Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans
Watanabe, Takao, Kusuhara, Hiroyuki, Maeda, Kazuya, Shitara, Yoshihisa, Sugiyama, Yuichi
Published in The Journal of pharmacology and experimental therapeutics (01.02.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2009)
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Journal Article
Transporters as a determinant of drug clearance and tissue distribution
Shitara, Yoshihisa, Horie, Toshiharu, Sugiyama, Yuichi
Published in European journal of pharmaceutical sciences (01.04.2006)
Published in European journal of pharmaceutical sciences (01.04.2006)
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Journal Article
Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs
SHITARA, Yoshihisa, SATO, Hitoshi, SUGIYAMA, Yuichi
Published in Annual review of pharmacology and toxicology (01.01.2005)
Published in Annual review of pharmacology and toxicology (01.01.2005)
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Journal Article
Long-Lasting Inhibitory Effects of Saquinavir and Ritonavir on OATP1B1-Mediated Uptake
Shitara, Yoshihisa, Takeuchi, Kumiko, Horie, Toshiharu
Published in Journal of pharmaceutical sciences (01.09.2013)
Published in Journal of pharmaceutical sciences (01.09.2013)
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Journal Article
Disruption of ZO-1/claudin-4 interaction in relation to inflammatory responses in methotrexate-induced intestinal mucositis
Hamada, Kazuma, Kakigawa, Naoko, Sekine, Shuichi, Shitara, Yoshihisa, Horie, Toshiharu
Published in Cancer chemotherapy and pharmacology (01.10.2013)
Published in Cancer chemotherapy and pharmacology (01.10.2013)
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Journal Article
Gemfibrozil and Its Glucuronide Inhibit the Organic Anion Transporting Polypeptide 2 (OATP2/OATP1B1:SLC21A6)-Mediated Hepatic Uptake and CYP2C8-Mediated Metabolism of Cerivastatin: Analysis of the Mechanism of the Clinically Relevant Drug-Drug Interaction between Cerivastatin and Gemfibrozil
Shitara, Yoshihisa, Hirano, Masaru, Sato, Hitoshi, Sugiyama, Yuichi
Published in The Journal of pharmacology and experimental therapeutics (01.10.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2004)
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Journal Article
The Quantitative Prediction of CYP-mediated Drug Interaction by Physiologically Based Pharmacokinetic Modeling
Kato, Motohiro, Shitara, Yoshihisa, Sato, Hitoshi, Yoshisue, Kunihiro, Hirano, Masaru, Ikeda, Toshihiko, Sugiyama, Yuichi
Published in Pharmaceutical research (01.08.2008)
Published in Pharmaceutical research (01.08.2008)
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Journal Article
Long-lasting Inhibitory Effects of Cyclosporin A, but Not Tacrolimus, on OATP1B1- and OATP1B3-mediated Uptake
Shitara, Yoshihisa, Takeuchi, Kumiko, Nagamatsu, Yoshiko, Wada, Satomi, Sugiyama, Yuichi, Horie, Toshiharu
Published in Drug metabolism and pharmacokinetics (2012)
Published in Drug metabolism and pharmacokinetics (2012)
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Journal Article
Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria
Shitara, Yoshihisa, Nakamichi, Noritaka, Norioka, Misaki, Shima, Hiroyo, Kato, Yukio, Horie, Toshiharu
Published in Toxicological sciences (01.03.2013)
Published in Toxicological sciences (01.03.2013)
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Journal Article
Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A
Shitara, Yoshihisa, Itoh, Tomoo, Sato, Hitoshi, Li, Albert P, Sugiyama, Yuichi
Published in The Journal of pharmacology and experimental therapeutics (01.02.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2003)
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Journal Article
DRUG-DRUG INTERACTION BETWEEN PITAVASTATIN AND VARIOUS DRUGS VIA OATP1B1
HIRANO, Masaru, MAEDA, Kazuya, SHITARA, Yoshihisa, SUGIYAMA, Yuichi
Published in Drug metabolism and disposition (01.07.2006)
Published in Drug metabolism and disposition (01.07.2006)
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Journal Article
Model‐based simulation to support the approval of isatuximab alone or with dexamethasone for the treatment of relapsed/refractory multiple myeloma in Japanese patients
Thai, Hoai‐Thu, Koiwai, Kimiko, Shitara, Yoshihisa, Kazama, Hirotaka, Fau, Jean‐Baptiste, Semiond, Dorothée, Veyrat‐Follet, Christine
Published in CPT: pharmacometrics and systems pharmacology (01.12.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.12.2023)
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Journal Article
Increase in the systemic exposure of primary metabolites of Midazolam in rat arising from CYP inhibition or hepatic dysfunction
Hasegawa, Tsubasa, Nakanishi, Satomi, Minami, Keiko, Higashino, Haruki, Kataoka, Makoto, Shitara, Yoshihisa, Yamashita, Shinji
Published in Drug metabolism and pharmacokinetics (01.02.2017)
Published in Drug metabolism and pharmacokinetics (01.02.2017)
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Journal Article