Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
Garcia Fortanet, Jorge, Chen, Christine Hiu-Tung, Chen, Ying-Nan P, Chen, Zhouliang, Deng, Zhan, Firestone, Brant, Fekkes, Peter, Fodor, Michelle, Fortin, Pascal D, Fridrich, Cary, Grunenfelder, Denise, Ho, Samuel, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Keen, Nick, LaBonte, Laura R, Larrow, Jay, Lenoir, Francois, Liu, Gang, Liu, Shumei, Lombardo, Franco, Majumdar, Dyuti, Meyer, Matthew J, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Sellers, William R, Shultz, Michael D, Stams, Travis, Towler, Christopher, Wang, Ping, Williams, Sarah L, Zhang, Ji-Hu, LaMarche, Matthew J
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
Chen, Ying-Nan P, LaMarche, Matthew J, Chan, Ho Man, Fekkes, Peter, Garcia-Fortanet, Jorge, Acker, Michael G, Antonakos, Brandon, Chen, Christine Hiu-Tung, Chen, Zhouliang, Cooke, Vesselina G, Dobson, Jason R, Deng, Zhan, Fei, Feng, Firestone, Brant, Fodor, Michelle, Fridrich, Cary, Gao, Hui, Grunenfelder, Denise, Hao, Huai-Xiang, Jacob, Jaison, Ho, Samuel, Hsiao, Kathy, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Larrow, Jay, La Bonte, Laura R, Lenoir, Francois, Liu, Gang, Liu, Shumei, Majumdar, Dyuti, Meyer, Matthew J, Palermo, Mark, Perez, Lawrence, Pu, Minying, Price, Edmund, Quinn, Christopher, Shakya, Subarna, Shultz, Michael D, Slisz, Joanna, Venkatesan, Kavitha, Wang, Ping, Warmuth, Markus, Williams, Sarah, Yang, Guizhi, Yuan, Jing, Zhang, Ji-Hu, Zhu, Ping, Ramsey, Timothy, Keen, Nicholas J, Sellers, William R, Stams, Travis, Fortin, Pascal D
Published in Nature (London) (07.07.2016)
Published in Nature (London) (07.07.2016)
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Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer
LaMarche, Matthew J, Acker, Michael, Argintaru, Andreea, Bauer, Daniel, Boisclair, Julie, Chan, Homan, Chen, Christine Hiu-Tung, Chen, Ying-Nan, Chen, Zhouliang, Deng, Zhan, Dore, Michael, Dunstan, David, Fan, Jianmei, Fekkes, Peter, Firestone, Brant, Fodor, Michelle, Garcia-Fortanet, Jorge, Fortin, Pascal D, Fridrich, Cary, Giraldes, John, Glick, Meir, Grunenfelder, Denise, Hao, Huia-Xiang, Hentemann, Martin, Ho, Samuel, Jouk, Andriana, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Keen, Nick, Koenig, Robert, LaBonte, Laura R, Larrow, Jay, Liu, Gang, Liu, Shumei, Majumdar, Dyuti, Mathieu, Simon, Meyer, Matthew J, Mohseni, Morvarid, Ntaganda, Rukundo, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Reilly, John, Sarver, Patrick, Sellers, William R, Sendzik, Martin, Shultz, Michael D, Slisz, Joanna, Slocum, Kelly, Smith, Troy, Spence, Stanley, Stams, Travis, Straub, Christopher, Tamez, Victoriano, Toure, Bakary-Barry, Towler, Christopher, Wang, Ping, Wang, Hongyun, Williams, Sarah L, Yang, Fan, Yu, Bing, Zhang, Ji-Hu, Zhu, Suzanne
Published in Journal of medicinal chemistry (25.11.2020)
Published in Journal of medicinal chemistry (25.11.2020)
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A Review of Recent Advances in Automated Guided Vehicle Technologies: Integration Challenges and Research Areas for 5G-Based Smart Manufacturing Applications
Oyekanlu, Emmanuel A., Smith, Alexander C., Thomas, Windsor P., Mulroy, Grethel, Hitesh, Dave, Ramsey, Matthew, Kuhn, David J., Mcghinnis, Jason D., Buonavita, Steven C., Looper, Nickolus A., Ng, Mason, Ng'oma, Anthony, Liu, Weimin, Mcbride, Patrick G., Shultz, Michael G., Cerasi, Craig, Sun, Dan
Published in IEEE access (2020)
Published in IEEE access (2020)
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Evolution of Novartis’ Small Molecule Screening Deck Design
Schuffenhauer, Ansgar, Schneider, Nadine, Hintermann, Samuel, Auld, Douglas, Blank, Jutta, Cotesta, Simona, Engeloch, Caroline, Fechner, Nikolas, Gaul, Christoph, Giovannoni, Jerome, Jansen, Johanna, Joslin, John, Krastel, Philipp, Lounkine, Eugen, Manchester, John, Monovich, Lauren G, Pelliccioli, Anna Paola, Schwarze, Manuel, Shultz, Michael D, Stiefl, Nikolaus, Baeschlin, Daniel K
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
Huang, Ying, Zhang, Jeff, Yu, Zhengtian, Zhang, Hailong, Wang, Youzhen, Lingel, Andreas, Qi, Wei, Gu, Justin, Zhao, Kehao, Shultz, Michael D, Wang, Long, Fu, Xingnian, Sun, Yongfeng, Zhang, Qiong, Jiang, Xiangqing, Zhang, Jiangwei, Zhang, Chunye, Li, Ling, Zeng, Jue, Feng, Lijian, Zhang, Chao, Liu, Yueqin, Zhang, Man, Zhang, Lijun, Zhao, Mengxi, Gao, Zhenting, Liu, Xianghui, Fang, Douglas, Guo, Haibing, Mi, Yuan, Gabriel, Tobias, Dillon, Michael P, Atadja, Peter, Oyang, Counde
Published in Journal of medicinal chemistry (23.03.2017)
Published in Journal of medicinal chemistry (23.03.2017)
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Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase
Lingel, Andreas, Sendzik, Martin, Huang, Ying, Shultz, Michael D, Cantwell, John, Dillon, Michael P, Fu, Xingnian, Fuller, John, Gabriel, Tobias, Gu, Justin, Jiang, Xiangqing, Li, Ling, Liang, Fang, McKenna, Maureen, Qi, Wei, Rao, Weijun, Sheng, Xijun, Shu, Wei, Sutton, James, Taft, Benjamin, Wang, Long, Zeng, Jue, Zhang, Hailong, Zhang, Maya, Zhao, Kehao, Lindvall, Mika, Bussiere, Dirksen E
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
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Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor
Shultz, Michael D, Cheung, Atwood K, Kirby, Christina A, Firestone, Brant, Fan, Jianmei, Chen, Christine Hiu-Tung, Chen, Zhouliang, Chin, Donovan N, DiPietro, Lucian, Fazal, Aleem, Feng, Yun, Fortin, Pascal D, Gould, Ty, Lagu, Bharat, Lei, Huangshu, Lenoir, Francois, Majumdar, Dyuti, Ochala, Etienne, Palermo, M. G, Pham, Ly, Pu, Minying, Smith, Troy, Stams, Travis, Tomlinson, Ronald C, Touré, B. Barry, Visser, Michael, Wang, Run Ming, Waters, Nigel J, Shao, Wenlin
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
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Food availability and population processes: severity of nutritional stress during reproduction predicts survival of long-lived seabirds
Kitaysky, Alexander S, Piatt, John F, Hatch, Scott A, Kitaiskaia, Evgenia V, Benowitz-Fredericks, Z. Morgan, Shultz, Michael T, Wingfield, John C
Published in Functional ecology (01.06.2010)
Published in Functional ecology (01.06.2010)
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Impact of ventricular ectopic burden in a premature ventricular contraction–induced cardiomyopathy animal model
Tan, Alex Y., MD, Hu, Yuhning L., MD, Potfay, Jonathan, MD, Kaszala, Karoly, MD, PhD, FHRS, Howren, Maureen, BS, Sima, Adam P., PhD, Shultz, Michael, PhD, Koneru, Jayanthi N., MD, Ellenbogen, Kenneth A., MD, FHRS, Huizar, Jose F., MD, FHRS
Published in Heart rhythm (01.03.2016)
Published in Heart rhythm (01.03.2016)
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Metallofullerene-based Nanoplatform for Brain Tumor Brachytherapy and Longitudinal Imaging in a Murine Orthotopic Xenograft \Model
SHULTZ, Michael D, WILSON, John D, FULLER, Christine E, JIANYUAN ZHANG, DORN, Harry C, FATOUROS, Panos P
Published in Radiology (01.10.2011)
Published in Radiology (01.10.2011)
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hnRNP U Enhances Caspase-9 Splicing and Is Modulated by AKT-dependent Phosphorylation of hnRNP L
Vu, Ngoc T., Park, Margaret A., Shultz, Jacqueline C., Goehe, Rachel W., Hoeferlin, L.Alexis, Shultz, Michael D., Smith, Sarah A., Lynch, Kristen W., Chalfant, Charles E.
Published in The Journal of biological chemistry (22.03.2013)
Published in The Journal of biological chemistry (22.03.2013)
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Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase[S]
Mietla, Jennifer A., Wijesinghe, Dayanjan S., Hoeferlin, L. Alexis, Shultz, Michael D., Natarajan, Ramesh, Fowler, Alpha A., Chalfant, Charles E.
Published in Journal of lipid research (01.07.2013)
Published in Journal of lipid research (01.07.2013)
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