Humanized Mouse Models of Clinical Disease
Walsh, Nicole C, Kenney, Laurie L, Jangalwe, Sonal, Aryee, Ken-Edwin, Greiner, Dale L, Brehm, Michael A, Shultz, Leonard D
Published in Annual review of pathology (24.01.2017)
Published in Annual review of pathology (24.01.2017)
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Journal Article
Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status
Li, Peishan, Lu, Ming, Shi, Jiayuan, Hua, Li, Gong, Zheng, Li, Qing, Shultz, Leonard D., Ren, Guangwen
Published in Nature communications (01.09.2020)
Published in Nature communications (01.09.2020)
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Journal Article
MEK Guards Proteome Stability and Inhibits Tumor-Suppressive Amyloidogenesis via HSF1
Tang, Zijian, Dai, Siyuan, He, Yishu, Doty, Rosalinda A., Shultz, Leonard D., Sampson, Stephen Byers, Dai, Chengkai
Published in Cell (12.02.2015)
Published in Cell (12.02.2015)
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Journal Article
Humanized mice in translational biomedical research
Shultz, Leonard D, Ishikawa, Fumihiko, Greiner, Dale L
Published in Nature Reviews: Immunology (01.02.2007)
Published in Nature Reviews: Immunology (01.02.2007)
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Journal Article
Humanized mice in studying efficacy and mechanisms of PD‐1‐targeted cancer immunotherapy
Wang, Minan, Yao, Li‐Chin, Cheng, Mingshan, Cai, Danying, Martinek, Jan, Pan, Chong‐Xian, Shi, Wei, Ma, Ai‐Hong, Vere White, Ralph W., Airhart, Susan, Liu, Edison T., Banchereau, Jacques, Brehm, Michael A., Greiner, Dale L., Shultz, Leonard D., Palucka, Karolina, Keck, James G.
Published in The FASEB journal (01.03.2018)
Published in The FASEB journal (01.03.2018)
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Journal Article
Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma
Crescenzo, Ramona, Abate, Francesco, Lasorsa, Elena, Tabbo’, Fabrizio, Gaudiano, Marcello, Chiesa, Nicoletta, Di Giacomo, Filomena, Spaccarotella, Elisa, Barbarossa, Luigi, Ercole, Elisabetta, Todaro, Maria, Boi, Michela, Acquaviva, Andrea, Ficarra, Elisa, Novero, Domenico, Rinaldi, Andrea, Tousseyn, Thomas, Rosenwald, Andreas, Kenner, Lukas, Cerroni, Lorenzo, Tzankov, Alexander, Ponzoni, Maurilio, Paulli, Marco, Weisenburger, Dennis, Chan, Wing C., Iqbal, Javeed, Piris, Miguel A., Zamo’, Alberto, Ciardullo, Carmela, Rossi, Davide, Gaidano, Gianluca, Pileri, Stefano, Tiacci, Enrico, Falini, Brunangelo, Shultz, Leonard D., Mevellec, Laurence, Vialard, Jorge E., Piva, Roberto, Bertoni, Francesco, Rabadan, Raul, Inghirami, Giorgio
Published in Cancer cell (13.04.2015)
Published in Cancer cell (13.04.2015)
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Journal Article
AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice
Youngblood, Bradford A., Brock, Emily C., Leung, John, Falahati, Rustom, Bryce, Paul J., Bright, Jessica, Williams, Jason, Shultz, Leonard D., Greiner, Dale L., Brehm, Michael A., Bebbington, Christopher, Tomasevic, Nenad
Published in International archives of allergy and immunology (01.09.2019)
Published in International archives of allergy and immunology (01.09.2019)
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Journal Article
Overcoming Current Limitations in Humanized Mouse Research
Brehm, Michael A., Shultz, Leonard D., Luban, Jeremy, Greiner, Dale L.
Published in The Journal of infectious diseases (15.11.2013)
Published in The Journal of infectious diseases (15.11.2013)
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Journal Article
Conference Proceeding
Generation of improved humanized mouse models for human infectious diseases
Brehm, Michael A., Wiles, Michael V., Greiner, Dale L., Shultz, Leonard D.
Published in Journal of immunological methods (01.08.2014)
Published in Journal of immunological methods (01.08.2014)
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Journal Article
Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML
Ishikawa, Fumihiko, Saito, Yoriko, Uchida, Naoyuki, Tanaka, Satoshi, Suzuki, Nahoko, Tomizawa-Murasawa, Mariko, Sone, Akiko, Najima, Yuho, Takagi, Shinsuke, Aoki, Yuki, Wake, Atsushi, Taniguchi, Shuichi, Shultz, Leonard D
Published in Nature biotechnology (01.03.2010)
Published in Nature biotechnology (01.03.2010)
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Journal Article
Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection
Sewald, Xaver, Ladinsky, Mark S., Uchil, Pradeep D., Beloor, Jagadish, Pi, Ruoxi, Herrmann, Christin, Motamedi, Nasim, Murrooka, Thomas T., Brehm, Michael A., Greiner, Dale L., Shultz, Leonard D., Mempel, Thorsten R., Bjorkman, Pamela J., Kumar, Priti, Mothes, Walther
Published in Science (American Association for the Advancement of Science) (30.10.2015)
Published in Science (American Association for the Advancement of Science) (30.10.2015)
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Journal Article
α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes
Brissova, Marcela, Haliyur, Rachana, Saunders, Diane, Shrestha, Shristi, Dai, Chunhua, Blodgett, David M., Bottino, Rita, Campbell-Thompson, Martha, Aramandla, Radhika, Poffenberger, Gregory, Lindner, Jill, Pan, Fong Cheng, von Herrath, Matthias G., Greiner, Dale L., Shultz, Leonard D., Sanyoura, May, Philipson, Louis H., Atkinson, Mark, Harlan, David M., Levy, Shawn E., Prasad, Nripesh, Stein, Roland, Powers, Alvin C.
Published in Cell reports (Cambridge) (06.03.2018)
Published in Cell reports (Cambridge) (06.03.2018)
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Journal Article
Humanized mouse model of mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis
Bryce, Paul J., PhD, Falahati, Rustom, PhD, Kenney, Laurie L., PhD, Leung, John, BS, Bebbington, Christopher, PhD, Tomasevic, Nenad, PhD, Krier, Rebecca A., MS, Hsu, Chia-Lin, PhD, Shultz, Leonard D., PhD, Greiner, Dale L., PhD, Brehm, Michael A., PhD
Published in Journal of allergy and clinical immunology (01.09.2016)
Published in Journal of allergy and clinical immunology (01.09.2016)
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Journal Article
Human cancer growth and therapy in immunodeficient mouse models
Shultz, Leonard D, Goodwin, Neal, Ishikawa, Fumihiko, Hosur, Vishnu, Lyons, Bonnie L, Greiner, Dale L
Published in Cold Spring Harbor protocols (01.07.2014)
Published in Cold Spring Harbor protocols (01.07.2014)
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Journal Article
Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells
Saito, Yoriko, Kitamura, Hiroshi, Hijikata, Atsushi, Tomizawa-Murasawa, Mariko, Tanaka, Satoshi, Takagi, Shinsuke, Uchida, Naoyuki, Suzuki, Nahoko, Sone, Akiko, Najima, Yuho, Ozawa, Hidetoshi, Wake, Atsushi, Taniguchi, Shuichi, Shultz, Leonard D, Ohara, Osamu, Ishikawa, Fumihiko
Published in Science translational medicine (03.02.2010)
Published in Science translational medicine (03.02.2010)
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Journal Article
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
Saito, Yoriko, Shultz, Leonard D, Saito, Noriyuki, Miyamoto, Toshihiro, Yoshida, Shuro, Hijikata, Atsushi, Nakamura, Ryu, Ohara, Osamu, Lyons, Bonnie, Ishikawa, Fumihiko, Taniguchi, Shuichi, Kitamura, Hiroshi, Fukata, Mitsuhiro, Uchida, Naoyuki, Tomiyama, Hiroko, Tanaka, Toru, Akashi, Koichi, Tanaka, Satoshi, Harada, Mine, Ohshima, Koichi
Published in Nature biotechnology (01.11.2007)
Published in Nature biotechnology (01.11.2007)
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Journal Article
Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation
Hosur, Vishnu, Low, Benjamin E, Li, Daniel, Stafford, Grace A, Kohar, Vivek, Shultz, Leonard D, Wiles, Michael V
Published in Genome Biology (09.07.2020)
Published in Genome Biology (09.07.2020)
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Journal Article
Stress-impaired transcription factor expression and insulin secretion in transplanted human islets
Dai, Chunhua, Kayton, Nora S, Shostak, Alena, Poffenberger, Greg, Cyphert, Holly A, Aramandla, Radhika, Thompson, Courtney, Papagiannis, Ioannis G, Emfinger, Christopher, Shiota, Masakazu, Stafford, John M, Greiner, Dale L, Herrera, Pedro L, Shultz, Leonard D, Stein, Roland, Powers, Alvin C
Published in The Journal of clinical investigation (01.05.2016)
Published in The Journal of clinical investigation (01.05.2016)
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Journal Article
A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
Mercado-Lubo, Regino, Zhang, Yuanwei, Zhao, Liang, Rossi, Kyle, Wu, Xiang, Zou, Yekui, Castillo, Antonio, Leonard, Jack, Bortell, Rita, Greiner, Dale L., Shultz, Leonard D., Han, Gang, McCormick, Beth A.
Published in Nature communications (25.07.2016)
Published in Nature communications (25.07.2016)
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