Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy
Kahn-Kirby, Amanda H, Amagata, Akiko, Maeder, Celine I, Mei, Janet J, Sideris, Steve, Kosaka, Yuko, Hinman, Andrew, Malone, Stephanie A, Bruegger, Joel J, Wang, Leslie, Kim, Virna, Shrader, William D, Hoff, Kevin G, Latham, Joey C, Ashley, Euan A, Wheeler, Matthew T, Bertini, Enrico, Carrozzo, Rosalba, Martinelli, Diego, Dionisi-Vici, Carlo, Chapman, Kimberly A, Enns, Gregory M, Gahl, William, Wolfe, Lynne, Saneto, Russell P, Johnson, Simon C, Trimmer, Jeffrey K, Klein, Matthew B, Holst, Charles R
Published in PloS one (28.03.2019)
Published in PloS one (28.03.2019)
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EPI-743 reverses the progression of the pediatric mitochondrial disease—Genetically defined Leigh Syndrome
Martinelli, Diego, Catteruccia, Michela, Piemonte, Fiorella, Pastore, Anna, Tozzi, Giulia, Dionisi-Vici, Carlo, Pontrelli, Giuseppe, Corsetti, Tiziana, Livadiotti, Susanna, Kheifets, Viktoria, Hinman, Andrew, Shrader, William D., Thoolen, Martin, Klein, Matthew B., Bertini, Enrico, Miller, Guy
Published in Molecular genetics and metabolism (01.11.2012)
Published in Molecular genetics and metabolism (01.11.2012)
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Journal Article
Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase
Hinman, Andrew, Holst, Charles R, Latham, Joey C, Bruegger, Joel J, Ulas, Gözde, McCusker, Kevin P, Amagata, Akiko, Davis, Dana, Hoff, Kevin G, Kahn-Kirby, Amanda H, Kim, Virna, Kosaka, Yuko, Lee, Edgar, Malone, Stephanie A, Mei, Janet J, Richards, Steve James, Rivera, Veronica, Miller, Guy, Trimmer, Jeffrey K, Shrader, William D
Published in PloS one (15.08.2018)
Published in PloS one (15.08.2018)
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Journal Article
The Structure of the Extracellular Region of Human Hepsin Reveals a Serine Protease Domain and a Novel Scavenger Receptor Cysteine-Rich (SRCR) Domain
Somoza, John R, Ho, Joseph D, Luong, Christine, Ghate, Manjiri, Sprengeler, Paul A, Mortara, Kyle, Shrader, William D, Sperandio, David, Chan, Hedy, McGrath, Mary E, Katz, Bradley A
Published in Structure (London) (01.09.2003)
Published in Structure (London) (01.09.2003)
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Journal Article
Initial experience in the treatment of inherited mitochondrial disease with EPI-743
Enns, Gregory M., Kinsman, Stephen L., Perlman, Susan L., Spicer, Kenneth M., Abdenur, Jose E., Cohen, Bruce H., Amagata, Akiko, Barnes, Adam, Kheifets, Viktoria, Shrader, William D., Thoolen, Martin, Blankenberg, Francis, Miller, Guy
Published in Molecular genetics and metabolism (01.01.2012)
Published in Molecular genetics and metabolism (01.01.2012)
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Journal Article
LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson's disease
Keeney, Matthew T, Rocha, Emily M, Hoffman, Eric K, Farmer, Kyle, Di Maio, Roberto, Weir, Julie, Wagner, Weston G, Hu, Xiaoping, Clark, Courtney L, Castro, Sandra L, Scheirer, Abigail, Fazzari, Marco, De Miranda, Briana R, Pintchovski, Sean A, Shrader, William D, Pagano, Patrick J, Hastings, Teresa G, Greenamyre, J Timothy
Published in Science translational medicine (02.10.2024)
Published in Science translational medicine (02.10.2024)
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Journal Article
Discovery of novel heterocyclic factor VIIa inhibitors
Rai, Roopa, Kolesnikov, Aleksandr, Sprengeler, Paul A., Torkelson, Steven, Ton, Tony, Katz, Bradley A., Yu, Christine, Hendrix, John, Shrader, William D., Stephens, Robin, Cabuslay, Ronnell, Sanford, Ellen, Young, Wendy B.
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
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Journal Article
α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging
Shrader, William D., Amagata, Akiko, Barnes, Adam, Enns, Gregory M., Hinman, Andrew, Jankowski, Orion, Kheifets, Viktoria, Komatsuzaki, Ryo, Lee, Edgar, Mollard, Paul, Murase, Katsuyuki, Sadun, Alfredo A., Thoolen, Martin, Wesson, Kieron, Miller, Guy
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Journal Article
Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model
Young, Wendy B., Mordenti, Joyce, Torkelson, Steven, Shrader, William D., Kolesnikov, Aleksandr, Rai, Roopa, Liu, Liang, Hu, Huiyong, Leahy, Ellen M., Green, Michael J., Sprengeler, Paul A., Katz, Bradley A., Yu, Christine, Janc, James W., Elrod, Kyle C., Marzec, Ulla M., Hanson, Stephen R.
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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Journal Article
Effect of EPI-743 on the Clinical Course of the Mitochondrial Disease Leber Hereditary Optic Neuropathy
Sadun, Alfredo A, Chicani, Carlos Filipe, Ross-Cisneros, Fred N, Barboni, Piero, Thoolen, Martin, Shrader, William D, Kubis, Kenneth, Carelli, Valerio, Miller, Guy
Published in Archives of neurology (Chicago) (01.03.2012)
Published in Archives of neurology (Chicago) (01.03.2012)
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Journal Article
Towards a modern definition of vitamin E—evidence for a quinone hypothesis
Shrader, William D., Amagata, Akiko, Barnes, Adam, Hinman, Andrew, Jankowski, Orion, Lee, Edgar, Kheifets, Viktoria, Komatsuzaki, Ryo, Mollard, Paul, Murase, Katsuyuki, Rioux, Patrice, Wesson, Kieron, Miller, Guy
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Journal Article
Potent 4-amino-5-azaindole factor VIIa inhibitors
Hu, Huiyong, Kolesnikov, Aleksandr, Riggs, Jennifer R., Wesson, Kieron E., Stephens, Robin, Leahy, Ellen M., Shrader, William D., Sprengeler, Paul A., Green, Michael J., Sanford, Ellen, Nguyen, Margaret, Gjerstad, Erik, Cabuslay, Ronnel, Young, Wendy B.
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Journal Article
Factor VIIa inhibitors: A prodrug strategy to improve oral bioavailability
Riggs, Jennifer R., Kolesnikov, Aleksandr, Hendrix, John, Young, Wendy B., Shrader, William D., Vijaykumar, Dange, Stephens, Robin, Liu, Liang, Pan, Lin, Mordenti, Joyce, Green, Michael J., Sukbuntherng, Juthamas
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
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Journal Article
Novel 5-azaindole factor VIIa inhibitors
Riggs, Jennifer R., Hu, Huiyong, Kolesnikov, Aleksandr, Leahy, Ellen M., Wesson, Kieron E., Shrader, William D., Vijaykumar, Dange, Wahl, Troy A., Tong, Zhiwei, Sprengeler, Paul A., Green, Michael J., Yu, Christine, Katz, Brad A., Sanford, Ellen, Nguyen, Margaret, Cabuslay, Ronnel, Young, Wendy B.
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
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Journal Article
Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors
Katz, Bradley A., Elrod, Kyle, Verner, Erik, Mackman, Richard L., Luong, Christine, Shrader, William D., Sendzik, Martin, Spencer, Jeffrey R., Sprengeler, Paul A., Kolesnikov, Aleks, Tai, Vincent W.-F., Hui, Hon C., Guy Breitenbucher, J., Allen, Darin, Janc, James W.
Published in Journal of molecular biology (23.05.2003)
Published in Journal of molecular biology (23.05.2003)
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Journal Article
Optimization of a screening lead for factor VIIa/TF
Young, Wendy B, Kolesnikov, Aleksandr, Rai, Roopa, Sprengeler, Paul A, Leahy, Ellen M, Shrader, William D, Sangalang, Joan, Burgess-Henry, Jana, Spencer, Jeff, Elrod, Kyle, Cregar, Lynne
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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Journal Article
Efforts toward oral bioavailability in factor VIIa inhibitors
Vijaykumar, Dange, Rai, Roopa, Shaghafi, Michael, Ton, Tony, Torkelson, Steve, Leahy, Ellen M., Riggs, Jennifer R., Hu, Huiyong, Sprengeler, Paul A., Shrader, William D., O’Bryan, Colin, Cabuslay, Ronnell, Sanford, Ellen, Gjerstadt, Erik, Liu, Liang, Sukbuntherng, Juthamas, Young, Wendy B.
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
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Journal Article
Factor VIIa inhibitors: Gaining selectivity within the trypsin family
Shrader, William D., Kolesnikov, Aleksandr, Burgess-Henry, Jana, Rai, Roopa, Hendrix, John, Hu, Huiyong, Torkelson, Steve, Ton, Tony, Young, Wendy B., Katz, Bradley A., Yu, Christine, Tang, Jie, Cabuslay, Ronnel, Sanford, Ellen, Janc, James W., Sprengeler, Paul A.
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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Journal Article
Generation of potent coagulation protease inhibitors utilizing zinc-mediated chelation
Young, Wendy B., Sprengeler, Paul, Shrader, William D., Li, Yong, Rai, Roopa, Verner, Erik, Jenkins, Thomas, Fatheree, Paul, Kolesnikov, Aleksandr, Janc, James W., Cregar, Lynne, Elrod, Kyle, Katz, Brad
Published in Bioorganic & medicinal chemistry letters (01.02.2006)
Published in Bioorganic & medicinal chemistry letters (01.02.2006)
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Journal Article
Factor VIIa inhibitors: Improved pharmacokinetic parameters
Kolesnikov, Aleksandr, Rai, Roopa, Young, Wendy B., Mordenti, Joyce, Liu, Liang, Torkelson, Steven, Shrader, William D., Leahy, Ellen M., Hu, Huiyong, Gjerstad, Erik, Janc, James, Katz, Bradley A., Sprengeler, Paul A.
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
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Journal Article