A novel pathway for amyloid precursor protein processing
Portelius, Erik, Price, Eric, Brinkmalm, Gunnar, Stiteler, Mark, Olsson, Maria, Persson, Rita, Westman-Brinkmalm, Ann, Zetterberg, Henrik, Simon, Adam J, Blennow, Kaj
Published in Neurobiology of aging (01.06.2011)
Published in Neurobiology of aging (01.06.2011)
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Evaluation of plasma proteomic data for Alzheimer disease state classification and for the prediction of progression from mild cognitive impairment to Alzheimer disease
Llano, Daniel A, Devanarayan, Viswanath, Simon, Adam J
Published in Alzheimer disease and associated disorders (01.07.2013)
Published in Alzheimer disease and associated disorders (01.07.2013)
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Machine learning for comprehensive forecasting of Alzheimer’s Disease progression
Fisher, Charles K., Smith, Aaron M., Walsh, Jonathan R.
Published in Scientific reports (20.09.2019)
Published in Scientific reports (20.09.2019)
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Regulation of Gene Expression by Lithium and Depletion of Inositol in Slices of Adult Rat Cortex
Brandish, Philip E., Su, Ming, Holder, Daniel J., Hodor, Paul, Szumiloski, John, Kleinhanz, Robert R., Forbes, Jaime E., McWhorter, Mollie E., Duenwald, Sven J., Parrish, Mark L., Na, Sang, Liu, Yuan, Phillips, Robert L., Renger, John J., Sankaranarayanan, Sethu, Simon, Adam J., Scolnick, Edward M.
Published in Neuron (Cambridge, Mass.) (24.03.2005)
Published in Neuron (Cambridge, Mass.) (24.03.2005)
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Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI
Shaw, Leslie M., Vanderstichele, Hugo, Knapik-Czajka, Malgorzata, Figurski, Michal, Coart, Els, Blennow, Kaj, Soares, Holly, Simon, Adam J., Lewczuk, Piotr, Dean, Robert A., Siemers, Eric, Potter, William, Lee, Virginia M.-Y., Trojanowski, John Q.
Published in Acta neuropathologica (01.05.2011)
Published in Acta neuropathologica (01.05.2011)
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Journal Article
Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors
Lindsley, Stacey R., Moore, Keith P., Rajapakse, Hemaka A., Selnick, Harold G., Young, Mary Beth, Zhu, Hong, Munshi, Sanjeev, Kuo, Lawrence, McGaughey, Georgia B., Colussi, Dennis, Crouthamel, Ming-Chih, Lai, Ming-Tain, Pietrak, Beth, Price, Eric A., Sankaranarayanan, Sethu, Simon, Adam J., Seabrook, Guy R., Hazuda, Daria J., Pudvah, Nicole T., Hochman, Jerome H., Graham, Samuel L., Vacca, Joseph P., Nantermet, Philippe G.
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
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Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1
Barrow, James C., Rittle, Kenneth E., Ngo, Phung L., Selnick, Harold G., Graham, Samuel L., Pitzenberger, Steven M., McGaughey, Georgia B., Colussi, Dennis, Lai, Ming-Tain, Huang, Qian, Tugusheva, Katherine, Espeseth, Amy S., Simon, Adam J., Munshi, Sanjeev K., Vacca, Joseph P.
Published in ChemMedChem (09.07.2007)
Published in ChemMedChem (09.07.2007)
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Persistent Replication of Hepatitis C Virus Replicons Expressing the β-Lactamase Reporter in Subpopulations of Highly Permissive Huh7 Cells
Murray, Edward M, Grobler, Jay A, Markel, Eric J, Pagnoni, Marco F, Paonessa, Giacomo, Simon, Adam J, Flores, Osvaldo A
Published in Journal of Virology (01.03.2003)
Published in Journal of Virology (01.03.2003)
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Biochemical and cell-based assays for characterization of BACE-1 inhibitors
Pietrak, Beth L., Crouthamel, Ming-Chih, Tugusheva, Katherine, Lineberger, Janet E., Xu, Min, DiMuzio, Jillian M., Steele, Thomas, Espeseth, Amy S., Stachel, Shawn J., Coburn, Craig A., Graham, Samuel L., Vacca, Joseph P., Shi, Xiao-Ping, Simon, Adam J., Hazuda, Daria J., Lai, Ming-Tain
Published in Analytical biochemistry (01.07.2005)
Published in Analytical biochemistry (01.07.2005)
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Identification of Resting and Active State EEG Features of Alzheimer’s Disease using Discrete Wavelet Transform
Ghorbanian, Parham, Devilbiss, David M., Verma, Ajay, Bernstein, Allan, Hess, Terry, Simon, Adam J., Ashrafiuon, Hashem
Published in Annals of biomedical engineering (01.06.2013)
Published in Annals of biomedical engineering (01.06.2013)
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Characterization of plasma β-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease
Wu, Guoxin, Sankaranarayanan, Sethu, Wong, Jacky, Tugusheva, Katherine, Michener, Maria S., Shi, Xiaoping, Cook, Jacquelynn J., Simon, Adam J., Savage, Mary J.
Published in Journal of neuroscience research (01.12.2012)
Published in Journal of neuroscience research (01.12.2012)
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Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers
Gandy, Sam, Simon, Adam J., Steele, John W., Lublin, Alex L., Lah, James J., Walker, Lary C., Levey, Allan I., Krafft, Grant A., Levy, Efrat, Checler, Frédéric, Glabe, Charles, Bilker, Warren B., Abel, Ted, Schmeidler, James, Ehrlich, Michelle E.
Published in Annals of neurology (01.08.2010)
Published in Annals of neurology (01.08.2010)
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Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound
Cook, Jacquelynn J, Wildsmith, Kristin R, Gilberto, David B, Holahan, Marie A, Kinney, Gene G, Mathers, Parker D, Michener, Maria S, Price, Eric A, Shearman, Mark S, Simon, Adam J, Wang, Jennifer X, Wu, Guoxin, Yarasheski, Kevin E, Bateman, Randall J
Published in The Journal of neuroscience (12.05.2010)
Published in The Journal of neuroscience (12.05.2010)
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First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates
Sankaranarayanan, Sethu, Holahan, Marie A, Colussi, Dennis, Crouthamel, Ming-Chih, Devanarayan, Viswanath, Ellis, Joan, Espeseth, Amy, Gates, Adam T, Graham, Samuel L, Gregro, Allison R, Hazuda, Daria, Hochman, Jerome H, Holloway, Katharine, Jin, Lixia, Kahana, Jason, Lai, Ming-tain, Lineberger, Janet, McGaughey, Georgia, Moore, Keith P, Nantermet, Philippe, Pietrak, Beth, Price, Eric A, Rajapakse, Hemaka, Stauffer, Shaun, Steinbeiser, Melissa A, Seabrook, Guy, Selnick, Harold G, Shi, Xiao-Ping, Stanton, Matthew G, Swestock, John, Tugusheva, Katherine, Tyler, Keala X, Vacca, Joseph P, Wong, Jacky, Wu, Guoxin, Xu, Min, Cook, Jacquelynn J, Simon, Adam J
Published in The Journal of pharmacology and experimental therapeutics (01.01.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2009)
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Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)
Stachel, Shawn J, Coburn, Craig A, Steele, Thomas G, Jones, Kristen G, Loutzenhiser, Elizabeth F, Gregro, Alison R, Rajapakse, Hemaka A, Lai, Ming-Tain, Crouthamel, Ming-Chih, Xu, Min, Tugusheva, Katherine, Lineberger, Janet E, Pietrak, Beth L, Espeseth, Amy S, Shi, Xiao-Ping, Chen-Dodson, Elizabeth, Holloway, M. Katharine, Munshi, Sanjeev, Simon, Adam J, Kuo, Lawrence, Vacca, Joseph P
Published in Journal of medicinal chemistry (16.12.2004)
Published in Journal of medicinal chemistry (16.12.2004)
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Effects of Exercise on EEG Activity and Standard Tools Used to Assess Concussion
Simon, Adam J., Kothare, Mayuresh V., Dussourd, Christopher R., Dunn, Emily, Etnoyer-Slaski, Jena L., Devilbiss, David M., Martino, Stephen J.
Published in Journal of healthcare engineering (01.01.2019)
Published in Journal of healthcare engineering (01.01.2019)
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Cisterna magna cannulated repeated CSF sampling rat model – effects of a gamma-secretase inhibitor on Aβ levels
Shapiro, Jennifer S., Stiteler, Mark, Wu, Guoxin, Price, Eric A., Simon, Adam J., Sankaranarayanan, Sethu
Published in Journal of neuroscience methods (30.03.2012)
Published in Journal of neuroscience methods (30.03.2012)
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