GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER plus Breast Cancer
Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O'Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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Journal Article
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer
Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O’Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation
Hanan, Emily J, Eigenbrot, Charles, Bryan, Marian C, Burdick, Daniel J, Chan, Bryan K, Chen, Yuan, Dotson, Jennafer, Heald, Robert A, Jackson, Philip S, La, Hank, Lainchbury, Michael D, Malek, Shiva, Purkey, Hans E, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M, Sideris, Steve, Tam, Christine, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yin, Jianping, Yu, Christine, Zilberleyb, Inna, Heffron, Timothy P
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927
Labadie, Sharada S., Li, Jun, Blake, Robert A., Chang, Jae H., Goodacre, Simon, Hartman, Steven J., Liang, Weiling, Kiefer, James R., Kleinheinz, Tracy, Lai, Tommy, Liao, Jiangpeng, Ortwine, Daniel F., Mody, Vidhi, Ray, Nicholas C., Roussel, Fabien, Vinogradova, Maia, Yeap, Siew Kuen, Zhang, Birong, Zheng, Xiaoping, Zbieg, Jason R., Liang, Jun, Wang, Xiaojing
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Journal Article
Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor
Chan, Bryan K, Hanan, Emily J, Bowman, Krista K, Bryan, Marian C, Burdick, Daniel, Chan, Emily, Chen, Yuan, Clausen, Saundra, Dela Vega, Trisha, Dotson, Jennafer, Eigenbrot, Charles, Elliott, Richard L, Heald, Robert A, Jackson, Philip S, Knight, Jamie D, La, Hank, Lainchbury, Michael D, Malek, Shiva, Purkey, Hans E, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M, Sideris, Steve, Shao, Lily, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yu, Christine, Heffron, Timothy P
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
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THERAPEUTIC COMPOUNDS
LUCAS, CATHY LOUISE, NOWAK, THORSTEN, HYND, GEORGE, YEAP, SIEW KUEN, RUSSELL, MICHAEL GEOFFREY NEIL, ROUSSEL, FABIEN JEAN GHISLAIN, MARTIN, BARRIE PHILLIP, CRUMPLER, SIMON ROSS, EVANS, DAVID GARETH, LE BOZEC, LUCILLE, CRICK, DUNCAN JAMES, SEWARD, EILEEN MARY, RAY, NICK CHARLES, BLANEY, EMMA LOUISE, SEHMI, SANJEET SINGH
Year of Publication 04.03.2024
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Year of Publication 04.03.2024
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THERAPEUTIC COMPOUNDS
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Year of Publication 29.02.2024
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Year of Publication 29.02.2024
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THERAPEUTIC COMPOUNDS
RAY, Nick Charles, RUSSELL, Michael Geoffrey Neil, ROUSSEL, Fabien Jean Ghislain, LUCAS, Cathy Louise, CRUMPLER, Simon Ross, YEAP, Siew Kuen, EVANS, David Gareth, MARTIN, Barrie Phillip, NOWAK, Thorsten, LE BOZEC, Lucille, SEHMI, Sanjeet Singh, CRICK, Duncan James, HYND, George, BLANEY, Emma Louise, SEWARD, Eileen Mary
Year of Publication 28.02.2024
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Year of Publication 28.02.2024
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THERAPEUTIC COMPOUNDS
Seward, Eileen Mary, Lucas, Cathy Louise, Yeap, Siew Kuen, Le Bozec, Lucille, Russell, Michael Geoffrey Neil, Sehmi, Sanjeet Singh, Hynd, George, Nowak, Thorsten, Evans, David Gareth, Martin, Barrie Phillip, Crumpler, Simon Ross, Ray, Nick Charles, Roussel, Fabien Jean Ghislain, Crick, Duncan James, Blaney, Emma Louise
Year of Publication 02.02.2024
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Year of Publication 02.02.2024
Patent
THERAPEUTIC COMPOUNDS
LUCAS, CATHY LOUISE, NOWAK, THORSTEN, HYND, GEORGE, YEAP, SIEW KUEN, RUSSELL, MICHAEL GEOFFREY NEIL, ROUSSEL, FABIEN JEAN GHISLAIN, MARTIN, BARRIE PHILLIP, CRUMPLER, SIMON ROSS, EVANS, DAVID GARETH, LE BOZEC, LUCILLE, CRICK, DUNCAN JAMES, SEWARD, EILEEN MARY, RAY, NICK CHARLES, BLANEY, EMMA LOUISE, SEHMI, SANJEET SINGH
Year of Publication 29.12.2023
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Year of Publication 29.12.2023
Patent
THERAPEUTIC COMPOUNDS
RAY, Nick Charles, RUSSELL, Michael Geoffrey Neil, ROUSSEL, Fabien Jean Ghislain, LUCAS, Cathy Louise, CRUMPLER, Simon Ross, YEAP, Siew Kuen, EVANS, David Gareth, MARTIN, Barrie Phillip, NOWAK, Thorsten, LE BOZEC, Lucille, SEHMI, Sanjeet Singh, CRICK, Duncan James, HYND, George, BLANEY, Emma Louise, SEWARD, Eileen Mary
Year of Publication 11.12.2023
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Year of Publication 11.12.2023
Patent
TERAPEUTISKE FORBINDELSER
RAY, Nick Charles, RUSSELL, Michael Geoffrey Neil, ROUSSEL, Fabien Jean Ghislain, LUCAS, Cathy Louise, CRUMPLER, Simon Ross, YEAP, Siew Kuen, EVANS, David Gareth, MARTIN, Barrie Phillip, NOWAK, Thorsten, LE BOZEC, Lucille, SEHMI, Sanjeet Singh, CRICK, Duncan James, HYND, George, BLANEY, Emma Louise, SEWARD, Eileen Mary
Year of Publication 13.11.2023
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Year of Publication 13.11.2023
Patent
THERAPEUTIC COMPOUNDS
RAY, Nick Charles, RUSSELL, Michael Geoffrey Neil, ROUSSEL, Fabien Jean Ghislain, LUCAS, Cathy Louise, CRUMPLER, Simon Ross, YEAP, Siew Kuen, EVANS, David Gareth, MARTIN, Barrie Phillip, NOWAK, Thorsten, LE BOZEC, Lucille, SEHMI, Sanjeet Singh, CRICK, Duncan James, HYND, George, BLANEY, Emma Louise, SEWARD, Eileen Mary
Year of Publication 08.11.2023
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Year of Publication 08.11.2023
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THERAPEUTIC COMPOUNDS
RAY, Nick Charles, RUSSELL, Michael Geoffrey Neil, ROUSSEL, Fabien Jean Ghislain, LUCAS, Cathy Louise, CRUMPLER, Simon Ross, YEAP, Siew Kuen, EVANS, David Gareth, MARTIN, Barrie Phillip, NOWAK, Thorsten, LE BOZEC, Lucille, SEHMI, Sanjeet Singh, CRICK, Duncan James, HYND, George, BLANEY, Emma Louise, SEWARD, Eileen Mary
Year of Publication 03.11.2023
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Year of Publication 03.11.2023
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THERAPEUTIC COMPOUNDS
RAY, Nick Charles, RUSSELL, Michael Geoffrey Neil, ROUSSEL, Fabien Jean Ghislain, LUCAS, Cathy Louise, CRUMPLER, Simon Ross, YEAP, Siew Kuen, EVANS, David Gareth, MARTIN, Barrie Phillip, NOWAK, Thorsten, LE BOZEC, Lucille, SEHMI, Sanjeet Singh, CRICK, Duncan James, HYND, George, BLANEY, Emma Louise, SEWARD, Eileen Mary
Year of Publication 04.10.2023
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Year of Publication 04.10.2023
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THERAPEUTIC COMPOUNDS
RAY, Nick Charles, RUSSELL, Michael Geoffrey Neil, ROUSSEL, Fabien Jean Ghislain, LUCAS, Cathy Louise, CRUMPLER, Simon Ross, YEAP, Siew Kuen, EVANS, David Gareth, MARTIN, Barrie Phillip, NOWAK, Thorsten, LE BOZEC, Lucille, SEHMI, Sanjeet Singh, CRICK, Duncan James, HYND, George, BLANEY, Emma Louise, SEWARD, Eileen Mary
Year of Publication 16.08.2023
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Year of Publication 16.08.2023
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Therapeutic compounds
RAY, Nick Charles, RUSSELL, Michael Geoffrey Neil, ROUSSEL, Fabien Jean Ghislain, LUCAS, Cathy Louise, CRUMPLER, Simon Ross, YEAP, Siew Kuen, EVANS, David Gareth, MARTIN, Barrie Phillip, NOWAK, Thorsten, LE BOZEC, Lucille, SEHMI, Sanjeet Singh, CRICK, Duncan James, HYND, George, BLANEY, Emma Louise, SEWARD, Eileen Mary
Year of Publication 20.07.2023
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Year of Publication 20.07.2023
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THERAPEUTIC COMPOUNDS
RAY, Nick Charles, RUSSELL, Michael Geoffrey Neil, ROUSSEL, Fabien Jean Ghislain, LUCAS, Cathy Louise, CRUMPLER, Simon Ross, YEAP, Siew Kuen, EVANS, David Gareth, MARTIN, Barrie Phillip, NOWAK, Thorsten, LE BOZEC, Lucille, SEHMI, Sanjeet Singh, CRICK, Duncan James, HYND, George, BLANEY, Emma Louise, SEWARD, Eileen Mary
Year of Publication 06.12.2021
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Year of Publication 06.12.2021
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Tricyclic PI3K inhibitor compounds and methods of use
Heald, Robert Andrew, Hanan, Emily, Lu, Aijun, Yeap, Siew Kuen, Wu, Guosheng, Macleod, Calum, Braun, Marie-Gabrielle, Staben, Steven T, Garland, Keira, Purkey, Hans, Knight, Jamie
Year of Publication 08.10.2019
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Year of Publication 08.10.2019
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