Exploring the specificity of the PI3K family inhibitor LY294002
Gharbi, Severine I, Zvelebil, Marketa J, Shuttleworth, Stephen J, Hancox, Tim, Saghir, Nahid, Timms, John F, Waterfield, Michael D
Published in Biochemical journal (15.05.2007)
Published in Biochemical journal (15.05.2007)
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Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy
Gyori, David, Lim, Ee Lyn, Grant, Francis M, Spensberger, Dominik, Roychoudhuri, Rahul, Shuttleworth, Stephen J, Okkenhaug, Klaus, Stephens, Len R, Hawkins, Phillip T
Published in JCI insight (07.06.2018)
Published in JCI insight (07.06.2018)
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The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer
Folkes, Adrian J, Ahmadi, Khatereh, Alderton, Wendy K, Alix, Sonia, Baker, Stewart J, Box, Gary, Chuckowree, Irina S, Clarke, Paul A, Depledge, Paul, Eccles, Suzanne A, Friedman, Lori S, Hayes, Angela, Hancox, Timothy C, Kugendradas, Arumugam, Lensun, Letitia, Moore, Pauline, Olivero, Alan G, Pang, Jodie, Patel, Sonal, Pergl-Wilson, Giles H, Raynaud, Florence I, Robson, Anthony, Saghir, Nahid, Salphati, Laurent, Sohal, Sukhjit, Ultsch, Mark H, Valenti, Melanie, Wallweber, Heidi J.A, Wan, Nan Chi, Wiesmann, Christian, Workman, Paul, Zhyvoloup, Alexander, Zvelebil, Marketa J, Shuttleworth, Stephen J
Published in Journal of medicinal chemistry (25.09.2008)
Published in Journal of medicinal chemistry (25.09.2008)
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Inhibition of Histone Deacetylase 6 Reveals a Potent Immunosuppressant Effect in Models of Transplantation
Ellis, Jonathan D, Neil, Desley A H, Inston, Nick G, Jenkinson, Eric, Drayson, Mark T, Hampson, Peter, Shuttleworth, Stephen J, Ready, Andrew R, Cobbold, Mark
Published in Transplantation (01.08.2016)
Published in Transplantation (01.08.2016)
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Journal Article
Functional characterization of a novel somatic oncogenic mutation of PIK3CB
Whale, Andrew D, Colman, Lucy, Lensun, Letitia, Rogers, Helen L, Shuttleworth, Stephen J
Published in Signal transduction and targeted therapy (01.01.2017)
Published in Signal transduction and targeted therapy (01.01.2017)
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Journal Article
Structural analysis of PI3-kinase isoforms: Identification of residues enabling selective inhibition by small molecule ATP-competitive inhibitors
Zvelebil, Marketa J., Waterfield, Michael D., Shuttleworth, Stephen J.
Published in Archives of biochemistry and biophysics (15.09.2008)
Published in Archives of biochemistry and biophysics (15.09.2008)
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Discovery and optimization of a novel Neuromedin B receptor antagonist
Fu, Jiasheng, Shuttleworth, Stephen J., Connors, Richard V., Chai, Anne, Coward, Peter
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements
Large, Jonathan M., Torr, Jane E., Raynaud, Florence I., Clarke, Paul A., Hayes, Angela, Stefano, Francesca di, Urban, Frederique, Shuttleworth, Stephen J., Saghir, Nahid, Sheldrake, Peter, Workman, Paul, McDonald, Edward
Published in Bioorganic & medicinal chemistry (15.01.2011)
Published in Bioorganic & medicinal chemistry (15.01.2011)
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Journal Article
Parallel synthesis of isatin-based serine protease inhibitors
Shuttleworth, Stephen J., Nasturica, Daniel, Gervais, Christian, Siddiqui, M.Arshad, Rando, Robert F., Lee, Nola
Published in Bioorganic & medicinal chemistry letters (20.11.2000)
Published in Bioorganic & medicinal chemistry letters (20.11.2000)
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Journal Article
PHARMACEUTICAL COMPOUNDS
LATIF MOHAMMED A, CHUCKOWREE IRINA S, HANCOX TIMOTHY C, SOHAL SUKHJIT, BAKER STEWART J, FOLKES ADRIAN J, WAN NAN CHI, SHUTTLEWORTH STEPHEN J
Year of Publication 19.06.2013
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Year of Publication 19.06.2013
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