Janus kinases to jakinibs: from basic insights to clinical practice
Gadina, Massimo, Le, Mimi T, Schwartz, Daniella M, Silvennoinen, Olli, Nakayamada, Shingo, Yamaoka, Kunihiro, O'Shea, John J
Published in Rheumatology (Oxford, England) (01.02.2019)
Published in Rheumatology (Oxford, England) (01.02.2019)
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Journal Article
ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
Hammarén, Henrik M., Ungureanu, Daniela, Grisouard, Jean, Skoda, Radek C., Hubbard, Stevan R., Silvennoinen, Olli
Published in Proceedings of the National Academy of Sciences - PNAS (14.04.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (14.04.2015)
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Journal Article
Editorial: JAK inhibition in autoimmune and inflammatory diseases
Telliez, Jean-Baptiste, Gadina, Massimo, Ghoreschi, Kamran, Silvennoinen, Olli, Spinelli, Francesca Romana
Published in Frontiers in immunology (28.12.2022)
Published in Frontiers in immunology (28.12.2022)
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Journal Article
Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates With Treatment Response
Palmroth, Maaria, Kuuliala, Krista, Peltomaa, Ritva, Virtanen, Anniina, Kuuliala, Antti, Kurttila, Antti, Kinnunen, Anna, Leirisalo-Repo, Marjatta, Silvennoinen, Olli, Isomäki, Pia
Published in Frontiers in immunology (24.09.2021)
Published in Frontiers in immunology (24.09.2021)
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Journal Article
Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture
Lahti, Anna L, Kujala, Ville J, Chapman, Hugh, Koivisto, Ari-Pekka, Pekkanen-Mattila, Mari, Kerkelä, Erja, Hyttinen, Jari, Kontula, Kimmo, Swan, Heikki, Conklin, Bruce R, Yamanaka, Shinya, Silvennoinen, Olli, Aalto-Setälä, Katriina
Published in Disease models & mechanisms (01.03.2012)
Published in Disease models & mechanisms (01.03.2012)
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Journal Article
An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation
Saarimäki-Vire, Jonna, Balboa, Diego, Russell, Mark A., Saarikettu, Juha, Kinnunen, Matias, Keskitalo, Salla, Malhi, Amrinder, Valensisi, Cristina, Andrus, Colin, Eurola, Solja, Grym, Heli, Ustinov, Jarkko, Wartiovaara, Kirmo, Hawkins, R. David, Silvennoinen, Olli, Varjosalo, Markku, Morgan, Noel G., Otonkoski, Timo
Published in Cell reports (Cambridge) (11.04.2017)
Published in Cell reports (Cambridge) (11.04.2017)
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Journal Article
Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations
Kujala, Kirsi, Paavola, Jere, Lahti, Anna, Larsson, Kim, Pekkanen-Mattila, Mari, Viitasalo, Matti, Lahtinen, Annukka M, Toivonen, Lauri, Kontula, Kimmo, Swan, Heikki, Laine, Mika, Silvennoinen, Olli, Aalto-Setälä, Katriina
Published in PloS one (04.09.2012)
Published in PloS one (04.09.2012)
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Journal Article
Development of an enzyme-coupled activity assay for Janus kinase 2 inhibitor screening
Pölläniemi, Angelika, Virtanen, Anniina, Silvennoinen, Olli, Haikarainen, Teemu
Published in SLAS discovery (01.06.2023)
Published in SLAS discovery (01.06.2023)
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Journal Article
Friend or Foe? The fascinating Tudor-SN protein
Gao, Xingjie, Xin, Lingbiao, Yao, Zhi, Silvennoinen, Olli, Yang, Jie
Published in Visualized cancer medicine (2023)
Published in Visualized cancer medicine (2023)
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Journal Article
Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain
Virtanen, Anniina T, Haikarainen, Teemu, Sampathkumar, Parthasarathy, Palmroth, Maaria, Liukkonen, Sanna, Liu, Jianping, Nekhotiaeva, Natalia, Hubbard, Stevan R, Silvennoinen, Olli
Published in Pharmaceuticals (Basel, Switzerland) (01.01.2023)
Published in Pharmaceuticals (Basel, Switzerland) (01.01.2023)
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Journal Article
Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain
Saharinen, Pipsa, Vihinen, Mauno, Silvennoinen, Olli
Published in Molecular biology of the cell (01.04.2003)
Published in Molecular biology of the cell (01.04.2003)
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Journal Article
Regulation of the Jak2 Tyrosine Kinase by Its Pseudokinase Domain
Saharinen, Pipsa, Takaluoma, Kati, Silvennoinen, Olli
Published in Molecular and Cellular Biology (01.05.2000)
Published in Molecular and Cellular Biology (01.05.2000)
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Journal Article
Poly(A)+ mRNA‐binding protein Tudor‐SN regulates stress granules aggregation dynamics
Gao, Xingjie, Fu, Xue, Song, Juan, Zhang, Yi, Cui, Xiaoteng, Su, Chao, Ge, Lin, Shao, Jie, Xin, Lingbiao, Saarikettu, Juha, Mei, Mei, Yang, Xi, Wei, Minxin, Silvennoinen, Olli, Yao, Zhi, He, Jinyan, Yang, Jie
Published in The FEBS journal (01.03.2015)
Published in The FEBS journal (01.03.2015)
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Journal Article
IRF2BP2 Mutation Is Associated with Increased STAT1 and STAT5 Activation in Two Family Members with Inflammatory Conditions and Lymphopenia
Palmroth, Maaria, Viskari, Hanna, Seppänen, Mikko R. J., Keskitalo, Salla, Virtanen, Anniina, Varjosalo, Markku, Silvennoinen, Olli, Isomäki, Pia
Published in Pharmaceuticals (Basel, Switzerland) (13.08.2021)
Published in Pharmaceuticals (Basel, Switzerland) (13.08.2021)
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Journal Article