Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability
Goldenzweig, Adi, Goldsmith, Moshe, Hill, Shannon E., Gertman, Or, Laurino, Paola, Ashani, Yacov, Dym, Orly, Unger, Tamar, Albeck, Shira, Prilusky, Jaime, Lieberman, Raquel L., Aharoni, Amir, Silman, Israel, Sussman, Joel L., Tawfik, Dan S., Fleishman, Sarel J.
Published in Molecular cell (21.07.2016)
Published in Molecular cell (21.07.2016)
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Journal Article
Function and structure of inherently disordered proteins
Dunker, A Keith, Silman, Israel, Uversky, Vladimir N, Sussman, Joel L
Published in Current opinion in structural biology (01.12.2008)
Published in Current opinion in structural biology (01.12.2008)
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Journal Article
Computational Studies on Acetylcholinesterases
Xu, Yechun, Cheng, Shanmei, Sussman, Joel L, Silman, Israel, Jiang, Hualiang
Published in Molecules (Basel, Switzerland) (10.08.2017)
Published in Molecules (Basel, Switzerland) (10.08.2017)
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Journal Article
A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides
Nachon, Florian, Rosenberry, Terrone L, Silman, Israel, Sussman, Joel L
Published in Molecules (Basel, Switzerland) (06.03.2020)
Published in Molecules (Basel, Switzerland) (06.03.2020)
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Journal Article
Directed evolution of hydrolases for prevention of G-type nerve agent intoxication
Tawfik, Dan S, Gupta, Rinkoo D, Goldsmith, Moshe, Ashani, Yacov, Simo, Yair, Mullokandov, Gavriel, Bar, Hagit, Ben-David, Moshe, Leader, Haim, Margalit, Raanan, Silman, Israel, Sussman, Joel L
Published in Nature chemical biology (01.02.2011)
Published in Nature chemical biology (01.02.2011)
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Journal Article
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis
Khare, Sagar D, Kipnis, Yakov, Greisen, Per Jr, Takeuchi, Ryo, Ashani, Yacov, Goldsmith, Moshe, Song, Yifan, Gallaher, Jasmine L, Silman, Israel, Leader, Haim, Sussman, Joel L, Stoddard, Barry L, Tawfik, Dan S, Baker, David
Published in Nature chemical biology (05.02.2012)
Published in Nature chemical biology (05.02.2012)
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Journal Article
Context‐dependent resistance to proteolysis of intrinsically disordered proteins
Suskiewicz, Marcin J., Sussman, Joel L., Silman, Israel, Shaul, Yosef
Published in Protein science (01.08.2011)
Published in Protein science (01.08.2011)
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Journal Article
Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis
Galdeano, Carles, Coquelle, Nicolas, Cieslikiewicz-Bouet, Monika, Bartolini, Manuela, Pérez, Belén, Clos, M Victòria, Silman, Israel, Jean, Ludovic, Colletier, Jacques-Philippe, Renard, Pierre-Yves, Muñoz-Torrero, Diego
Published in Molecules (Basel, Switzerland) (11.03.2018)
Published in Molecules (Basel, Switzerland) (11.03.2018)
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Journal Article
Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability
Goldenzweig, Adi, Goldsmith, Moshe, Hill, Shannon E., Gertman, Or, Laurino, Paola, Ashani, Yacov, Dym, Orly, Unger, Tamar, Albeck, Shira, Prilusky, Jaime, Lieberman, Raquel L., Aharoni, Amir, Silman, Israel, Sussman, Joel L., Tawfik, Dan S., Fleishman, Sarel J.
Published in Molecular cell (19.04.2018)
Published in Molecular cell (19.04.2018)
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Journal Article
Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes
Sussman, Joel L, Tawfik, Dan S, Harel, Michal, Aharoni, Amir, Gaidukov, Leonid, Brumshtein, Boris, Khersonsky, Olga, Meged, Ran, Dvir, Hay, Ravelli, Raimond B G, McCarthy, Andrew, Toker, Lilly, Silman, Israel
Published in Nature structural & molecular biology (01.05.2004)
Published in Nature structural & molecular biology (01.05.2004)
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Journal Article
Directed Evolution of Mammalian Paraoxonases PON1 and PON3 for Bacterial Expression and Catalytic Specialization
Aharoni, Amir, Gaidukov, Leonid, Yagur, Shai, Toker, Lilly, Silman, Israel, Tawfik, Dan S.
Published in Proceedings of the National Academy of Sciences - PNAS (13.01.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (13.01.2004)
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Journal Article
Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome
Tsvetkov, Peter, Asher, Gad, Paz, Aviv, Reuven, Nina, Sussman, Joel L., Silman, Israel, Shaul, Yosef
Published in Proteins, structure, function, and bioinformatics (01.03.2008)
Published in Proteins, structure, function, and bioinformatics (01.03.2008)
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Journal Article
Shoot-and-Trap: Use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography
Colletier, Jacques-Philippe, Bourgeois, Dominique, Sanson, Benoît, Fournier, Didier, Sussman, Joel L, Silman, Israel, Weik, Martin
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2008)
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Journal Article
Rivastigmine and metabolite analogues with putative Alzheimer’s disease-modifying properties in a Caenorhabditis elegans model
Dighe, Satish N., De la Mora, Eugenio, Chan, Stephen, Kantham, Srinivas, McColl, Gawain, Miles, Jared A., Veliyath, Suresh Kumar, Sreenivas, B. Yogi, Nassar, Zeyad D., Silman, Israel, Sussman, Joel L., Weik, Martin, McGeary, Ross P., Parat, Marie-Odile, Brazzolotto, Xavier, Ross, Benjamin P.
Published in Communications chemistry (22.03.2019)
Published in Communications chemistry (22.03.2019)
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Journal Article
Specific Chemical and Structural Damage to Proteins Produced by Synchrotron Radiation
Weik, Martin, Raimond B. G. Ravelli, Kryger, Gitay, McSweeney, Sean, Raves, Maria L., Harel, Michal, Gros, Piet, Silman, Israel, Kroon, Jan, Sussman, Joel L.
Published in Proceedings of the National Academy of Sciences - PNAS (18.01.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (18.01.2000)
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Journal Article
Induced‐fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure‐based drug design
Xu, Yechun, Colletier, Jacques Ph, Jiang, Hualiang, Silman, Israel, Sussman, Joel L., Weik, Martin
Published in Protein science (01.04.2008)
Published in Protein science (01.04.2008)
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