, Thomas
Published in Antimicrobial Agents and Chemotherapy (01.05.2013)
Published in Antimicrobial Agents and Chemotherapy (01.05.2013)
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Journal Article
Distinct effects of IPSU and suvorexant on mouse sleep architecture
Hoyer, Daniel, Dürst, Thomas, Fendt, Markus, Jacobson, Laura H, Betschart, Claudia, Hintermann, Samuel, Behnke, Dirk, Cotesta, Simona, Laue, Grit, Ofner, Silvio, Legangneux, Eric, Gee, Christine E
Published in Frontiers in neuroscience (01.01.2013)
Published in Frontiers in neuroscience (01.01.2013)
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Journal Article
Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors
Callander, Gabrielle E, Olorunda, Morenike, Monna, Dominique, Schuepbach, Edi, Langenegger, Daniel, Betschart, Claudia, Hintermann, Samuel, Behnke, Dirk, Cotesta, Simona, Fendt, Markus, Laue, Grit, Ofner, Silvio, Briard, Emmanuelle, Gee, Christine E, Jacobson, Laura H, Hoyer, Daniel
Published in Frontiers in neuroscience (01.01.2013)
Published in Frontiers in neuroscience (01.01.2013)
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Structural basis of species-selective antagonist binding to the succinate receptor
Haffke, Matthias, Fehlmann, Dominique, Rummel, Gabriele, Boivineau, Jacques, Duckely, Myriam, Gommermann, Nina, Cotesta, Simona, Sirockin, Finton, Freuler, Felix, Littlewood-Evans, Amanda, Kaupmann, Klemens, Jaakola, Veli-Pekka
Published in Nature (London) (01.10.2019)
Published in Nature (London) (01.10.2019)
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Journal Article
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C
Weiss, Andreas, Lorthiois, Edwige, Barys, Louise, Beyer, Kim S, Bomio-Confaglia, Claudio, Burks, Heather, Chen, Xueying, Cui, Xiaoming, de Kanter, Ruben, Dharmarajan, Lekshmi, Fedele, Carmine, Gerspacher, Marc, Guthy, Daniel Alexander, Head, Victoria, Jaeger, Ashley, Núñez, Eloísa Jiménez, Kearns, Jeffrey D, Leblanc, Catherine, Maira, Sauveur-Michel, Murphy, Jason, Oakman, Helen, Ostermann, Nils, Ottl, Johannes, Rigollier, Pascal, Roman, Danielle, Schnell, Christian, Sedrani, Richard, Shimizu, Toshio, Stringer, Rowan, Vaupel, Andrea, Voshol, Hans, Wessels, Peter, Widmer, Toni, Wilcken, Rainer, Xu, Kun, Zecri, Frederic, Farago, Anna F, Cotesta, Simona, Brachmann, Saskia M
Published in Cancer discovery (02.06.2022)
Published in Cancer discovery (02.06.2022)
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Journal Article
JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors
Lorthiois, Edwige, Gerspacher, Marc, Beyer, Kim S., Vaupel, Andrea, Leblanc, Catherine, Stringer, Rowan, Weiss, Andreas, Wilcken, Rainer, Guthy, Daniel A., Lingel, Andreas, Bomio-Confaglia, Claudio, Machauer, Rainer, Rigollier, Pascal, Ottl, Johannes, Arz, Dorothee, Bernet, Pascal, Desjonqueres, Gaëlle, Dussauge, Solene, Kazic-Legueux, Malika, Lozac’h, Marie-Anne, Mura, Christophe, Sorge, Mickaël, Todorov, Milen, Warin, Nicolas, Zink, Florence, Voshol, Hans, Zecri, Frederic J., Sedrani, Richard C., Ostermann, Nils, Brachmann, Saskia M., Cotesta, Simona
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
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Journal Article
Evolution of Novartis’ Small Molecule Screening Deck Design
Schuffenhauer, Ansgar, Schneider, Nadine, Hintermann, Samuel, Auld, Douglas, Blank, Jutta, Cotesta, Simona, Engeloch, Caroline, Fechner, Nikolas, Gaul, Christoph, Giovannoni, Jerome, Jansen, Johanna, Joslin, John, Krastel, Philipp, Lounkine, Eugen, Manchester, John, Monovich, Lauren G, Pelliccioli, Anna Paola, Schwarze, Manuel, Shultz, Michael D, Stiefl, Nikolaus, Baeschlin, Daniel K
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Journal Article
Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure
Velcicky, Juraj, Wilcken, Rainer, Cotesta, Simona, Janser, Philipp, Schlapbach, Achim, Wagner, Trixie, Piechon, Philippe, Villard, Frederic, Bouhelal, Rochdi, Piller, Fabian, Harlfinger, Stephanie, Stringer, Rowan, Fehlmann, Dominique, Kaupmann, Klemens, Littlewood-Evans, Amanda, Haffke, Matthias, Gommermann, Nina
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Journal Article
Abstract 14275: Allosteric Inhibition Restricts Motion of the SMURF1 Glycine Hinge and Reverses Experimental Pulmonary Arterial Hypertension
Rothman, Alex M, Florentin, Amir, Quigley, Catherine, Zink, Florence, Bonneau, Olivier, Hemming, Rene, Hachey, Amanda, Rejtar, Tomas, Thaker, Maulik, Jain, Rishi, Zhang, Ji-Hu, Cotesta, Simona, Ottl, Johannes, Kordinsky, Alina, Avishid, Reut, Troxler, Thomas, Binmahfooz, Sarah K, Morrell, Nicholas W, Humbert, Marc, Cobb, Jennifer, Osterman, Nils, Tallerico, John, Shaw, Duncan, Guth-Gundel, Sabine, Prag, Gali, Rowlands, David J
Published in Circulation (New York, N.Y.) (07.11.2023)
Published in Circulation (New York, N.Y.) (07.11.2023)
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Journal Article
Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture for the Treatment of Insomnia
Betschart, Claudia, Hintermann, Samuel, Behnke, Dirk, Cotesta, Simona, Fendt, Markus, Gee, Christine E, Jacobson, Laura H, Laue, Grit, Ofner, Silvio, Chaudhari, Vinod, Badiger, Sangamesh, Pandit, Chetan, Wagner, Juergen, Hoyer, Daniel
Published in Journal of medicinal chemistry (10.10.2013)
Published in Journal of medicinal chemistry (10.10.2013)
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Journal Article
Design and Synthesis of Inhibitors of the E3 Ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 as a Treatment for Lung Remodeling in Pulmonary Arterial Hypertension
Shaw, Duncan E., Smith, Nichola, Beerli, Rene, Cotesta, Simona, D’Alessandro, Pier-Luca, Edwards, Anne-Marie, Lattmann, Rene, Lizos, Dimitrios, Pulz, Robert, Rooney, Lisa, Sohal, Bindi, Rynn, Caroline, Taylor, Jessica, Troxler, Thomas, Williams, Gareth, Guth, Sabine, Rowlands, David
Published in Journal of medicinal chemistry (22.06.2023)
Published in Journal of medicinal chemistry (22.06.2023)
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Journal Article
Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin
Hoepfner, Dominic, McNamara, Case W., Lim, Chek Shik, Studer, Christian, Riedl, Ralph, Aust, Thomas, McCormack, Susan L., Plouffe, David M., Meister, Stephan, Schuierer, Sven, Plikat, Uwe, Hartmann, Nicole, Staedtler, Frank, Cotesta, Simona, Schmitt, Esther K., Petersen, Frank, Supek, Frantisek, Glynne, Richard J., Tallarico, John A., Porter, Jeffrey A., Fishman, Mark C., Bodenreider, Christophe, Diagana, Thierry T., Movva, N. Rao, Winzeler, Elizabeth A.
Published in Cell host & microbe (14.06.2012)
Published in Cell host & microbe (14.06.2012)
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Abstract P124: JDQ443, a covalent irreversible inhibitor of KRAS G12C, exhibits a novel binding mode and demonstrates potent anti-tumor activity and favorable pharmacokinetic properties in preclinical models
Brachmann, Saskia M., Weiss, Andreas, Guthy, Daniel A., Beyer, Kim, Voshol, Johannes, Maira, Michel, Prahallad, Anirudh, Porta, Diana Graus, Schnell, Christian, Ostermann, Nils, Vaupel, Andrea, Gerspacher, Marc, Leblanc, Catherine, Erdmann, Dirk, Sterker, Dario, Kerr, Grainne, Jerome, Giovannoni, Head, Victoria, Stringer, Rowan, De Kanter, Ruben, Jeff, Kearns, Roman, Danielle, Widmer, Toni, Wessels, Peter, Nunez, Eloisa Jimenez, Sedrani, Richard, Zecri, Frederic, Hofmann, Francesco, Engleman, Jeff, Lorthiois, Edwige, Cotesta, Simona
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS G12C for the Treatment of Solid Tumors
Lorthiois, Edwige, Gerspacher, Marc, Beyer, Kim S, Vaupel, Andrea, Leblanc, Catherine, Stringer, Rowan, Weiss, Andreas, Wilcken, Rainer, Guthy, Daniel A, Lingel, Andreas, Bomio-Confaglia, Claudio, Machauer, Rainer, Rigollier, Pascal, Ottl, Johannes, Arz, Dorothee, Bernet, Pascal, Desjonqueres, Gaëlle, Dussauge, Solene, Kazic-Legueux, Malika, Lozac'h, Marie-Anne, Mura, Christophe, Sorge, Mickaël, Todorov, Milen, Warin, Nicolas, Zink, Florence, Voshol, Hans, Zecri, Frederic J, Sedrani, Richard C, Ostermann, Nils, Brachmann, Saskia M, Cotesta, Simona
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
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Journal Article
Advantages and Challenges of Phenotypic Screens: The Identification of Two Novel Antifungal Geranylgeranyltransferase I Inhibitors
Pries, Verena, Cotesta, Simona, Riedl, Ralph, Aust, Thomas, Schuierer, Sven, Tao, Jianshi, Filipuzzi, Ireos, Hoepfner, Dominic
Published in Journal of biomolecular screening (01.03.2016)
Published in Journal of biomolecular screening (01.03.2016)
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