The arrhythmogenic consequences of increasing late INa in the cardiomyocyte
Shryock, John C, Song, Yejia, Rajamani, Sridharan, Antzelevitch, Charles, Belardinelli, Luiz
Published in Cardiovascular research (01.09.2013)
Published in Cardiovascular research (01.09.2013)
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Journal Article
Cardiac late Na+ current: Proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress
Belardinelli, Luiz, Giles, Wayne R., PhD, Rajamani, Sridharan, PhD, Karagueuzian, Hrayr S., PhD, FHRS, Shryock, John C., PhD
Published in Heart rhythm (01.02.2015)
Published in Heart rhythm (01.02.2015)
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Journal Article
Pathophysiology and pharmacology of the cardiac "late sodium current."
Zaza, Antonio, Belardinelli, Luiz, Shryock, John C
Published in Pharmacology & therapeutics (Oxford) (01.09.2008)
Published in Pharmacology & therapeutics (Oxford) (01.09.2008)
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Journal Article
A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias
Belardinelli, Luiz, Liu, Gongxin, Smith-Maxwell, Cathy, Wang, Wei-Qun, El-Bizri, Nesrine, Hirakawa, Ryoko, Karpinski, Serge, Li, Cindy Hong, Hu, Lufei, Li, Xiao-Jun, Crumb, William, Wu, Lin, Koltun, Dmitry, Zablocki, Jeff, Yao, Lina, Dhalla, Arvinder K, Rajamani, Sridharan, Shryock, John C
Published in The Journal of pharmacology and experimental therapeutics (01.01.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2013)
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Journal Article
Blocking Late Sodium Current Reduces Hydrogen Peroxide-Induced Arrhythmogenic Activity and Contractile Dysfunction
Song, Yejia, Shryock, John C, Wagner, Stefan, Maier, Lars S, Belardinelli, Luiz
Published in The Journal of pharmacology and experimental therapeutics (01.07.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2006)
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Journal Article
Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes
Viatchenko-Karpinski, Serge, Kornyeyev, Dmytro, El-Bizri, Nesrine, Budas, Grant, Fan, Peidong, Jiang, Zhan, Yang, Jin, Anderson, Mark E., Shryock, John C., Chang, Ching-Pin, Belardinelli, Luiz, Yao, Lina
Published in Journal of molecular and cellular cardiology (01.11.2014)
Published in Journal of molecular and cellular cardiology (01.11.2014)
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Journal Article
Use-dependent block of cardiac late Na(+) current by ranolazine
Rajamani, Sridharan, El-Bizri, Nesrine, Shryock, John C, Makielski, Jonathan C, Belardinelli, Luiz
Published in Heart rhythm (01.11.2009)
Published in Heart rhythm (01.11.2009)
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Journal Article
Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na+ current in the heart
Wu, Lin, Rajamani, Sridharan, Li, Hong, January, Craig T, Shryock, John C, Belardinelli, Luiz
Published in American journal of physiology. Heart and circulatory physiology (01.09.2009)
Published in American journal of physiology. Heart and circulatory physiology (01.09.2009)
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Journal Article
Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes
Ma, Jihua, Luo, Antao, Wu, Lin, Wan, Wei, Zhang, Peihua, Ren, Zhiqiang, Zhang, Shuo, Qian, Chunping, Shryock, John C, Belardinelli, Luiz
Published in American Journal of Physiology: Cell Physiology (15.04.2012)
Published in American Journal of Physiology: Cell Physiology (15.04.2012)
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Journal Article
The Late Na+ Current (INa) Inhibitor Ranolazine Attenuates Effects of Palmitoyl-L-Carnitine to Increase Late INa and Cause Ventricular Diastolic Dysfunction
Wu, Yuzhi, Song, Yejia, Belardinelli, Luiz, Shryock, John C
Published in The Journal of pharmacology and experimental therapeutics (01.08.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2009)
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Journal Article
Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion
Dhalla, Arvinder K, Wang, Wei-Qun, Dow, Joan, Shryock, John C, Belardinelli, Luiz, Bhandari, Anil, Kloner, Robert A
Published in American journal of physiology. Heart and circulatory physiology (01.11.2009)
Published in American journal of physiology. Heart and circulatory physiology (01.11.2009)
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Journal Article
Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine
Wu, Lin, Guo, Donglin, Li, Hong, Hackett, James, Yan, Gan-Xin, Jiao, Zhen, Antzelevitch, Charles, Shryock, John C, Belardinelli, Luiz
Published in Heart rhythm (01.12.2008)
Published in Heart rhythm (01.12.2008)
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Journal Article
Adenosine and Adenosine Receptors in the Cardiovascular System: Biochemistry, Physiology, and Pharmacology
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Journal Article
Conference Proceeding
An Increase in Late Sodium Current Potentiates the Proarrhythmic Activities of Low-Risk QT-Prolonging Drugs in Female Rabbit Hearts
Wu, Lin, Shryock, John C, Song, Yejia, Belardinelli, Luiz
Published in The Journal of pharmacology and experimental therapeutics (01.02.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2006)
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Journal Article
Ranolazine attenuates hypoxia- and hydrogen peroxide-induced increases in sodium channel late openings in ventricular myocytes
Ma, Jihua, Song, Yejia, Shryock, John C, Hu, Liangkun, Wang, Weiping, Yan, Xisheng, Zhang, Peihua, Belardinelli, Luiz
Published in Journal of cardiovascular pharmacology (01.07.2014)
Published in Journal of cardiovascular pharmacology (01.07.2014)
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Journal Article
Antilipolytic Activity of a Novel Partial A1 Adenosine Receptor Agonist Devoid of Cardiovascular Effects: Comparison with Nicotinic Acid
Dhalla, Arvinder K, Santikul, Melissa, Smith, Michelle, Wong, Mei-Yee, Shryock, John C, Belardinelli, Luiz
Published in The Journal of pharmacology and experimental therapeutics (01.04.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2007)
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