Antitumor Activity of BRAF Inhibitor Vemurafenib in Preclinical Models of BRAF-Mutant Colorectal Cancer
HONG YANG, HIGGINS, Brian, LESTINI, Brian, BOLLAG, Gideon, FEI SU, KOLINSKY, Kenneth, PACKMAN, Kathryn, BRADLEY, William D, LEE, Richard J, SCHOSTACK, Kathleen, ELLEN SIMCOX, Mary, KOPETZ, Scott, HEIMBROOK, David
Published in Cancer research (Chicago, Ill.) (01.02.2012)
Published in Cancer research (Chicago, Ill.) (01.02.2012)
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Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation
FEI SU, BRADLEY, William D, LEE, Richard J, SCHOSTACK, Kathleen, CARTER, Jade, ALBERT, Thomas, GERMER, Soren, ROSINSKI, Jim, MARTIN, Mitchell, ELLEN SIMCOX, Mary, LESTINI, Brian, HEIMBROOK, David, QIONGQING WANG, BOLLAG, Gideon, HONG YANG, LIZHONG XU, HIGGINS, Brian, KOLINSKY, Kenneth, PACKMAN, Kathryn, JUNG KIM, Min, TRUNZER, Kerstin
Published in Cancer research (Chicago, Ill.) (15.02.2012)
Published in Cancer research (Chicago, Ill.) (15.02.2012)
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A phase I monotherapy study of RG7212, a first-in-class monoclonal antibody targeting TWEAK signaling in patients with advanced cancers
Lassen, Ulrik N, Meulendijks, Didier, Siu, Lilian L, Karanikas, Vaios, Mau-Sorensen, Morten, Schellens, Jan H M, Jonker, Derek J, Hansen, Aaron R, Simcox, Mary E, Schostack, Kathleen J, Bottino, Dean, Zhong, Hua, Roessler, Markus, Vega-Harring, Suzana M, Jarutat, Tiantom, Geho, David, Wang, Ka, DeMario, Mark, Goss, Glenwood D
Published in Clinical cancer research (15.01.2015)
Published in Clinical cancer research (15.01.2015)
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Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors
Meulendijks, Didier, Lassen, Ulrik N, Siu, Lillian L, Huitema, Alwin D R, Karanikas, Vaios, Mau-Sorensen, Morten, Jonker, Derek J, Hansen, Aaron R, Simcox, Mary E, Schostack, Kathleen J, Bottino, Dean, Zhong, Hua, Roessler, Markus, Vega-Harring, Suzana M, Jarutat, Tiantom, Geho, David, Wang, Karen, DeMario, Mark, Goss, Glenwood D, Schellens, Jan H M
Published in Clinical cancer research (15.02.2016)
Published in Clinical cancer research (15.02.2016)
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RG7212 Anti-TWEAK mAb Inhibits Tumor Growth through Inhibition of Tumor Cell Proliferation and Survival Signaling and by Enhancing the Host Antitumor Immune Response
XUEFENG YIN, LUISTRO, Leopoldo, XIAOQIAN WANG, PACKMAN, Kathryn, ROSINSKI, Jim, BERKOFSKY-FESSLER, Windy, TANG, Jian-Ping, PANT, Saumya, GEHO, David, VEGA-HARRING, Suzana, DEMARIO, Mark, LEVITSKY, Hy, HUA ZHONG, SIMCOX, Mary, SMITH, Melissa, NEVINS, Tom, SCHOSTACK, Kathleen, HILTON, Holly, LIN, Tai-An, TRUITT, Theresa, BIONDI, Denise
Published in Clinical cancer research (15.10.2013)
Published in Clinical cancer research (15.10.2013)
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553 CUE-100 series Immuno-STATs from concept to the clinic: Leveraging protein engineering to stimulate and selectively deliver affinity-attenuated IL-2 to antigen-specific T cells
Histed, Alex, Girgis, Natasha, Moreta, Miguel, Soriano, Jonathan, Luke Witt, BS, Merazga, Zohra, Diaz, Fulvio, Zhao, Fan, Kemp, Melissa, Ruthardt, Paige, Thapa, Dharma, Suri, Anish, Seidel, Ronald, Pienta, Kenneth, Simcox, Mary, Quayle, Steven, Ross, John, Cemerski, Saso
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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RG7204 (PLX4032), a Selective BRAFV600E Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models
HONG YANG, HIGGINS, Brian, SCHOSTACK, Kathleen, SIMCOX, Mary Ellen, HEIMBROOK, David, BOLLAG, Gideon, FEI SU, KOLINSKY, Kenneth, PACKMAN, Kathryn, ZENAIDA GO, IYER, Raman, KOLIS, Stanley, ZHAO, Sylvia, LEE, Richard, GRIPPO, Joseph F
Published in Cancer research (Chicago, Ill.) (01.07.2010)
Published in Cancer research (Chicago, Ill.) (01.07.2010)
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CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies
Quayle, Steven N, Girgis, Natasha, Thapa, Dharma R, Merazga, Zohra, Kemp, Melissa M, Histed, Alex, Zhao, Fan, Moreta, Miguel, Ruthardt, Paige, Hulot, Sandrine, Nelson, Alyssa, Kraemer, Lauren D, Beal, Dominic R, Witt, Luke, Ryabin, Jessica, Soriano, Jonathan, Haydock, Mark, Spaulding, Emily, Ross, John F, Kiener, Peter A, Almo, Steven, Chaparro, Rodolfo, Seidel, Ronald, Suri, Anish, Cemerski, Saso, Pienta, Kenneth J, Simcox, Mary Ellen
Published in Clinical cancer research (15.04.2020)
Published in Clinical cancer research (15.04.2020)
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3,5,6-Trisubstituted naphthostyrils as CDK2 inhibitors
Liu, Jin-Jun, Dermatakis, Apostolos, Lukacs, Christine, Konzelmann, Fred, Chen, Yi, Kammlott, Ursula, Depinto, Wanda, Yang, Hong, Yin, Xuefeng, Chen, Yingsi, Schutt, Andy, Simcox, Mary Ellen, Luk, Kin-Chun
Published in Bioorganic & medicinal chemistry letters (04.08.2003)
Published in Bioorganic & medicinal chemistry letters (04.08.2003)
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Abstract 39: Discovery of PEN-221, an SSTR2-targeting maytansinoid conjugate with potent activity in vitro and in vivo
White, Brian H., Bazinet, Patrick, Whalen, Kerry, DuPont, Michelle, Quinn, James M., Alargova, Rossitza, Yeung, Tsun Au, Brockman, Adam, Gifford, James, Oller, Haley, Kriksciukaite, Kristina, Lemelin, Charles-Andre, Soo, Patrick Lim, Moreau, Benoit, Perino, Samantha, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Simcox, Mary, Wooster, Richard, Bilodeau, Mark T.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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표적 치료제를 포함하는 병용 요법
BILODEAU MARK T, KADIYALA SUDHAKAR, ALLAND LEILA, PERINO SAMANTHA, WOOSTER RICHARD, SIMCOX MARY, WHALEN KERRY
Year of Publication 17.02.2020
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Year of Publication 17.02.2020
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Gene expression analysis in biomarker research and early drug development using function tested reverse transcription quantitative real-time PCR assays
Lohmann, Sabine, Herold, Andrea, Bergauer, Tobias, Belousov, Anton, Betzl, Gisela, Demario, Mark, Dietrich, Manuel, Luistro, Leopoldo, Poignée-Heger, Manuela, Schostack, Kathy, Simcox, Mary, Walch, Heiko, Yin, Xuefeng, Zhong, Hua, Weisser, Martin
Published in Methods (San Diego, Calif.) (01.01.2013)
Published in Methods (San Diego, Calif.) (01.01.2013)
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354 A phase 1 trial of CUE-101 a novel HPV16 E7-pHLA-IL2-Fc fusion protein in patients with recurrent/metastatic HPV16+ head and neck cancer
Pai, Sara, Adkins, Douglas, Wirth, Lori, Chung, Christine, Gibson, Michael, Ammar Sukari, Worden, Francis, Colevas, Dimitrios, Saba, Nabil, Burtness, Barbara, Rodriguez, Cristina, Bauman, Julie, Glisson, Bonnie, Dunn, Lara, Suri, Anish, Haydock, Mark, Quayle, Steven, Cemerski, Saso, Leader, Megan, Brown, Jason, Pienta, Kenneth, Simcox, Mary
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Abstract 1370: RO5323441, a humanized monoclonal antibody against the placenta growth factor, blocks PlGF-induced VEGFR-1 phosphorylation in vitro and tumor growth in vivo
Rizzo, Christine, Yin, Xuefeng Yin, Packman, Kathryn, Higgins, Brian, Schnueriger, Alfred, Thomas, Markus, Weidner, Michael, Heimbrook, Dave, Simcox, Mary Ellen C.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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A new series of potent oxindole inhibitors of CDK2
LUK, Kin-Chun, SIMCOX, Mary Ellen, SCHUTT, Andy, ROWAN, Karen, THOMPSON, Thelma, YI CHEN, KAMMLOTT, Ursula, DEPINTO, Wanda, DUNTEN, Pete, DERMATAKIS, Apos
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
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RO4383596, an orally active KDR, FGFR, and PDGFR inhibitor: Synthesis and biological evaluation
McDermott, Lee A., Simcox, Mary, Higgins, Brian, Nevins, Tom, Kolinsky, Kenneth, Smith, Melissa, Yang, Hong, Li, Jia K., Chen, Yingsi, Ke, June, Mallalieu, Navita, Egan, Tom, Kolis, Stan, Railkar, Aruna, Gerber, Louise, Luk, Kin-Chun
Published in Bioorganic & medicinal chemistry (15.08.2005)
Published in Bioorganic & medicinal chemistry (15.08.2005)
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Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis
McDermott, Lee A., Higgins, Brian, Simcox, Mary, Luk, Kin-Chun, Nevins, Tom, Kolinsky, Kenneth, Smith, Melissa, Yang, Hong, Li, Jia K., Chen, Yingsi, Ke, June, Mallalieu, Navita, Egan, Tom, Kolis, Stan, Railkar, Aruna, Gerber, Louise, Liu, Jin-Jun, Konzelmann, Fred, Zhang, Zhuming, Flynn, Tom, Morales, Omar, Chen, Yi
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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HSP90-TARGETING CONJUGATES AND FORMULATIONS THEREOF
Bilodeau, Mark T, White, Brian H, Whalen, Kerry, Shinde, Rajesh R, Moreau, Benoît, Wooster, Richard, Simcox, Mary, Alland, Leila
Year of Publication 31.03.2022
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Year of Publication 31.03.2022
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HSP90-targeting conjugates and formulations thereof
Bilodeau, Mark T, White, Brian H, Whalen, Kerry, Shinde, Rajesh R, Moreau, Benoît, Wooster, Richard, Simcox, Mary, Alland, Leila
Year of Publication 08.02.2022
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Year of Publication 08.02.2022
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COMBINATION THERAPIES COMPRISING TARGETED THERAPEUTICS
ALLAND, Leila, BILODEAU, Mark T, KADIYALA, Sudhakar, PERINO, Samantha, WOOSTER, Richard, WHALEN, Kerry, SIMCOX, Mary
Year of Publication 10.03.2021
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Year of Publication 10.03.2021
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