ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis
Ma, Bin, Marcotte, Doug, Paramasivam, Murugan, Michelsen, Klaus, Wang, Ti, Bertolotti-Ciarlet, Andrea, Jones, John Howard, Moree, Ben, Butko, Margaret, Salafsky, Joshua, Sun, Xin, McKee, Timothy, Silvian, Laura F
Published in PloS one (10.11.2016)
Published in PloS one (10.11.2016)
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Journal Article
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism
Marcotte, Douglas, Zeng, Weike, Hus, Jean-Christophe, McKenzie, Andres, Hession, Cathy, Jin, Ping, Bergeron, Chris, Lugovskoy, Alexey, Enyedy, Istvan, Cuervo, Hernan, Wang, Deping, Atmanene, Cédric, Roecklin, Dominique, Vecchi, Malgorzata, Vivat, Valérie, Kraemer, Joachim, Winkler, Dirk, Hong, Victor, Chao, Jianhua, Lukashev, Matvey, Silvian, Laura
Published in Bioorganic & medicinal chemistry (15.07.2013)
Published in Bioorganic & medicinal chemistry (15.07.2013)
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Journal Article
Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model
Vandeveer, George H., Arduini, Robert M., Baker, Darren P., Barry, Kevin, Bohnert, Tonika, Bowden-Verhoek, Jon K., Conlon, Patrick, Cullen, Patrick F., Guan, Bing, Jenkins, Tracy J., Liao, Shu-Yu, Lin, Lin, Liu, Yu-Ting, Marcotte, Douglas, Mertsching, Elisabeth, Metrick, Claire M., Negrou, Ella, Powell, Noel, Scott, Daniel, Silvian, Laura F., Hopkins, Brian T.
Published in Bioorganic & medicinal chemistry letters (15.01.2023)
Published in Bioorganic & medicinal chemistry letters (15.01.2023)
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Journal Article
Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases
Marcotte, Douglas J., Liu, Yu‐Ting, Arduini, Robert M., Hession, Catherine A., Miatkowski, Konrad, Wildes, Craig P., Cullen, Patrick F., Hong, Victor, Hopkins, Brian T., Mertsching, Elisabeth, Jenkins, Tracy J., Romanowski, Michael J., Baker, Darren P., Silvian, Laura F.
Published in Protein science (01.03.2010)
Published in Protein science (01.03.2010)
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Journal Article
Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine‐based inhibitor co‐crystal structure
Marcotte, Douglas J., Hus, Jean‐Christophe, Banos, Charles C., Wildes, Craig, Arduini, Robert, Bergeron, Chris, Hession, Catherine A., Baker, Darren P., Lin, Edward, Guckian, Kevin M., Dunah, Anthone W., Silvian, Laura F.
Published in Protein science (01.03.2018)
Published in Protein science (01.03.2018)
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Journal Article
Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction
Lin, Edward Y S, Silvian, Laura F, Marcotte, Douglas J, Banos, Charles C, Jow, Flora, Chan, Timothy R, Arduini, Robert M, Qian, Fang, Baker, Darren P, Bergeron, Chris, Hession, Catherine A, Huganir, Richard L, Borenstein, Cassandra F, Enyedy, Istvan, Zou, Jinming, Rohde, Ellen, Wittmann, Marion, Kumaravel, Gnanasambandam, Rhodes, Kenneth J, Scannevin, Robert H, Dunah, Anthone W, Guckian, Kevin M
Published in Scientific reports (07.09.2018)
Published in Scientific reports (07.09.2018)
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Improving the solubility of anti‐LINGO‐1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis
Pepinsky, R. Blake, Silvian, Laura, Berkowitz, Steven A., Farrington, Graham, Lugovskoy, Alexey, Walus, Lee, Eldredge, John, Capili, Allan, Mi, Sha, Graff, Christilyn, Garber, Ellen
Published in Protein science (01.05.2010)
Published in Protein science (01.05.2010)
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Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase
Shlevkov, Evgeny, Murugan, Paramasivam, Montagna, Dan, Stefan, Eric, Hadzipasic, Adelajda, Harvey, James S., Kumar, P. Rajesh, Entova, Sonya, Bansal, Nupur, Bickford, Shari, Wong, Lai-Yee, Hirst, Warren D., Weihofen, Andreas, Silvian, Laura F.
Published in iScience (21.01.2022)
Published in iScience (21.01.2022)
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Journal Article
Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand
Marcotte, Douglas J, Liu, YuTing, Little, Kevin, Jones, John H, Powell, Noel A, Wildes, Craig P, Silvian, Laura F, Chodaparambil, Jayanth V
Published in BMC structural biology (01.06.2016)
Published in BMC structural biology (01.06.2016)
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Journal Article
Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site
Rushe, Mia, Silvian, Laura, Bixler, Sarah, Chen, Ling Ling, Cheung, Anne, Bowes, Scott, Cuervo, Hernan, Berkowitz, Steven, Zheng, Timothy, Guckian, Kevin, Pellegrini, Maria, Lugovskoy, Alexey
Published in Structure (London) (01.05.2008)
Published in Structure (London) (01.05.2008)
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Journal Article
Germinal‐center kinase‐like kinase co‐crystal structure reveals a swapped activation loop and C‐terminal extension
Marcotte, Douglas, Rushe, Mia, M. Arduini, Robert, Lukacs, Christine, Atkins, Kateri, Sun, Xin, Little, Kevin, Cullivan, Michael, Paramasivam, Murugan, Patterson, Thomas A., Hesson, Thomas, D. McKee, Timothy, May‐Dracka, Tricia L., Xin, Zhili, Bertolotti‐Ciarlet, Andrea, Bhisetti, Govinda R., Lyssikatos, Joseph P., Silvian, Laura F.
Published in Protein science (01.02.2017)
Published in Protein science (01.02.2017)
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Journal Article
Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism
Silvian, Laura F, Friedman, Jessica E, Strauch, Kathy, Cachero, Teresa G, Day, Eric S, Qian, Fang, Cunningham, Brian, Fung, Amy, Sun, Lihong, Su, Lihe, Zheng, Zhongli, Kumaravel, Gnanasambandam, Whitty, Adrian
Published in ACS chemical biology (17.06.2011)
Published in ACS chemical biology (17.06.2011)
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Formation of Virus-like Clusters Is an Intrinsic Property of the Tumor Necrosis Factor Family Member BAFF (B Cell Activating Factor)
Cachero, Teresa G, Schwartz, Ian M, Qian, Fang, Day, Eric S, Bossen, Claudia, Ingold, Karine, Tardivel, Aubry, Krushinskie, Dennis, Eldredge, John, Silvian, Laura, Lugovskoy, Alexey, Farrington, Graham K, Strauch, Kathy, Schneider, Pascal, Whitty, Adrian
Published in Biochemistry (Easton) (21.02.2006)
Published in Biochemistry (Easton) (21.02.2006)
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A Neutralizing Anti-Nogo66 Receptor Monoclonal Antibody Reverses Inhibition of Neurite Outgrowth by Central Nervous System Myelin
Li, Weiwei, Walus, Lee, Rabacchi, Sylvia A, Jirik, Adrienna, Chang, Ernie, Schauer, Jessica, Zheng, Betty H, Benedetti, Nancy J, Liu, Betty P, Choi, Eugene, Worley, Dane, Silvian, Laura, Mo, Wenjun, Mullen, Colleen, Yang, Weixing, Strittmatter, Stephen M, Sah, Dinah W Y, Pepinsky, Blake, Lee, Daniel H S
Published in The Journal of biological chemistry (15.10.2004)
Published in The Journal of biological chemistry (15.10.2004)
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Journal Article
Correction to Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism
Silvian, Laura F, Friedman, Jessica E, Strauch, Kathy, Cachero, Teresa G, Day, Eric S, Qian, Fang, Cunningham, Brian, Fung, Amy, Sun, Lihong, Shipps, Gerald W, Su, Lihe, Zheng, Zhongli, Kumaravel, Gnanasambandam, Whitty, Adrian
Published in ACS chemical biology (15.07.2011)
Published in ACS chemical biology (15.07.2011)
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Journal Article
How glutaminyl-tRNA synthetase selects glutamine
Rath, Virginia L, Silvian, Laura F, Beijer, Barbro, Sproat, Brian S, Steitz, Thomas A
Published in Structure (London) (15.04.1998)
Published in Structure (London) (15.04.1998)
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