2-Aminothiazoles as Therapeutic Leads for Prion Diseases
Gallardo-Godoy, Alejandra, Gever, Joel, Fife, Kimberly L, Silber, B. Michael, Prusiner, Stanley B, Renslo, Adam R
Published in Journal of medicinal chemistry (24.02.2011)
Published in Journal of medicinal chemistry (24.02.2011)
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Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains
Giles, Kurt, Berry, David B, Condello, Carlo, Hawley, Ronald C, Gallardo-Godoy, Alejandra, Bryant, Clifford, Oehler, Abby, Elepano, Manuel, Bhardwaj, Sumita, Patel, Smita, Silber, B Michael, Guan, Shenheng, DeArmond, Stephen J, Renslo, Adam R, Prusiner, Stanley B
Published in The Journal of pharmacology and experimental therapeutics (01.10.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2015)
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Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells
Silber, B. Michael, Gever, Joel R., Rao, Satish, Li, Zhe, Renslo, Adam R., Widjaja, Kartika, Wong, Casper, Giles, Kurt, Freyman, Yevgeniy, Elepano, Manuel, Irwin, John J., Jacobson, Matthew P., Prusiner, Stanley B.
Published in Bioorganic & medicinal chemistry (15.03.2014)
Published in Bioorganic & medicinal chemistry (15.03.2014)
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Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity
Thompson, Mark J., Louth, Jennifer C., Ferrara, Steven, Jackson, Matthew P., Sorrell, Fiona J., Cochrane, Edward J., Gever, Joel, Baxendale, Sarah, Silber, B. Michael, Roehl, Henry H., Chen, Beining
Published in European journal of medicinal chemistry (01.09.2011)
Published in European journal of medicinal chemistry (01.09.2011)
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Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice
Giles, Kurt, Berry, David B, Condello, Carlo, Dugger, Brittany N, Li, Zhe, Oehler, Abby, Bhardwaj, Sumita, Elepano, Manuel, Guan, Shenheng, Silber, B Michael, Olson, Steven H, Prusiner, Stanley B
Published in The Journal of pharmacology and experimental therapeutics (01.09.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2016)
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Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice
Lu, Duo, Giles, Kurt, Li, Zhe, Rao, Satish, Dolghih, Elena, Gever, Joel R, Geva, Michal, Elepano, Manuel L, Oehler, Abby, Bryant, Clifford, Renslo, Adam R, Jacobson, Matthew P, Dearmond, Stephen J, Silber, B Michael, Prusiner, Stanley B
Published in The Journal of pharmacology and experimental therapeutics (01.11.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2013)
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Pharmacokinetics and Metabolism of 2-Aminothiazoles with Antiprion Activity in Mice
Silber, B. Michael, Rao, Satish, Fife, Kimberly L., Gallardo-Godoy, Alejandra, Renslo, Adam R., Dalvie, Deepak K., Giles, Kurt, Freyman, Yevgeniy, Elepano, Manuel, Gever, Joel R., Li, Zhe, Jacobson, Matthew P., Huang, Yong, Benet, Leslie Z., Prusiner, Stanley B.
Published in Pharmaceutical research (01.04.2013)
Published in Pharmaceutical research (01.04.2013)
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Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells
Silber, B Michael, Gever, Joel R, Li, Zhe, Gallardo-Godoy, Alejandra, Renslo, Adam R, Widjaja, Kartika, Irwin, John J, Rao, Satish, Jacobson, Matthew P, Ghaemmaghami, Sina, Prusiner, Stanley B
Published in Bioorganic & medicinal chemistry (15.12.2013)
Published in Bioorganic & medicinal chemistry (15.12.2013)
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The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
Obach, R S, Baxter, J G, Liston, T E, Silber, B M, Jones, B C, MacIntyre, F, Rance, D J, Wastall, P
Published in The Journal of pharmacology and experimental therapeutics (01.10.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.10.1997)
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2-Aminothiazoles with Improved Pharmacotherapeutic Properties for Treatment of Prion Disease
Li, Zhe, Silber, B. Michael, Rao, Satish, Gever, Joel R., Bryant, Clifford, Gallardo-Godoy, Alejandra, Dolghih, Elena, Widjaja, Kartika, Elepano, Manuel, Jacobson, Matthew P., Prusiner, Stanley B., Renslo, Adam R.
Published in ChemMedChem (01.05.2013)
Published in ChemMedChem (01.05.2013)
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CYP2D6 genotyping as an alternative to phenotyping for determination of metabolic status in a clinical trial setting
McElroy, S, Sachse, C, Brockmoller, J, Richmond, J, Lira, M, Friedman, D, Roots, I, Silber, B M, Milos, P M
Published in AAPS PharmSci (01.01.2000)
Published in AAPS PharmSci (01.01.2000)
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Antiprion compounds that reduce PrPSc levels in dividing and stationary-phase cells
Silber, B. Michael, Gever, Joel R., Li, Zhe, Gallardo-Godoy, Alejandra, Renslo, Adam R., Widjaja, Kartika, Irwin, John J., Rao, Satish, Jacobson, Matthew P., Ghaemmaghami, Sina, Prusiner, Stanley B.
Published in Bioorganic & medicinal chemistry (15.12.2013)
Published in Bioorganic & medicinal chemistry (15.12.2013)
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Discovery and Preliminary Structure–Activity Relationship of Arylpiperazines as Novel, Brain-Penetrant Antiprion Compounds
Li, Zhe, Gever, Joel R, Rao, Satish, Widjaja, Kartika, Prusiner, Stanley B, Silber, B. Michael
Published in ACS medicinal chemistry letters (11.04.2013)
Published in ACS medicinal chemistry letters (11.04.2013)
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Toward a 21st-century health care system: recommendations for health care reform
Arrow, Kenneth, Auerbach, Alan, Bertko, John, Brownlee, Shannon, Casalino, Lawrence P, Cooper, Jim, Crosson, Francis J, Enthoven, Alain, Falcone, Elizabeth, Feldman, Robert C, Fuchs, Victor R, Garber, Alan M, Gold, Marthe R, Goldman, Dana, Hadfield, Gillian K, Hall, Mark A, Horwitz, Ralph I, Hooven, Michael, Jacobson, Peter D, Jost, Timothy Stoltzfus, Kotlikoff, Lawrence J, Levin, Jonathan, Levine, Sharon, Levy, Richard, Linscott, Karen, Luft, Harold S, Mashal, Robert, McFadden, Daniel, Mechanic, David, Meltzer, David, Newhouse, Joseph P, Noll, Roger G, Pietzsch, Jan B, Pizzo, Philip, Reischauer, Robert D, Rosenbaum, Sara, Sage, William, Schaeffer, Leonard D, Sheen, Edward, Silber, B Michael, Skinner, Jonathan, Shortell, Stephen M, Thier, Samuel O, Tunis, Sean, Wulsin, Jr, Lucien, Yock, Paul, Nun, Gabi Bin, Bryan, Stirling, Luxenburg, Osnat, van de Ven, Wynand P M M
Published in Annals of internal medicine (07.04.2009)
Published in Annals of internal medicine (07.04.2009)
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Optimization of Arylamides as Novel, Potent and Brain-penetrant Antiprion Lead Compounds
Li, Zhe, Rao, Satish, Gever, Joel R, Widjaja, Kartika, Prusiner, Stanley B, Silber, B Michael
Published in ACS medicinal chemistry letters (11.07.2013)
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Published in ACS medicinal chemistry letters (11.07.2013)
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Pharmacokinetic profile of cefixime in man
Faulkner, R D, Yacobi, A, Barone, J S, Kaplan, S A, Silber, B M
Published in The Pediatric infectious disease journal (01.10.1987)
Published in The Pediatric infectious disease journal (01.10.1987)
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