Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor
Fu, Qingshan, Fu, Tian-Min, Cruz, Anthony C., Sengupta, Prabuddha, Thomas, Stacy K., Wang, Shuqing, Siegel, Richard M., Wu, Hao, Chou, James J.
Published in Molecular cell (18.02.2016)
Published in Molecular cell (18.02.2016)
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Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex
Fu, Tian-Min, Li, Yang, Lu, Alvin, Li, Zongli, Vajjhala, Parimala R., Cruz, Anthony C., Srivastava, Devendra B., DiMaio, Frank, Penczek, Pawel A., Siegel, Richard M., Stacey, Katryn J., Egelman, Edward H., Wu, Hao
Published in Molecular cell (20.10.2016)
Published in Molecular cell (20.10.2016)
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Journal Article
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
Bulua, Ariel C, Simon, Anna, Maddipati, Ravikanth, Pelletier, Martin, Park, Heiyoung, Kim, Kye-Young, Sack, Michael N, Kastner, Daniel L, Siegel, Richard M
Published in The Journal of experimental medicine (14.03.2011)
Published in The Journal of experimental medicine (14.03.2011)
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Journal Article
Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection
Wilhelm, Christoph, Harrison, Oliver J, Schmitt, Vanessa, Pelletier, Martin, Spencer, Sean P, Urban, Jr, Joseph F, Ploch, Michelle, Ramalingam, Thirumalai R, Siegel, Richard M, Belkaid, Yasmine
Published in The Journal of experimental medicine (25.07.2016)
Published in The Journal of experimental medicine (25.07.2016)
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Journal Article
Lighting the fires within: the cell biology of autoinflammatory diseases
Park, Heiyoung, Bourla, Ariel Bulua, Kastner, Daniel L, Colbert, Robert A, Siegel, Richard M
Published in Nature reviews. Immunology (01.08.2012)
Published in Nature reviews. Immunology (01.08.2012)
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TNF superfamily cytokines in the promotion of Th9 differentiation and immunopathology
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Book Review
Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects
Traba, Javier, Kwarteng-Siaw, Miriam, Okoli, Tracy C, Li, Jessica, Huffstutler, Rebecca D, Bray, Amanda, Waclawiw, Myron A, Han, Kim, Pelletier, Martin, Sauve, Anthony A, Siegel, Richard M, Sack, Michael N
Published in The Journal of clinical investigation (01.12.2015)
Published in The Journal of clinical investigation (01.12.2015)
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Journal Article
TNF receptor 1 genetic risk mirrors outcome of anti―TNF therapy in multiple sclerosis
GREGORY, Adam P, DENDROU, Calliope A, PRÖMEL, Simone, PUNWANI, Divya, FELCE, James H, DAVIS, Simon J, GOLD, Ralf, NIELSEN, Finn C, SIEGEL, Richard M, MANN, Matthias, BELL, John I, MCVEAN, Gil, ATTFIELD, Kathrine E, FUGGER, Lars, HAGHIKIA, Aiden, XIFARA, Dionysia K, BUTTER, Falk, POSCHMANN, Gereon, KAUR, Gurman, LAMBERT, Lydia, LEACH, Oliver A
Published in Nature (London) (23.08.2012)
Published in Nature (London) (23.08.2012)
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Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop
Oliveira, Joao B., Bleesing, Jack J., Dianzani, Umberto, Fleisher, Thomas A., Jaffe, Elaine S., Lenardo, Michael J., Rieux-Laucat, Frederic, Siegel, Richard M., Su, Helen C., Teachey, David T., Rao, V. Koneti
Published in Blood (07.10.2010)
Published in Blood (07.10.2010)
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Journal Article
Conference Proceeding
Distinct Functions of Autoantibodies Against Interferon in Systemic Lupus Erythematosus: A Comprehensive Analysis of Anticytokine Autoantibodies in Common Rheumatic Diseases
Gupta, Sarthak, Tatouli, Ioanna P., Rosen, Lindsey B., Hasni, Sarfaraz, Alevizos, Ilias, Manna, Zerai G., Rivera, Juan, Jiang, Chao, Siegel, Richard M., Holland, Steven M., Moutsopoulos, Haralampos M., Browne, Sarah K.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.07.2016)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.07.2016)
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Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
Gomez-Rodriguez, Julio, Meylan, Françoise, Handon, Robin, Hayes, Erika T, Anderson, Stacie M, Kirby, Martha R, Siegel, Richard M, Schwartzberg, Pamela L
Published in Nature communications (03.03.2016)
Published in Nature communications (03.03.2016)
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Somatic activating mutations in MAP2K1 cause melorheostosis
Kang, Heeseog, Jha, Smita, Deng, Zuoming, Fratzl-Zelman, Nadja, Cabral, Wayne A, Ivovic, Aleksandra, Meylan, Françoise, Hanson, Eric P, Lange, Eileen, Katz, James, Roschger, Paul, Klaushofer, Klaus, Cowen, Edward W, Siegel, Richard M, Marini, Joan C, Bhattacharyya, Timothy
Published in Nature communications (11.04.2018)
Published in Nature communications (11.04.2018)
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Journal Article
Progranulin Resolves Inflammation
Wu, Hao, Siegel, Richard M.
Published in Science (American Association for the Advancement of Science) (22.04.2011)
Published in Science (American Association for the Advancement of Science) (22.04.2011)
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Journal Article
Safety and Tolerability of Omalizumab: A Randomized Clinical Trial of Humanized Anti‐IgE Monoclonal Antibody in Systemic Lupus Erythematosus
Hasni, Sarfaraz, Gupta, Sarthak, Davis, Michael, Poncio, Elaine, Temesgen‐Oyelakin, Yenealem, Joyal, Elizabeth, Fike, Alice, Manna, Zerai, Auh, Sungyoung, Shi, Yinghui, Chan, Diana, Carlucci, Philip, Biehl, Ann, Dema, Barbara, Charles, Nicolas, Balow, James E., Waldman, Meryl, Siegel, Richard M., Kaplan, Mariana J., Rivera, Juan
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.07.2019)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.07.2019)
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Journal Article
Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling
Geiger, Sarah S, Traba, Javier, Richoz, Nathan, Farley, Taylor K, Brooks, Stephen R, Petermann, Franziska, Wang, Lingdi, Gonzalez, Frank J, Sack, Michael N, Siegel, Richard M
Published in Nature communications (12.05.2021)
Published in Nature communications (12.05.2021)
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Journal Article
Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils
Zhou, Yebin, Chen, Bo, Mittereder, Nanette, Chaerkady, Raghothama, Strain, Martin, An, Ling-Ling, Rahman, Saifur, Ma, Wenting, Low, Choon Pei, Chan, Denice, Neal, Frances, Bingham, 3rd, Clifton O, Sampson, Kevon, Darrah, Erika, Siegel, Richard M, Hasni, Sarfaraz, Andrade, Felipe, Vousden, Katherine A, Mustelin, Tomas, Sims, Gary P
Published in Frontiers in immunology (25.09.2017)
Published in Frontiers in immunology (25.09.2017)
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Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease
Zilberman-Rudenko, Jevgenia, Shawver, Linda Monaco, Wessel, Alex W., Luo, Yongquan, Pelletier, Martin, Tsai, Wanxia Li, Lee, Younglang, Vonortas, Spiridon, Cheng, Laurence, Ashwell, Jonathan D., Orange, Jordan S., Siegel, Richard M., Hanson, Eric P.
Published in Proceedings of the National Academy of Sciences - PNAS (09.02.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (09.02.2016)
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