Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression
Simkin, Dina, Hattori, Shoai, Ybarra, Natividad, Musial, Timothy F, Buss, Eric W, Richter, Hannah, Oh, M Matthew, Nicholson, Daniel A, Disterhoft, John F
Published in The Journal of neuroscience (23.09.2015)
Published in The Journal of neuroscience (23.09.2015)
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Journal Article
Osteogenic and Chondrogenic Master Genes Expression Is Dependent on the Kir2.1 Potassium Channel Through the Bone Morphogenetic Protein Pathway
Pini, Jonathan, Giuliano, Serena, Matonti, Julia, Gannoun, Lila, Simkin, Dina, Rouleau, Matthieu, Bendahhou, Saïd
Published in Journal of bone and mineral research (01.10.2018)
Published in Journal of bone and mineral research (01.10.2018)
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Journal Article
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub
Forrest, Marc P., Dos Santos, Marc, Piguel, Nicolas H., Wang, Yi-Zhi, Hawkins, Nicole A., Bagchi, Vikram A., Dionisio, Leonardo E., Yoon, Sehyoun, Simkin, Dina, Martin-de-Saavedra, Maria Dolores, Gao, Ruoqi, Horan, Katherine E., George, Alfred L., LeDoux, Mark S., Kearney, Jennifer A., Savas, Jeffrey N., Penzes, Peter
Published in Nature communications (17.02.2023)
Published in Nature communications (17.02.2023)
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Journal Article
Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy
Simkin, Dina, Marshall, Kelly A, Vanoye, Carlos G, Desai, Reshma R, Bustos, Bernabe I, Piyevsky, Brandon N, Ortega, Juan A, Forrest, Marc, Robertson, Gabriella L, Penzes, Peter, Laux, Linda C, Lubbe, Steven J, Millichap, John J, George, Alfred L, Kiskinis, Evangelos
Published in eLife (05.02.2021)
Published in eLife (05.02.2021)
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Journal Article
Supramolecular Nanostructure Activates TrkB Receptor Signaling of Neuronal Cells by Mimicking Brain-Derived Neurotrophic Factor
Edelbrock, Alexandra N, Àlvarez, Zaida, Simkin, Dina, Fyrner, Timmy, Chin, Stacey M, Sato, Kohei, Kiskinis, Evangelos, Stupp, Samuel I
Published in Nano letters (10.10.2018)
Published in Nano letters (10.10.2018)
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Journal Article
Modeling Pediatric Epilepsy through iPSC-Based Technologies
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Book Review
Journal Article
19. Excitatory Dysfunction Drives Synchrony Deficits in a Schizophrenia 16p11.2 Duplication iPSC Derived Neuron Model
Parnell, Euan, Culotta, Lorenza, Forrest, Marc, Jalloul, Hiba, Eckman, Blair, Loizzo, Daniel, Santos, Marc Dos, Piguel, Nicolas, Tai, Derek, Zhang, Hanwen, Gertler, Tracy, Simkin, Dina, Sanders, Alan, Talkowski, Michael, Gejman, Pablo, Kiskinis, Evangelos, Duan, Jubao, Penzes, Peter
Published in Biological psychiatry (1969) (01.05.2023)
Published in Biological psychiatry (1969) (01.05.2023)
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Journal Article
'Channeling' therapeutic discovery for epileptic encephalopathy through iPSC technologies
Simkin, Dina, Ambrosi, Christina, Marshall, Kelly A, Williams, Luis A, Eisenberg, Jordyn, Gharib, Mennat, Dempsey, Graham T, George, Jr, Alfred L, McManus, Owen B, Kiskinis, Evangelos
Published in Trends in pharmacological sciences (Regular ed.) (01.05.2022)
Published in Trends in pharmacological sciences (Regular ed.) (01.05.2022)
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Journal Article
Excitatory Dysfunction Drives Network and Calcium Handling Deficits in 16p11.2 Duplication Schizophrenia Induced Pluripotent Stem Cell–Derived Neurons
Parnell, Euan, Culotta, Lorenza, Forrest, Marc P., Jalloul, Hiba A., Eckman, Blair L., Loizzo, Daniel D., Horan, Katherine K.E., Dos Santos, Marc, Piguel, Nicolas H., Tai, Derek J.C., Zhang, Hanwen, Gertler, Tracy S., Simkin, Dina, Sanders, Alan R., Talkowski, Michael E., Gejman, Pablo V., Kiskinis, Evangelos, Duan, Jubao, Penzes, Peter
Published in Biological psychiatry (1969) (15.07.2023)
Published in Biological psychiatry (1969) (15.07.2023)
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Journal Article
Andersen's syndrome mutants produce a knockdown of inwardly rectifying K.sup.+ channel in mouse skeletal muscle in vivo
Simkin, Dina, Robin, Gaëlle, Giuliano, Serena, Vukolic, Ana, Moceri, Pamela, Guy, Nicolas, Wagner, Kay-Dietrich
Published in Cell and tissue research (01.02.2018)
Published in Cell and tissue research (01.02.2018)
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Journal Article
Cognitive aging is associated with redistribution of synaptic weights in the hippocampus
Buss, Eric W., Corbett, Nicola J., Roberts, Joshua G., Ybarra, Natividad, Musial, Timothy F., Simkin, Dina, Molina-Campos, Elizabeth, Oh, Kwang-Jin, Nielsen, Lauren L., Ayala, Gelique D., Mullen, Sheila A., Farooqi, Anise K., D’Souza, Gary X., Hill, Corinne L., Bean, Linda A., Rogalsky, Annalise E., Russo, Matthew L., Curlik, Dani M., Antion, Marci D., Weiss, Craig, Chetkovich, Dane M., Oh, M. Matthew, Disterhoft, John F., Nicholson, Daniel A.
Published in Proceedings of the National Academy of Sciences - PNAS (23.02.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (23.02.2021)
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Journal Article
T124. Proteomic Profiling of the 16p11.2 Microduplication Mouse Model: Implications for Neuropsychiatric Disease
Forrest, Marc, Wang, Yi-Zhi, Piguel, Nicolas, Simkin, Dina, Hawkins, Nicole, Santos, Marc Dos, Dionisio, Leonardo, Bachi, Vikram, Kearney, Jennifer, Savas, Jeffrey, Penzes, Peter
Published in Biological psychiatry (1969) (15.05.2019)
Published in Biological psychiatry (1969) (15.05.2019)
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Journal Article
Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls
Simkin, Dina, Papakis, Vasileios, Bustos, Bernabe I., Ambrosi, Christina M., Ryan, Steven J., Baru, Valeriya, Williams, Luis A., Dempsey, Graham T., McManus, Owen B., Landers, John E., Lubbe, Steven J., George, Alfred L., Kiskinis, Evangelos
Published in Stem cell reports (12.04.2022)
Published in Stem cell reports (12.04.2022)
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Journal Article
Andersen’s syndrome mutants produce a knockdown of inwardly rectifying K+ channel in mouse skeletal muscle in vivo
Simkin, Dina, Robin, Gaëlle, Giuliano, Serena, Vukolic, Ana, Moceri, Pamela, Guy, Nicolas, Wagner, Kay-Dietrich, Lacampagne, Alain, Allard, Bruno, Bendahhou, Saïd
Published in Cell and tissue research (01.02.2018)
Published in Cell and tissue research (01.02.2018)
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Journal Article
Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression
Simkin, Dina, Hattori, Shoai, Ybarra, Natividad, Musial, Timothy F, Buss, Eric W, Richter, Hannah, Oh, M Matthew, Nicholson, Daniel A, Disterhoft, John F
Published in The Journal of neuroscience (03.09.2015)
Published in The Journal of neuroscience (03.09.2015)
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Journal Article