Anxiolytic- and Antidepressant-like Effects of the Non-Peptide Vasopressin V1b Receptor Antagonist, SSR149415, Suggest an Innovative Approach for the Treatment of Stress-Related Disorders
Griebel, Guy, Simiand, Jacques, Gal, Claudine Serradeil-Le, Wagnon, Jean, Pascal, Marc, Scatton, Bernard, Maffrand, Jean-Pierre, Soubrié, Philippe
Published in Proceedings of the National Academy of Sciences - PNAS (30.04.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (30.04.2002)
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4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine Hydrochloride (SSR125543A), a Potent and Selective Corticotrophin-Releasing Factor1 Receptor Antagonist. II. Characterization in Rodent Models of Stress-Related Disorders
Guy Griebel, Jacques Simiand, Régis Steinberg, Mireille Jung, Danielle Gully, Pierre Roger, Michel Geslin, Bernard Scatton, Jean-Pierre Maffrand, Philippe SoubriÃ
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
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Characterization of (2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a Selective and Orally Active Vasopressin V1b Receptor Antagonist
Serradeil-Le Gal, Claudine, Wagnon, Jean, Simiand, Jacques, Griebel, Guy, Lacour, Colette, Guillon, Gilles, Barberis, Claude, Brossard, Gabrielle, Soubrié, Philippe, Nisato, Dino, Pascal, Marc, Pruss, Rebecca, Scatton, Bernard, Maffrand, Jean-Pierre, Le Fur, Gérard
Published in The Journal of pharmacology and experimental therapeutics (01.03.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2002)
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Functional and Pharmacological Characterization of the First Specific Agonist and Antagonist for the V1b Receptor in Mammals
Claudine, Serradeil-Le Gal, Sylvain, Derick, Gabrielle, Brossard, Maurice, Manning, Jacques, Simiand, Rolf, Gaillard, Guy, Griebel, Gilles, Guillon
Published in Stress (Amsterdam, Netherlands) (01.09.2003)
Published in Stress (Amsterdam, Netherlands) (01.09.2003)
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4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine Hydrochloride (SSR125543A): A Potent and Selective Corticotrophin-Releasing Factor1 Receptor Antagonist. I. Biochemical and Pharmacological Characterization
Danielle Gully, Michel Geslin, Laurence Serva, Evelyne Fontaine, Pierre Roger, Christine Lair, Valerie Darre, Claudine Marcy, Pierre-Eric Rouby, Jacques Simiand, Josette Guitard, Georgette Gout, Regis Steinberg, Daniel Rodier, Guy Griebel, Philippe Soubrie, Marc Pascal, Rebecca Pruss, Bernard Scatton, Jean-Pierre Maffrand, Gerard Le Fur
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
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SSR240600 [(R)-2-(1-{2-[4-{2-[3,5-Bis(trifluoromethyl)phenyl]acetyl}-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl}-4-piperidinyl)-2-methylpropanamide], a Centrally Active Nonpeptide Antagonist of the Tachykinin Neurokinin 1 Receptor: II. Neurochemical and Behavioral Characterization
Steinberg, Régis, Alonso, Richard, Rouquier, Liliane, Desvignes, Christophe, Michaud, Jean-Claude, Cudennec, Annie, Jung, Mireille, Simiand, Jacques, Griebel, Guy, Emonds-Alt, Xavier, Le Fur, Gérard, Soubrié, Philippe
Published in The Journal of pharmacology and experimental therapeutics (01.12.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2002)
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Characterization of the profile of neurokinin-2 and neurotensin receptor antagonists in the mouse defense test battery
GRIEBEL, Guy, MOINDROT, Nicolas, ALIAGA, Carmen, SIMIAND, Jacques, SOUBRIE, Philippe
Published in Neuroscience and biobehavioral reviews (01.12.2001)
Published in Neuroscience and biobehavioral reviews (01.12.2001)
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Conference Proceeding
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SR146131: A New Potent, Orally Active, and Selective Nonpeptide Cholecystokinin Subtype 1 Receptor Agonist. II: In Vivo Pharmacological Characterization
Bignon, E, Alonso, R, Arnone, M, Boigegrain, R, Brodin, R, Gueudet, C, Héaulme, M, Keane, P, Landi, M, Molimard, J C, Olliero, D, Poncelet, M, Seban, E, Simiand, J, Soubrié, P, Pascal, M, Maffrand, J P, Le Fur, G
Published in The Journal of pharmacology and experimental therapeutics (01.05.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.05.1999)
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Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V 1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders
Griebel, Guy, Simiand, Jacques, Serradeil-Le Gal, Claudine, Wagnon, Jean, Pascal, Marc, Scatton, Bernard, Maffrand, Jean-Pierre, Soubrié, Philippe
Published in Proceedings of the National Academy of Sciences - PNAS (30.04.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (30.04.2002)
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Journal Article
4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine hydrochloride (SSR125543A), a potent and selective corticotrophin-releasing factor(1) receptor antagonist. II. Characterization in rodent models of stress-related disorders
Griebel, Guy, Simiand, Jacques, Steinberg, Régis, Jung, Mireille, Gully, Danielle, Roger, Pierre, Geslin, Michel, Scatton, Bernard, Maffrand, Jean-Pierre, Soubrié, Philippe
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
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Journal Article
4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A): a potent and selective corticotrophin-releasing factor(1) receptor antagonist. I. Biochemical and pharmacological characterization
Gully, Danielle, Geslin, Michel, Serva, Laurence, Fontaine, Evelyne, Roger, Pierre, Lair, Christine, Darre, Valerie, Marcy, Claudine, Rouby, Pierre-Eric, Simiand, Jacques, Guitard, Josette, Gout, Georgette, Steinberg, Regis, Rodier, Daniel, Griebel, Guy, Soubrie, Philippe, Pascal, Marc, Pruss, Rebecca, Scatton, Bernard, Maffrand, Jean-Pierre, Le Fur, Gerard
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
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Journal Article
Anxiolytic- and antidepressant-like effects of the non-pepetide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related
Griebel, Guy, Simiand, Jacques, Claudine Serradeil-Le Gal, Wagnon, Jean
Published in Proceedings of the National Academy of Sciences - PNAS (30.04.2002)
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Published in Proceedings of the National Academy of Sciences - PNAS (30.04.2002)
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SSR181507, a dopamine D2 receptor antagonist and 5-HT1A receptor agonist. II: Behavioral profile predictive of an atypical antipsychotic activity
DEPOORTERE, Ronan, BOULAY, Denis, PERRAULT, Ghislaine, BERGIS, Olivier, DECOBERT, Michel, FRANCON, Dominique, JUNG, Mireille, SIMIAND, Jacques, SOUBRIE, Philippe, SCATTON, Bernard
Published in Neuropsychopharmacology (New York, N.Y.) (01.11.2003)
Published in Neuropsychopharmacology (New York, N.Y.) (01.11.2003)
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Benzodiazepine impairs and beta-carboline enhances performance in learning and memory tasks
Venault, P, Chapouthier, G, de Carvalho, L P, Simiand, J, Morre, M, Dodd, R H, Rossier, J
Published in Nature (London) (26.06.1986)
Published in Nature (London) (26.06.1986)
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Journal Article
Up-regulation of 5-HT2 receptors in the rat brain by repeated administration of SR 46349B, a selective 5-HT2 receptor antagonist
RINALDI-CARMONA, M, MONSIF BOUABOULA, CONGY, C, OURY-DONAT, F, SIMIAND, J, SHIRE, D, CASELLAS, P, SOUBRIE, P, BRELIERE, J.-C, LE FUR, G
Published in European journal of pharmacology. Molecular pharmacology section (01.06.1993)
Published in European journal of pharmacology. Molecular pharmacology section (01.06.1993)
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4-(2-Chloro-4-methoxy-5-methylphenyl)- N -[(1 S )-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl- N -(2-propynyl)-1, 3-thiazol-2-amine Hydrochloride (SSR125543A), a Potent and Selective Corticotrophin-Releasing Factor 1 Receptor Antagonist. II. Characterization in Rodent Models of Stress-Related Disorders
Griebel, Guy, Simiand, Jacques, Steinberg, Régis, Jung, Mireille, Gully, Danielle, Roger, Pierre, Geslin, Michel, Scatton, Bernard, Maffrand, Jean-Pierre, Soubrié, Philippe
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
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Journal Article
Characterization of (2 S ,4 R )-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1 H -indol-3-yl]-4-hydroxy- N , N -dimethyl-2-pyrrolidine carboxamide (SSR149415), a Selective and Orally Active Vasopressin V 1b Receptor Antagonist
Gal, Claudine Serradeil-Le, Wagnon, Jean, Simiand, Jacques, Griebel, Guy, Lacour, Colette, Guillon, Gilles, Barberis, Claude, Brossard, Gabrielle, Soubrié, Philippe, Nisato, Dino, Pascal, Marc, Pruss, Rebecca, Scatton, Bernard, Maffrand, Jean-Pierre, Le Fur, Gérard
Published in The Journal of pharmacology and experimental therapeutics (01.03.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2002)
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SL651498: An Anxioselective Compound with Functional Selectivity for α2- and α3-Containing γ-Aminobutyric AcidA (GABAA) Receptors
Guy Griebel, Ghislaine Perrault, Jacques Simiand, Caroline Cohen, Patrick Granger, Michel Decobert, Dominique Françon, Patrick Avenet, Henri Depoortere, Suon Tan, André Oblin, Hans Schoemaker, Yannick Evanno, Mireille Sevrin, Pascal George, Bernard Scatton
Published in The Journal of pharmacology and experimental therapeutics (01.08.2001)
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Published in The Journal of pharmacology and experimental therapeutics (01.08.2001)
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